https://healthtolongevity.com Daily synthesized updates on health, longevity, nutrition, diet studies, and lifestyle research. https://healthtolongevity.com/article/28798/temperature-regulated-sleep-surface-adds-33-minutes-of-sleep-in-most-sleep-depri https://healthtolongevity.com/article/28798/temperature-regulated-sleep-surface-adds-33-minutes-of-sleep-in-most-sleep-depri Fri, 02 Oct 2026 05:00:03 +0000 Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep surface (Orion Sleep System), cohort-wide gains were modest: total sleep time rose just 7.3 minutes and heart rate variability (HRV) increased 3.25 ms. But… https://healthtolongevity.com/article/28789/dash-diet-adherence-among-hypertensive-us-adults-dropped-16-by-2018 https://healthtolongevity.com/article/28789/dash-diet-adherence-among-hypertensive-us-adults-dropped-16-by-2018 Fri, 02 Oct 2026 05:00:03 +0000 Among 14,163 US adults with self-reported hypertension drawn from NHANES cycles 2003–2018, adherence to the DASH diet declined significantly — from 22.1% in 2003–2010 to 18.6% in 2011–2018 (adjusted OR 0.78; 95% CI 0.67–0.91). Mean DASH scores also fell (2.98 to 2.85). Sodium… https://healthtolongevity.com/article/28788/lab4-probiotic-cuts-gp-visits-by-52-in-healthcare-workersbut-trial-too-small https://healthtolongevity.com/article/28788/lab4-probiotic-cuts-gp-visits-by-52-in-healthcare-workersbut-trial-too-small Fri, 02 Oct 2026 05:00:03 +0000 In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently favourable but statistically non-significant reductions across all illness-related endpoints compared with placebo. URTI occurrence risk was 40% lower (RR 0.60… https://healthtolongevity.com/article/28787/diet-as-medicine-app-cuts-blood-pressure-55-mmhg-after-correcting-statistical-bi https://healthtolongevity.com/article/28787/diet-as-medicine-app-cuts-blood-pressure-55-mmhg-after-correcting-statistical-bi Fri, 02 Oct 2026 05:00:03 +0000 A retrospective cohort study of 329 US adults with obesity enrolled in a commercial digital food-as-medicine program found meaningful but statistically inflated blood pressure reductions when using raw pre/post comparisons. Among Stage-2 hypertensive members (≥135/85 mmHg)… https://healthtolongevity.com/article/28785/four-inflammatory-markers-explain-57-of-black-white-heart-failure-gap https://healthtolongevity.com/article/28785/four-inflammatory-markers-explain-57-of-black-white-heart-failure-gap Fri, 02 Oct 2026 05:00:03 +0000 In a 16-year prospective follow-up of 6,785 multi-ethnic adults (MESA cohort, 2000–2002), four baseline biomarkers — IL-6, D-dimer, CRP, and fibrinogen — each independently predicted incident heart failure (485 events). Hazard ratios per 1-SD increment ranged from 1.13… https://healthtolongevity.com/article/28782/masld-high-lpa-doubles-cardiovascular-risk-in-multi-ethnic-cohort https://healthtolongevity.com/article/28782/masld-high-lpa-doubles-cardiovascular-risk-in-multi-ethnic-cohort Fri, 02 Oct 2026 03:00:04 +0000 In a secondary analysis of the Multi-Ethnic Study of Atherosclerosis (MESA), adults with metabolic dysfunction-associated steatotic liver disease (MASLD) — defined by CT-measured liver-to-spleen attenuation ratios — had paradoxically lower median Lp(a) levels than those without… https://healthtolongevity.com/article/28780/in-hospital-statins-cut-mortality-49-in-adults-over-75 https://healthtolongevity.com/article/28780/in-hospital-statins-cut-mortality-49-in-adults-over-75 Fri, 02 Oct 2026 03:00:04 +0000 Among 545 patients aged 75 or older admitted to an acute geriatric ward, receiving statin therapy on day 2 of hospitalisation was associated with a 49% reduction in adjusted odds of in-hospital all-cause mortality (OR 0.51, 95% CI 0.3–1.0) and a 6.3% absolute risk reduction… https://healthtolongevity.com/article/28777/atorvastatin-40mg-cuts-cv-events-30-in-over-70s-but-misses-disability-free-survi https://healthtolongevity.com/article/28777/atorvastatin-40mg-cuts-cv-events-30-in-over-70s-but-misses-disability-free-survi Fri, 02 Oct 2026 03:00:04 +0000 In the STAREE trial — a double-blind, randomized, placebo-controlled study of 9,971 community-dwelling Australians aged 70+ with no prior cardiovascular disease, diabetes, or dementia — atorvastatin 40 mg daily produced a striking 30% relative reduction in major cardiovascular… https://healthtolongevity.com/article/28776/unstructured-daily-movement-cuts-depression-and-blood-pressure-in-8551-adults https://healthtolongevity.com/article/28776/unstructured-daily-movement-cuts-depression-and-blood-pressure-in-8551-adults Fri, 02 Oct 2026 03:00:04 +0000 Across 38 randomized controlled trials enrolling 8,551 adults, interventions that wove physical activity into daily routines — lifestyle-integrated functional exercise, zero-time exercise, walking prompts, and standing breaks — produced statistically significant gains in… https://healthtolongevity.com/article/28775/weak-grip-underweight-quintuples-premature-death-risk-in-200k-adults https://healthtolongevity.com/article/28775/weak-grip-underweight-quintuples-premature-death-risk-in-200k-adults Fri, 02 Oct 2026 03:00:04 +0000 In a prospective analysis of 200,405 UK Biobank participants aged 60 and older (median follow-up ~14.5 years), underweight older adults with abnormal grip strength faced a nearly fivefold increase in premature mortality risk (HR = 4.96, 95% CI: 3.07–8.01) compared to… https://healthtolongevity.com/article/28773/dietitian-led-nutrition-beats-standard-advice-for-cirrhosis-sarcopenia-rct https://healthtolongevity.com/article/28773/dietitian-led-nutrition-beats-standard-advice-for-cirrhosis-sarcopenia-rct Fri, 02 Oct 2026 03:00:04 +0000 In a 180-patient randomised controlled trial of decompensated cirrhosis with sarcopenia, six months of dietitian-supervised intensive nutritional therapy (targeting 35–40 kcal/kg/day, 1.2–1.5 g protein/kg/day) produced a skeletal muscle index gain 2.50 cm²/m² greater than… https://healthtolongevity.com/article/28771/vitamin-d-supplements-show-little-bone-benefit-in-non-white-adults-across-8000-p https://healthtolongevity.com/article/28771/vitamin-d-supplements-show-little-bone-benefit-in-non-white-adults-across-8000-p Fri, 02 Oct 2026 03:00:04 +0000 A systematic review and meta-analysis of 12 randomised controlled trials encompassing 8,023 adults from Black African, South Asian, South Korean, and Chinese populations found that vitamin D supplementation — ranging from 400 to 6,400 IU/day over 3 months to 5.3 years… https://healthtolongevity.com/article/28770/oral-semaglutide-cuts-body-weight-105-in-28-weeks-shrinks-liver-fat https://healthtolongevity.com/article/28770/oral-semaglutide-cuts-body-weight-105-in-28-weeks-shrinks-liver-fat Fri, 02 Oct 2026 03:00:04 +0000 In a 28-week randomized controlled trial of 116 non-diabetic adults with obesity or overweight plus comorbidities, oral semaglutide (titrated from 3 mg to 14 mg/day) combined with lifestyle counselling produced a mean weight reduction of 10.47% versus 2.4% in the lifestyle-only… https://healthtolongevity.com/article/28766/resistance-training-after-weight-loss-prevents-t2d-risk-rebound-at-1-year https://healthtolongevity.com/article/28766/resistance-training-after-weight-loss-prevents-t2d-risk-rebound-at-1-year Fri, 02 Oct 2026 03:00:04 +0000 Among 221 sedentary women with overweight (mean BMI 28.3), an 800 kcal/day diet drove BMI to 23.9, slashing predicted 10-year MACE and type 2 diabetes risk across all three arms — Diet+Aerobic, Diet+Resistance, and Diet-only. By the 1-year follow-up, BMI had rebounded to 25.8… https://healthtolongevity.com/article/28765/higher-lifelong-activity-cuts-dementia-risk-25-across-four-nations https://healthtolongevity.com/article/28765/higher-lifelong-activity-cuts-dementia-risk-25-across-four-nations Fri, 02 Oct 2026 03:00:04 +0000 Across four major aging cohorts — HRS (USA), ELSA (UK), SHARE (Europe), and MHAS (Mexico) — adults who maintained higher physical activity trajectories over time faced a 25% lower risk of transitioning from normal cognition to mild cognitive impairment (pooled HR = 0.75, 95% CI… https://healthtolongevity.com/article/28763/18-month-exercise-nutrition-program-slows-cognitive-decline-in-targeted-older-ad https://healthtolongevity.com/article/28763/18-month-exercise-nutrition-program-slows-cognitive-decline-in-targeted-older-ad Thu, 01 Oct 2026 15:00:04 +0000 An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant cognitive preservation — but only in a specific subgroup. Among 188 Japanese older adults in the J-MINT PRIME Kanagawa trial, a CART-identified 'Target Group'… https://healthtolongevity.com/article/28761/ultra-processed-foods-raise-stroke-death-risk-21-per-10-point-increase-in-mi-sur https://healthtolongevity.com/article/28761/ultra-processed-foods-raise-stroke-death-risk-21-per-10-point-increase-in-mi-sur Thu, 01 Oct 2026 15:00:04 +0000 In 4,365 post-myocardial infarction patients followed for a median 14 years in the Dutch Alpha Omega Cohort, each 10-percentage-point increase in ultra-processed food (UPF) intake — measured as grams per day via a 203-item food-frequency questionnaire — was associated with a… https://healthtolongevity.com/article/28757/151-genes-linked-to-muscle-strength-preservation-during-2-year-calorie-restricti https://healthtolongevity.com/article/28757/151-genes-linked-to-muscle-strength-preservation-during-2-year-calorie-restricti Thu, 01 Oct 2026 15:00:04 +0000 A secondary transcriptomic analysis of the landmark CALERIE randomized controlled trial — a 2-year caloric restriction study in healthy, non-obese adults — identified 151 genes significantly associated with maintaining knee extensor strength independent of overall body mass… https://healthtolongevity.com/article/28755/bariatric-surgery-neurological-risk-1416-incidence-thiamine-deficiency-dominates https://healthtolongevity.com/article/28755/bariatric-surgery-neurological-risk-1416-incidence-thiamine-deficiency-dominates Thu, 01 Oct 2026 15:00:04 +0000 Across 12 studies encompassing more than 5,000 bariatric surgery patients, neurological complication rates ranged from 1.4% to 16%, with peripheral neuropathy the most common manifestation. Thiamine (vitamin B1) deficiency was the primary driver, particularly of serious central… https://healthtolongevity.com/article/28754/social-isolation-after-stroke-raises-cvd-death-risk-57-loneliness-doubles-dement https://healthtolongevity.com/article/28754/social-isolation-after-stroke-raises-cvd-death-risk-57-loneliness-doubles-dement Thu, 01 Oct 2026 15:00:04 +0000 Among 7,267 stroke survivors in the UK Biobank followed for a median 10.2 years, social isolation independently raised all-cause mortality risk by 41% (HR 1.41), CVD mortality by 57% (HR 1.57), and depression by 35% (HR 1.35). Loneliness carried even steeper penalties for… https://healthtolongevity.com/article/28753/12-week-rthiit-shows-minimal-transcriptomic-gains-polyphenols-add-nothing https://healthtolongevity.com/article/28753/12-week-rthiit-shows-minimal-transcriptomic-gains-polyphenols-add-nothing Thu, 01 Oct 2026 15:00:04 +0000 A 12-week supervised concurrent resistance training plus HIIT programme in 38 adults aged 55–70 years produced surprisingly modest skeletal muscle transcriptional changes. RNA-sequencing of vastus lateralis biopsies revealed only seven transcripts exceeding both FDR… https://healthtolongevity.com/article/28752/training-at-peak-vs-trough-time-of-day-makes-no-difference-for-older-adults https://healthtolongevity.com/article/28752/training-at-peak-vs-trough-time-of-day-makes-no-difference-for-older-adults Thu, 01 Oct 2026 15:00:04 +0000 A 12-week randomized controlled trial in 93 adults (mean age 67) found that matching resistance training to an individual's peak versus trough performance time produced virtually no difference in muscle strength or mass. Effect sizes for isometric midthigh pull strength (0.06… https://healthtolongevity.com/article/28751/higher-omega-3-blood-levels-linked-to-less-amyloid-in-apoe4-carriers https://healthtolongevity.com/article/28751/higher-omega-3-blood-levels-linked-to-less-amyloid-in-apoe4-carriers Thu, 01 Oct 2026 15:00:04 +0000 Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2% APOE4 carriers), higher serum DHA+EPA levels correlated with greater gray matter volume in the left precuneus/postcentral gyrus and lower amyloid-beta (Aβ) burden… https://healthtolongevity.com/article/28748/healthy-sleep-cuts-stroke-risk-14-via-lipid-and-inflammation-pathways https://healthtolongevity.com/article/28748/healthy-sleep-cuts-stroke-risk-14-via-lipid-and-inflammation-pathways Thu, 01 Oct 2026 15:00:04 +0000 In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component healthy sleep score (covering chronotype, duration, insomnia, snoring, daytime dozing, and ease of waking) was associated with a 3% lower stroke hazard. More… https://healthtolongevity.com/article/28747/dietetic-counseling-cuts-systolic-bp-57-mmhg-wearables-add-modest-pulse-pressure https://healthtolongevity.com/article/28747/dietetic-counseling-cuts-systolic-bp-57-mmhg-wearables-add-modest-pulse-pressure Thu, 01 Oct 2026 15:00:04 +0000 In a 954-person, three-arm RCT of adults aged ≥55 with metabolic syndrome risk factors, all intervention groups achieved meaningful cardiometabolic improvements over 12 weeks. Systolic blood pressure fell 4.84–7.15 mmHg across groups, and waist circumference shrank 4.69–6.29… https://healthtolongevity.com/article/28745/weekly-dual-gipglucagon-agonist-cuts-weight-significantly-in-obese-diabetics https://healthtolongevity.com/article/28745/weekly-dual-gipglucagon-agonist-cuts-weight-significantly-in-obese-diabetics Thu, 01 Oct 2026 12:35:52 +0000 The convergence of obesity and type 2 diabetes represents one of the most consequential metabolic challenges in modern medicine, and the race to find agents that address both simultaneously has intensified dramatically. A new entrant — survodutide, a dual glucagon receptor and… https://healthtolongevity.com/article/28732/semaglutide-shows-measurable-kidney-protective-mechanisms-in-diabetic-patients https://healthtolongevity.com/article/28732/semaglutide-shows-measurable-kidney-protective-mechanisms-in-diabetic-patients Thu, 01 Oct 2026 12:35:20 +0000 Chronic kidney disease is the leading cause of end-stage renal failure in adults with type 2 diabetes, and slowing its progression remains one of the most consequential therapeutic challenges in metabolic medicine. Evidence that a widely used GLP-1 receptor agonist can… https://healthtolongevity.com/article/28729/repeated-partner-inflicted-head-injuries-age-womens-brains-by-up-to-28-years https://healthtolongevity.com/article/28729/repeated-partner-inflicted-head-injuries-age-womens-brains-by-up-to-28-years Thu, 01 Oct 2026 05:00:04 +0000 Among 207 women with lifetime exposure to physical intimate partner violence, those reporting ten or more partner-inflicted brain injuries performed worse than nearly 80% of the general population on overall cognitive function (Cohen's d = 0.82). Translated into cognitive age… https://healthtolongevity.com/article/28718/frequent-high-no2-days-accelerate-14-year-cognitive-decline-in-older-adults https://healthtolongevity.com/article/28718/frequent-high-no2-days-accelerate-14-year-cognitive-decline-in-older-adults Thu, 01 Oct 2026 05:00:04 +0000 Among 12,235 English adults aged 50 and older followed for up to 14 years in the English Longitudinal Study of Ageing, a higher annual count of days exceeding WHO nitrogen dioxide guidelines was independently associated with faster cognitive decline — even after controlling for… https://healthtolongevity.com/article/28715/hdl-cholesterol-shows-j-and-u-shaped-mortality-curves-in-150000-adults https://healthtolongevity.com/article/28715/hdl-cholesterol-shows-j-and-u-shaped-mortality-curves-in-150000-adults Thu, 01 Oct 2026 05:00:04 +0000 In 47,123 Mexican men and 97,589 women followed prospectively, HDL cholesterol showed non-linear associations with mortality that diverge by sex. Men displayed a J-shaped curve — very high HDL (>95th percentile) raised the hazard ratio for non-CVD deaths to 1.27, rising to 1.82… https://healthtolongevity.com/article/28713/sleep-hypoxic-burden-outperforms-ahi-for-heart-failure-prognosis-over-37-years https://healthtolongevity.com/article/28713/sleep-hypoxic-burden-outperforms-ahi-for-heart-failure-prognosis-over-37-years Thu, 01 Oct 2026 05:00:04 +0000 Among 178 heart failure patients not receiving airway pressure therapy — followed for a median 3.7 years after acute HF hospitalization — sleep apnea-specific hypoxic burden (SASHB) independently predicted the composite endpoint of cardiovascular death or HF rehospitalization… https://healthtolongevity.com/article/28711/meeting-bp-ldl-and-a1c-targets-still-leaves-24-cv-risk-gap-by-social-context https://healthtolongevity.com/article/28711/meeting-bp-ldl-and-a1c-targets-still-leaves-24-cv-risk-gap-by-social-context Thu, 01 Oct 2026 05:00:04 +0000 Among adults in the All of Us cohort who already met standard cardiovascular prevention targets — systolic BP below 140 mmHg, LDL below 100 mg/dL, or A1c below 8% — a composite social context score (combining household income, education, food security, physical activity, and… https://healthtolongevity.com/article/28707/heart-healthy-diet-cuts-fatty-liver-odds-by-84-in-iranian-adults https://healthtolongevity.com/article/28707/heart-healthy-diet-cuts-fatty-liver-odds-by-84-in-iranian-adults Thu, 01 Oct 2026 03:00:05 +0000 In a case-control study of 675 Iranian adults (225 NAFLD cases, 450 controls), those scoring in the highest tertile of the Cardiovascular Health Diet Index (CHDI) had 84% lower odds of non-alcoholic fatty liver disease compared to the lowest tertile (OR = 0.16; 95% CI… https://healthtolongevity.com/article/28706/personalized-dietary-plans-beat-usual-care-for-masld-weight-loss-by-67-kg https://healthtolongevity.com/article/28706/personalized-dietary-plans-beat-usual-care-for-masld-weight-loss-by-67-kg Thu, 01 Oct 2026 03:00:05 +0000 Across 14 randomized controlled trials enrolling 1,805 adults with metabolic dysfunction-associated steatotic liver disease (MASLD), two lifestyle approaches outperformed usual care on key metabolic markers. Biomarker-guided personalized dietary management (BPDM) produced the… https://healthtolongevity.com/article/28704/lean-masld-carries-similar-long-term-mortality-risk-as-obese-masld https://healthtolongevity.com/article/28704/lean-masld-carries-similar-long-term-mortality-risk-as-obese-masld Thu, 01 Oct 2026 03:00:05 +0000 In a multinational retrospective study of 18,326 biopsy-confirmed MASLD patients across 41 countries, lean individuals (6.7% by BMI) had meaningfully lower rates of type 2 diabetes (38.2% vs 48.3%), advanced fibrosis (29.3% vs 37.2%), and histologic activity scores compared… https://healthtolongevity.com/article/28694/smoking-after-heart-attack-doubles-mortality-risk-vs-quitters https://healthtolongevity.com/article/28694/smoking-after-heart-attack-doubles-mortality-risk-vs-quitters Wed, 30 Sep 2026 15:00:04 +0000 Among 65,990 Spanish adults tracked across three national health surveys (2011–2017) and linked to mortality data through December 2023, 13.3% of those with prior myocardial infarction or stroke continued smoking. Current smokers with prior MI faced a relative risk of all-cause… https://healthtolongevity.com/article/28601/triple-hormone-agonist-retatrutide-drives-substantial-weight-loss-in-phase-iii-t https://healthtolongevity.com/article/28601/triple-hormone-agonist-retatrutide-drives-substantial-weight-loss-in-phase-iii-t Wed, 30 Sep 2026 12:35:24 +0000 Obesity pharmacotherapy is entering a new era, and the latest data suggest the ceiling on drug-induced weight loss may be higher than previously assumed. A Phase III randomized controlled trial of retatrutide — a single molecule targeting GIP, GLP-1, and glucagon receptors… https://healthtolongevity.com/article/28598/insomnia-at-50-predicts-cognitive-decline-same-symptom-reverses-after-75 https://healthtolongevity.com/article/28598/insomnia-at-50-predicts-cognitive-decline-same-symptom-reverses-after-75 Wed, 30 Sep 2026 05:00:03 +0000 Across 16,884 adults from three longitudinal cohorts (ELSA, Whitehall II, and Rush MAP), difficulty falling asleep at least once per week in midlife was associated with meaningfully faster 5-year cognitive decline — a 0.12 SD reduction in recall at age 50 — yet this association… https://healthtolongevity.com/article/28596/cgm-detected-glucose-spikes-raise-liver-scarring-risk-2859-in-non-diabetics https://healthtolongevity.com/article/28596/cgm-detected-glucose-spikes-raise-liver-scarring-risk-2859-in-non-diabetics Wed, 30 Sep 2026 05:00:03 +0000 In 1,071 adults from the Framingham Heart Study Third Generation cohort (mean age 60.2, BMI 28.2, 56% normoglycemic), higher postprandial glucose at 2 hours after a mixed meal and CGM-derived glycemic burden metrics — particularly time above 140 mg/dL — were associated with… https://healthtolongevity.com/article/28591/six-lifestyle-clusters-predict-dementia-risk-worst-combo-raises-hazard-24 https://healthtolongevity.com/article/28591/six-lifestyle-clusters-predict-dementia-risk-worst-combo-raises-hazard-24 Wed, 30 Sep 2026 05:00:03 +0000 Among 151,832 UK Biobank participants aged 60–69, six distinct clusters of co-occurring modifiable risk factors were identified using latent class analysis, all associated with elevated dementia incidence over a median 13-year follow-up during which 5,304 cases developed. The… https://healthtolongevity.com/article/28590/daily-air-pollution-spikes-cut-next-day-steps-by-483-in-adults-over-50 https://healthtolongevity.com/article/28590/daily-air-pollution-spikes-cut-next-day-steps-by-483-in-adults-over-50 Wed, 30 Sep 2026 05:00:03 +0000 In a micro-longitudinal study of 67 UK adults aged 50–85, days with higher-than-usual personal PM2.5 exposure — just 2.6 µg/m³ above an individual's own average — were followed by 8 fewer minutes of light physical activity and 483 fewer steps the next day. Higher PM10… https://healthtolongevity.com/article/28577/erythritol-and-xylitol-show-no-platelet-activating-effect-in-crossover-trial https://healthtolongevity.com/article/28577/erythritol-and-xylitol-show-no-platelet-activating-effect-in-crossover-trial Wed, 30 Sep 2026 05:00:03 +0000 A randomized, single-blind crossover trial in 14 healthy adults tested whether acute oral doses of erythritol (50 g) or xylitol (33.5 g) elevate platelet reactivity compared with water. Despite large rises in circulating sweetener concentrations, neither compound increased ex… https://healthtolongevity.com/article/28567/sglt2-inhibitors-show-no-clear-anti-inflammatory-effect-across-47-trials https://healthtolongevity.com/article/28567/sglt2-inhibitors-show-no-clear-anti-inflammatory-effect-across-47-trials Tue, 29 Sep 2026 15:00:04 +0000 Pooling 47 randomized controlled trials, SGLT2 inhibitor therapy produced no statistically significant reductions in C-reactive protein/hsCRP (MD −1.13 mg/L; 95% CI −2.31 to 0.05) or IL-6 (MD −1.53 pg/mL; 95% CI −3.69 to 0.64). TNF-α showed a modest standardized mean difference… https://healthtolongevity.com/article/28564/cbt-enhanced-liver-program-cuts-cardiovascular-events-64-in-fatty-liver-disease https://healthtolongevity.com/article/28564/cbt-enhanced-liver-program-cuts-cardiovascular-events-64-in-fatty-liver-disease Tue, 29 Sep 2026 15:00:04 +0000 A randomized controlled trial of 286 adults with metabolic dysfunction-associated steatotic liver disease (MASLD) tested a three-arm intervention over 18 months. Patients receiving the full "Co-Co-Nut" protocol — combining hepatologist oversight, individualized nutrition, and… https://healthtolongevity.com/article/28562/endogenous-oestradiol-levels-dont-predict-heart-risk-or-death-in-women-70 https://healthtolongevity.com/article/28562/endogenous-oestradiol-levels-dont-predict-heart-risk-or-death-in-women-70 Tue, 29 Sep 2026 15:00:04 +0000 In 5,535 women aged 70 or older enrolled in the Sex Hormones in Older Women (SHOW) Study — a sub-study of the ASPREE trial — endogenous oestradiol levels measured via the gold-standard liquid chromatography-tandem mass spectrometry showed no independent association with major… https://healthtolongevity.com/article/28561/gut-butyrate-producers-determine-whether-protein-aids-post-stroke-recovery https://healthtolongevity.com/article/28561/gut-butyrate-producers-determine-whether-protein-aids-post-stroke-recovery Tue, 29 Sep 2026 15:00:04 +0000 In 152 older stroke patients (mean age 78.4 years) undergoing inpatient rehabilitation, the benefit of dietary protein density on motor ADL recovery — measured by Functional Independence Measure motor effectiveness — depended significantly on the relative abundance of… https://healthtolongevity.com/article/28555/oral-glp-1-pill-cuts-hba1c-145-in-drug-naive-type-2-diabetes https://healthtolongevity.com/article/28555/oral-glp-1-pill-cuts-hba1c-145-in-drug-naive-type-2-diabetes Tue, 29 Sep 2026 12:35:26 +0000 Injectable GLP-1 receptor agonists have transformed metabolic medicine, but needle aversion and cold-chain logistics keep many patients from accessing them. A fully oral, small-molecule alternative that matches meaningful glycaemic efficacy without requiring peptide formulation… https://healthtolongevity.com/article/28551/night-shift-work-raises-cvd-risk-7-per-5-years-morning-types-hit-hardest https://healthtolongevity.com/article/28551/night-shift-work-raises-cvd-risk-7-per-5-years-morning-types-hit-hardest Tue, 29 Sep 2026 05:00:03 +0000 Among 69,458 female nurses followed from 2009 to 2021 in the Nurses' Health Study II, each additional 5 years of rotating night shift work was associated with a 7% higher risk of incident cardiovascular disease (myocardial infarction or stroke; HR 1.07, 95% CI 1.01–1.14) and a… https://healthtolongevity.com/article/28549/marijuana-cuts-hrv-by-047ms-and-fragments-sleep-across-17000-wearable-users https://healthtolongevity.com/article/28549/marijuana-cuts-hrv-by-047ms-and-fragments-sleep-across-17000-wearable-users Tue, 29 Sep 2026 05:00:03 +0000 Across 16,965 wearable-device users contributing over 5.2 million person-days of data, nightly marijuana use was associated with measurably altered cardiovascular and sleep physiology. Within individuals, use nights showed lower resting heart rate (−0.12 bpm) and reduced heart… https://healthtolongevity.com/article/28543/social-isolation-raises-death-risk-34-transport-mode-modifies-the-harm https://healthtolongevity.com/article/28543/social-isolation-raises-death-risk-34-transport-mode-modifies-the-harm Tue, 29 Sep 2026 05:00:03 +0000 In a UK Biobank cohort of 490,114 adults aged 40–69, followed from 2006 to 2022, social isolation was associated with a 34% higher hazard of all-cause mortality (HR 1.34, 95% CI 1.31–1.38) and a 49% higher hazard of cardiovascular mortality (HR 1.49, CI 1.41–1.57). Crucially…