Studies
DAPK1 Kinase Emerges as Multi-Pathway Target in Alzheimer's Pathogenesis
Most Alzheimer's disease therapies have targeted single pathological hallmarks — amyloid plaques or tau tangles — yet…
Longevity
Adiponectin Links Physical Activity to Delayed Ovarian Aging in Humans and Mice
For women thinking about reproductive longevity and menopause timing, the question of whether lifestyle choices can…
Studies
CRISPR and Biomaterials Converge to Build Immune-Evasive Islet Grafts
For the roughly two million people living with type 1 diabetes globally, the immune system is both cause and obstacle…
Studies
Multinational Validated Model Predicts Severe Asthma Exacerbation Risk Individually
Predicting which severe asthma patient will land in the emergency room within the next year has long been a clinical…
PREPRINTSupplements
NMNH-Ca Raises Whole-Blood NAD+ 39.9 µM at 500mg Over 90 Days
A 90-day randomized, double-blind, placebo-controlled phase I trial in 80 healthy adults aged 40–65 tested oral…
Studies
GLP-1 Drugs Cut Sleep Apnea Severity, But Cardiovascular Proof Remains Elusive
Incretin-based therapies — particularly liraglutide and tirzepatide — demonstrate meaningful reductions in…
Longevity
Rationale Paper Highlights Gq/11 Bias in MC4R Signaling for Future Obesity Drug Design
High-resolution cryo-electron microscopy of the setmelanotide-MC4R-Gq complex reveals that melanocortin-4 receptor…
Longevity
Circumventricular Organs Identified as Key Gateway for GLP-1 Weight-Loss Drug Action
GLP-1 receptor agonists — now the dominant pharmacological approach to obesity — achieve sustained weight loss…
Studies
Semaglutide Tops 4 GLP-1 Drugs Linked to Reversible Gastroparesis in 13 Cases
Across 12 case reports encompassing 13 patients, GLP-1 receptor agonists — predominantly semaglutide, followed by…
Studies
Computational Electrode Optimization Boosts Glioblastoma TTFields Intensity by Up to 34%
For patients with glioblastoma — a brain cancer with a median survival under 18 months even with standard care…
Studies
Regional Chemotherapy Gaps in Sweden Linked to Breast Cancer Survival Disparities
Geographic disparities in cancer treatment are often assumed to reflect patient preference or tumor biology — but when…
Studies
Global Mental Disorder Burden Rose Steadily Across All Regions 1990–2023
Mental illness is not a crisis confined to high-income countries or recent decades — it is a sustained, expanding…
Studies
Klebsiella Liver Abscess Resists Drainage as Antibiotic Tolerance Emerges
Liver abscesses caused by Klebsiella pneumoniae represent one of the more dangerous and understudied infectious…
Studies
Atomic Map of Heart Muscle's Thick Filament Pinpoints Cardiomyopathy Disease Sites
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, affecting roughly 1 in 500 people, yet…
Studies
Rising Maternal Heart Failure Risk Demands Dedicated Cardio-Obstetric Subspecialty Care
Heart failure during and after pregnancy has quietly become one of the most complex frontiers in women's…
Studies
Dual-Role Fungus Bridges Insect Pathogen and Plant Symbiont Worlds
The boundary between beneficial and lethal in the microbial world turns out to be far more porous than classical…
Longevity
GrimAge Epigenetic Clock Flags Cardiometabolic Risk in Men Across Cohorts
For men managing cardiovascular or metabolic conditions, a biological clock may already be ticking faster than their…
Studies
Breastfeeding During Vaccination Cuts Infant Distress by Largest Margin in Meta-Analysis
For parents navigating the repeated vaccination schedule of the first year of life, the question of how to minimize an…
Studies
Minimal Cell Size Limits Reveal Fundamental Constraints on Biological Life
Understanding the physical lower bounds of cellular life has implications far beyond pure biology — it touches on how…
Studies
Rb Protein Paradoxically Fuels Estrogen Signaling While Suppressing Tumors
For decades, the assumption that activating the retinoblastoma protein is unambiguously beneficial in hormone…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.