PREPRINTNutrition
8 Proteins Map Healthy Plant-Based Diets to Lower Cancer and CVD Risk
Analyzing 7,285 circulating protein aptamers in 4,372 EPIC cohort participants, researchers identified specific…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
Single-Subject DELTA Protocol Integrates TRE, Mediterranean Diet, and AI Biomarkers for Healthspan
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
Studies
Endosomal Channel TPC1 Found to Regulate Cellular Iron Absorption Mechanism
Iron metabolism disorders—ranging from hereditary hemochromatosis to chronic anemia—affect hundreds of millions of…
Studies
Small-Molecule AT1R Agonist Challenges Decades of Cardiovascular Drug Design
For decades, the pharmacological playbook for the angiotensin II type 1 receptor has been written in one direction…
Nutrition
Early Sugar Restriction Cuts Adult Cancer Risk via Slowed Biological Aging
The conventional focus on adult dietary habits may be missing a far more consequential window: the first years of…
Nutrition
Broken Liver Clock Protein Explains Why Keto Backfires in Metabolic Disease
The ketogenic diet has become one of the most debated nutritional interventions in metabolic medicine — praised for…
Nutrition
Maternal Vitamin A Intake Explains Why STRA6 Eye Mutations Vary in Severity
For decades, clinicians have puzzled over why two patients carrying identical mutations in the same gene can present…
Studies
Calcium Pump Dysregulation Links TMC1 Mutations to Hair Cell Death in Deafness
Understanding why inherited deafness progresses so predictably — and potentially how to slow it — has long been a goal…
Studies
CIP2A–TOPBP1 Complex Found to Govern DNA Break Repair During Cell Division
Maintaining genomic integrity during cell division is one of the most demanding tasks biology faces — and failures…
Studies
Bladder Sensory Nerves Directly Detect Bacterial Infection and Accelerate Clearance
For the millions of adults who suffer recurrent urinary tract infections, treatment has long focused on antibiotics…
Nutrition
Global Consensus List Clarifies Which Microbes Are Safe in Food
For decades, the boundary between beneficial and potentially harmful microorganisms in the food supply has remained…
Nutrition
Dietary and Behavioral Shifts Cut BPA and Phthalate Levels Measurably
For adults concerned about hormonal health, metabolic function, and reproductive outcomes, the question has shifted…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB and HIV Co-Infection Trends 1990–2023
Tuberculosis remains one of the most consequential infectious diseases in human history, yet its burden is unevenly…
Studies
Genomic Map of 24 Childhood Immune Diseases Reveals 15 New Loci with Therapeutic Potential
Understanding why some children develop autoimmune arthritis, inflammatory bowel disease, or allergic conditions—while…
Nutrition
AI Portion Estimation Falls Short of Atlas-Assisted Human Accuracy in Central Asian Foods
Precision nutrition hinges on one deceptively simple problem: knowing how much someone actually ate. Dietary…
Studies
REST Protein Deficiency May Drive Brain Cell Fate Imbalance in Down Syndrome
Understanding why the Down syndrome brain develops with fewer neurons and excess glial cells has been one of…
Nutrition
43 Blood Metabolites Link Ultra-Processed Foods to Cardiovascular Death Risk
Understanding precisely how ultra-processed foods damage the cardiovascular system has long been a missing piece in…
Longevity
GLP-1 Weight Loss Beyond 20% Associated with Skin Sagging in 72% of Patients
Among 1,226 patients enrolled in a virtual cardio-kidney-metabolic program, dermatologic side effects of GLP-1…
Longevity
Unfavorable Social Conditions Amplify Mortality Risk 75% in Early Menopause
For women who experience menopause before age 45, the biological clock is already working against them — but new…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For people managing type 2 diabetes without medication, a triple-action hormone receptor agonist may represent a…
Studies
Glucose-Driven Protein Modification Triggers Cardiac Cell Death Pathway in Diabetes
Diabetic cardiomyopathy remains one of the most underappreciated contributors to cardiovascular mortality in people…
Studies
Evolutionary Sequence Modeling Uncovers Hidden Functional Sites in Cav1.3 Calcium Channel
Understanding precisely where a calcium channel can break — and why — has direct implications for interpreting the…
Studies
Dual Protein Markers ADGRG1 and CD86 Pinpoint Cancer-Fighting CD4+ T Cells
Identifying which immune cells to harvest and expand for personalized cancer therapy has long been the bottleneck…
Studies
Structural Map of Non-Canonical Inflammasome Reveals Dynamic Heterogeneity
Understanding how the body's inflammatory machinery assembles at the molecular level could eventually reshape how…
Studies
Palmitoylation of TK1 Exacerbates Osteoarthritis via JNK-Mediated Metabolic Reprogramming in Preclinical Models
For the estimated 500 million people living with osteoarthritis worldwide, the absence of any approved therapy capable…
Studies
KRI1-NPM1 Co-Phase Separation Drives Liver Cancer via Nucleolar Mechanics
Understanding why hepatocellular carcinoma (HCC) resists so many treatment strategies has long frustrated oncologists…
Nutrition
Prenatal Exposome-Microbiota Axis Linked to Infant Health Outcomes in Large Cohort
Understanding how the womb environment programs an infant's biological future is one of the most consequential…
Nutrition
Industrial Poultry Expansion Accelerates Campylobacter Evolution and Human Spread
Food safety discussions often focus on contamination events, but a more consequential story may be unfolding at the…
Nutrition
Plant Protein Fragments Reach Colon Intact in Mice, Supporting Healthy Gut Metabolite Profiles with Plant-Based Diets
For decades, dietary fiber has claimed nearly all the credit when scientists try to explain why plant-heavy diets…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB and HIV Overlap Quantified
Tuberculosis remains one of the most consequential infectious diseases on earth, yet its true toll — stratified by HIV…
Fitness
Caregiver Exercise Habits Show 13-Fold Link to Down Syndrome Family Activity
For the millions of families supporting someone with Down syndrome, household lifestyle patterns may matter far more…
PREPRINTNutrition
Food Marketing Associated with ~35 Extra kcal Intake in Children, TV Ads Linked to 44.5 kcal (Meta-Analysis)
Across 55 controlled studies enrolling 6,877 children and adolescents (ages 2–18), food and non-alcoholic beverage…
Studies
Gut Bacterium Ruminococcus bicirculans Boosts Lactosylceramide 24:1, Improving Insulin Signaling
Among 784 pregnant women in the Tongji-Huaxi-Shuangliu Birth Cohort — 222 of whom developed gestational diabetes…
Nutrition
Three Healthy Diet Patterns Associated With Reduced Dementia Risk in Older Adults With Alzheimer Pathology
Cognitive decline remains one of the most feared consequences of aging, yet pharmacological options for prevention…
Studies
Liraglutide Cuts Post-Bariatric Caloric Intake 162 kcal in Adolescents
For the significant minority of adolescents who regain weight or fail to reach healthy BMI targets after bariatric…
Wellbeing
Tau Research Consensus 2025: Biomarkers and Degradation Pathways Lead Therapeutic Advances
For the roughly 50 million people living with dementia worldwide — and the larger population at risk — the pace of…
Studies
Liquid Biopsy Biomarkers Converge Toward Earlier, Less Invasive Breast Cancer Detection
Early detection remains the single strongest predictor of breast cancer survival, yet current screening tools carry…
Studies
Vitamin B2 Metabolite FAD Acts as Dual Brake on Innate Immune Sensors
The idea that a core metabolic cofactor—one derived from dietary riboflavin and present in virtually every human…
Studies
Type 2 Diabetes Shows No Greater Bone Microarchitecture Decline Over Eight Years
Elevated fracture risk in people with type 2 diabetes is well documented, yet the cellular and structural mechanisms…
Studies
TB Deaths Fell Substantially Since 1990, But MDR-TB and HIV Gaps Widen (GBD 2023)
Three decades of progress against tuberculosis are real but dangerously incomplete — and recent collapses in global…
Studies
Salvianolic Acid Adjuvant Reduces BBB Disruption During Late-Window Stroke Thrombolysis
Hemorrhagic transformation after late-window thrombolysis remains one of the most feared complications in acute…
Studies
Circulating GPNMB Protein Predicts Immunotherapy Failure in Esophageal Cancer
With nearly 70% of esophageal squamous cell carcinoma patients failing to benefit from neoadjuvant immunotherapy, the…
Studies
Fluid Biomarkers Reshape Alzheimer's Diagnosis Before Symptoms Appear
For decades, Alzheimer's disease was diagnosed primarily through cognitive decline — meaning intervention came only…
Supplements
pH-Responsive Starch Granules Deliver Ellagic Acid Deep Into Small Intestine
Ellagic acid sits in a frustrating paradox for nutrition researchers: it carries meaningful antioxidant and…
Wellbeing
Early-Life Inflammation Primes Brain Immune Cells for Adult Depression via BAG3
The idea that adult depression can be partially shaped by events occurring in the first days of life challenges a…
Studies
Mathematical Model Captures MS Relapse Cycles via Hopf Bifurcation Dynamics
Multiple sclerosis affects nearly 2.9 million people worldwide, yet its relapsing-remitting cycles remain poorly…
Nutrition
Taste and Smell Genetics May Unlock Personalized Dietary Interventions
Why two people following identical diets can have vastly different outcomes has long puzzled nutrition scientists…
Studies
Antibody-Light Conjugate Eliminates Key Periodontal Pathogen Without Disrupting Oral Microbiome
The ability to surgically target a single bacterial species within a complex microbial community — without collateral…
Studies
Daraxonrasib Resistance Mechanisms Illuminate Combination Therapy Paths in Pancreatic Cancer
Pancreatic cancer remains one of oncology's most intractable challenges, with five-year survival rates stubbornly…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls Before 2035 Target
Tuberculosis remains one of humanity's most consequential infectious disease failures — a curable disease that still…
Nutrition
First-1000-Days Sugar Restriction Linked to 27–46% Lower Dementia Risk Decades Later
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
PREPRINTLongevity
Neighborhood Gun Violence Associated with 0.5% Lower Endothelial Function in Black Teens, with Diet and Adiposity as Mediators
In a prospective cohort of 400 Black adolescents from lower-income Chicago households, exposure to neighborhood gun…
Longevity
Smoking and Aging Share 85 Gut Microbiome Signatures Linked to ASCVD Risk
Analyzing 6,676 participants from the Guangdong Gut Microbiome Project, this cross-sectional study identified 222 OTUs…
Longevity
Fibrillarin-SIRT1 Axis Blocks Tumor Senescence via NAD+ Metabolism in ESCC
In esophageal squamous cell carcinoma (ESCC) patient cohorts, high intratumoral expression of fibrillarin (FBL), a…
Studies
GLP-1 Drug Cessation Triggers Metabolic Adaptations That Accelerate Weight Regain
For the millions now using semaglutide or tirzepatide, the harder question isn't how to lose weight — it's what…
Studies
RNA-Binding Protein MBNL1 Drives Leukemia via Direct DNA Enhancer Hijacking
A previously unrecognized molecular mechanism in an aggressive blood cancer subtype may open a new class of…
Fitness
Prolonged Uninterrupted Sitting Associated with 9% Higher Cancer Mortality Risk Per Hour
How sedentary time is structured — not just its total duration — may matter as much as how much time is spent sitting…
Supplements
Niosomal Gallic Acid Reduces Fatty Liver Markers Via Dual Pathway Modulation in Rats
Nonalcoholic fatty liver disease remains one of the most underappreciated consequences of obesity, and the chronic…
Studies
LRRK2 Parkinson's Kinase Maps to Centrosome Network via Proximity Proteomics
Understanding how a key Parkinson's disease protein organizes its cellular partnerships could reshape how researchers…
Studies
Iptacopan Halves Kidney Function Decline Rate in Phase 3 IgA Nephropathy Trial
For the roughly 1 in 500 adults who carry an IgA nephropathy diagnosis, the trajectory toward dialysis or transplant…
Studies
CAC Zero Score Does Not Eliminate Risk When Lipoprotein(a) Is Elevated
For years, a coronary artery calcium score of zero has been used as a powerful reassurance tool — effectively a…
Longevity
Metainflammation Bridges Preclinical Obesity to CVD via 3 Interdependent Mechanisms
A conceptual framework from Heilongjiang University positions metainflammation — chronic low-grade inflammation…
Studies
FL118 Molecular Glue Degrades Two Cancer Proteins Simultaneously in Hard-to-Treat Tumors
For cancers that resist nearly every available treatment — glioblastoma, pancreatic ductal adenocarcinoma, metastatic…
Studies
Protein Interaction Networks Emerge as Precision Targets in Ischemic Stroke Therapy
Ischemic stroke remains one of the leading causes of death and long-term disability worldwide, yet the therapeutic…
Nutrition
14-Year Guangxi Data Links Folic Acid Compliance to 97% NTD Correlation Drop
Neural tube defects remain one of the most preventable categories of congenital disability worldwide, yet gaps in…
Studies
Life-Course Framework Reframes Type 2 Diabetes Prevention Before Dysglycemia Sets In
The conventional approach to type 2 diabetes prevention — intervening once blood sugar is already trending abnormal…
Nutrition
Review Identifies Six Molecular Pathways Linking Gut Microbiota to Immune Programming
Understanding precisely how the gut microbiome shapes immunity—not just that it does—is now one of the most…
Studies
CDK9 Inhibition Targets Transcriptional Addiction in Blood Cancers
For patients with blood cancers that resist standard therapies, the challenge has long been that malignant cells…
Studies
CFTR Modulator Pharmacokinetics Shift Significantly in Pediatric Liver Disease
For children with cystic fibrosis who also develop advanced liver disease, treatment options narrow considerably — and…
Studies
66 Radionuclide-Drug Conjugates Mapped for Lung Cancer Precision Targeting
Lung cancer kills more people annually than any other malignancy, and the persistence of drug resistance alongside…
Studies
Largest Proteogenomic Map Links 24,000 Genetic Variants to Disease Drug Targets
When the same genetic variants that regulate circulating proteins also associate with disease risk, researchers gain…
Fitness
Resistance Training Boosts Muscle Quality SMD 0.61 in Older Adults
Across 41 randomized controlled trials encompassing 3,141 adults aged 60 and older, resistance exercise emerged as the…
Studies
Poor Sleep Associated with Depleted Levels of Gut Bacterium Eubacterium CAG:251 in 869 Older Adults
Among 869 older adults (mean age 70.7) in the Baltimore Longitudinal Study of Aging, both subjective insomnia symptoms…
Longevity
JAK Inhibitor Ruxolitinib Blocks Radiation-Induced Bone Loss via SASP Suppression
Ruxolitinib, a clinically approved JAK1/2 inhibitor, administered early and intermittently during radiotherapy…
Studies
Complete Rat Telomere-to-Telomere Genome Unlocks Structural Variation Across Eight Strains
For decades, incomplete reference genomes have quietly undermined the precision of biomedical research conducted in…
Longevity
GLP-1 Agonists in Elderly: Cardioprotection vs. Muscle Loss Trade-Off
A clinical commentary in Trends in Endocrinology and Metabolism raises a pointed concern about GLP-1 receptor agonist…
Studies
Neurocan Depletion in Prefrontal Cortex Disrupts GABAergic Circuits and Cognitive Flexibility
A protein woven into the brain's structural scaffolding may play a more active role in cognition than previously…
Studies
Combining Three CSP Epitopes Closes Malaria Vaccine Protection Gaps
Malaria remains one of the deadliest infectious diseases globally, killing hundreds of thousands of children annually…
Longevity
40 Years of Data: Loneliness Linked to Immune Aging via Gut-Inflammation Pathways in Kiecolt-Glaser Review
Four decades of psychoneuroimmunology research from Kiecolt-Glaser's lab at Ohio State establishes a robust causal…
Studies
Higher Early Respiratory Infection Burden Linked to Reduced Childhood Eczema Risk
The assumption that keeping infants healthy means shielding them entirely from infection may warrant reconsideration…