PREPRINTNutrition
DASH Diet Adherence Among Hypertensive US Adults Dropped 16% by 2018
Among 14,163 US adults with self-reported hypertension drawn from NHANES cycles 2003–2018, adherence to the DASH diet…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTSupplements
Lab4 Probiotic Cuts GP Visits by 52% in Healthcare Workers—But Trial Too Small
In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently…
PREPRINTWellbeing
Temperature-Regulated Sleep Surface Adds 33 Minutes of Sleep in Most Sleep-Deprived Adults
Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep…
PREPRINTNutrition
Diet-as-Medicine App Cuts Blood Pressure 5.5 mmHg After Correcting Statistical Bias
A retrospective cohort study of 329 US adults with obesity enrolled in a commercial digital food-as-medicine program…
Fitness
Resistance Training After Weight Loss Prevents T2D Risk Rebound at 1 Year
Among 221 sedentary women with overweight (mean BMI 28.3), an 800 kcal/day diet drove BMI to 23.9, slashing predicted…
Supplements
Oral Semaglutide Cuts Body Weight 10.5% in 28 Weeks, Shrinks Liver Fat
In a 28-week randomized controlled trial of 116 non-diabetic adults with obesity or overweight plus comorbidities…
Studies
MASLD + High Lp(a) Doubles Cardiovascular Risk in Multi-Ethnic Cohort
In a secondary analysis of the Multi-Ethnic Study of Atherosclerosis (MESA), adults with metabolic…
Fitness
Unstructured Daily Movement Cuts Depression and Blood Pressure in 8,551 Adults
Across 38 randomized controlled trials enrolling 8,551 adults, interventions that wove physical activity into daily…
Nutrition
Dietitian-Led Nutrition Beats Standard Advice for Cirrhosis Sarcopenia: RCT
In a 180-patient randomised controlled trial of decompensated cirrhosis with sarcopenia, six months of…
Fitness
12-Week RT+HIIT Shows Minimal Transcriptomic Gains; Polyphenols Add Nothing
A 12-week supervised concurrent resistance training plus HIIT programme in 38 adults aged 55–70 years produced…
Longevity
18-Month Exercise-Nutrition Program Slows Cognitive Decline in Targeted Older Adults
An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
Nutrition
Dietetic Counseling Cuts Systolic BP 5–7 mmHg; Wearables Add Modest Pulse Pressure Benefit
In a 954-person, three-arm RCT of adults aged ≥55 with metabolic syndrome risk factors, all intervention groups…
Fitness
151 Genes Linked to Muscle Strength Preservation During 2-Year Calorie Restriction
A secondary transcriptomic analysis of the landmark CALERIE randomized controlled trial — a 2-year caloric restriction…
Wellbeing
Social Isolation After Stroke Raises CVD Death Risk 57%, Loneliness Doubles Dementia
Among 7,267 stroke survivors in the UK Biobank followed for a median 10.2 years, social isolation independently raised…
Nutrition
Ultra-Processed Foods Raise Stroke Death Risk 21% Per 10-Point Increase in MI Survivors
In 4,365 post-myocardial infarction patients followed for a median 14 years in the Dutch Alpha Omega Cohort, each…
Studies
Bariatric Surgery Neurological Risk: 1.4–16% Incidence, Thiamine Deficiency Dominates
Across 12 studies encompassing more than 5,000 bariatric surgery patients, neurological complication rates ranged from…
Wellbeing
Healthy Sleep Cuts Stroke Risk 14% Via Lipid and Inflammation Pathways
In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component…
Studies
Weekly Dual GIP/Glucagon Agonist Cuts Weight Significantly in Obese Diabetics
The convergence of obesity and type 2 diabetes represents one of the most consequential metabolic challenges in modern…
Nutrition
Heart-Healthy Diet Cuts Fatty Liver Odds by 84% in Iranian Adults
In a case-control study of 675 Iranian adults (225 NAFLD cases, 450 controls), those scoring in the highest tertile of…
Nutrition
Personalized Dietary Plans Beat Usual Care for MASLD Weight Loss by 6.7 kg
Across 14 randomized controlled trials enrolling 1,805 adults with metabolic dysfunction-associated steatotic liver…
PREPRINTStudies
CGM-Detected Glucose Spikes Raise Liver Scarring Risk 28–59% in Non-Diabetics
In 1,071 adults from the Framingham Heart Study Third Generation cohort (mean age 60.2, BMI 28.2, 56% normoglycemic)…
PREPRINTNutrition
Erythritol and Xylitol Show No Platelet-Activating Effect in Crossover Trial
A randomized, single-blind crossover trial in 14 healthy adults tested whether acute oral doses of erythritol (50 g)…
Nutrition
Gut Butyrate Producers Determine Whether Protein Aids Post-Stroke Recovery
In 152 older stroke patients (mean age 78.4 years) undergoing inpatient rehabilitation, the benefit of dietary protein…
Studies
SGLT2 Inhibitors Show No Clear Anti-Inflammatory Effect Across 47 Trials
Pooling 47 randomized controlled trials, SGLT2 inhibitor therapy produced no statistically significant reductions in…
Nutrition
CBT-Enhanced Liver Program Cuts Cardiovascular Events 64% in Fatty Liver Disease
A randomized controlled trial of 286 adults with metabolic dysfunction-associated steatotic liver disease (MASLD)…
Studies
Oral GLP-1 Pill Cuts HbA1c 1.45% in Drug-Naive Type 2 Diabetes
Injectable GLP-1 receptor agonists have transformed metabolic medicine, but needle aversion and cold-chain logistics…
PREPRINTNutrition
Oat Milk Delivers Far Fewer Amino Acids Than Dairy, Even With Added Pea Protein
In a randomized crossover trial, 12 healthy men consumed 750 ml of semi-skimmed dairy milk, a standard oat-based drink…
Nutrition
KCl Tablets Cut Systolic BP ~8 mmHg by Flushing Hidden Tissue Sodium
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
PREPRINTNutrition
High Omega-3 Index Linked to 4.7-Year Younger Biological Age in 4,863 Adults
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…
PREPRINTFitness
Five Proteins Predict Which Heart Failure Patients Gain Most from Exercise Rehab
In 243 older adults (≥60 years) hospitalized for heart failure and enrolled in the REHAB-HF trial, pre-intervention…
Nutrition
Mediterranean Diet Cuts Ferritin 22 ng/mL in Metabolic Syndrome Over 32 Weeks
A 32-week, 30%-energy-deficit Mediterranean-style intervention in 190 overweight adults revealed that ferritin…
Nutrition
Soy Diet Cuts Hot Flash Frequency But Evidence Remains Very Low Certainty
Across 15 randomized controlled trials enrolling 1,952 women aged 40–65, soy-based dietary interventions produced a…
Nutrition
Low Fish, Legumes, and Fruit Intake Linked to 4-6x Higher MASLD Odds
In a case-control study of 111 adults attending a diet clinic in Turkey, consuming less than one fish serving per week…
Nutrition
8-Month Nutrition Education Cuts Cholesterol, BMI in Family Farmers
An 8-month nutrition education intervention across 7 structured sessions improved diet quality scores in 81 Brazilian…
Longevity
Deleting Lsp2 Gene Extends Drosophila Lifespan Via mTORC1-TOP mRNA Axis
In Drosophila, genetic ablation of Lsp2 — a protein previously classified only as a larval storage protein but now…
Wellbeing
Chronic Stress + Poor Habits Triple Mortality Risk in Fatty Liver Disease
Among 9,761 NHANES participants followed for a median of 7.42 years, 32.4% carried a diagnosis of metabolic…
Nutrition
Diet Drives 40% of Colorectal Cancer Deaths; Burden Rising to 2030
Analysis of Global Burden of Disease 2023 data across G20 nations spanning 1990–2023 finds that dietary risks account…
Nutrition
70% Plant Protein Diet Cuts TMAO by 4.6 μg/mL in Advanced CKD Patients
In a 4-week randomized controlled trial of 36 Japanese patients with severely impaired kidney function (median eGFR 13…
Supplements
Probiotic Converts Citrus Compound to Activate Longevity Gene, Reversing Age-Related Metabolic Decline
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Longevity
High Uric Acid Triples Mortality Risk in Older Women: Cohort Data
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
Nutrition
Falling Plasma Erythritol Predicts Lower ASCVD Risk After Weight-Loss Diet
In 802 overweight or obese adults enrolled in the 2-year POUNDS Lost randomized trial, higher baseline plasma…
Nutrition
Higher Body Fat Drives Emotional Eating — Not the Reverse
In the Fenland cohort — a prospective UK study of middle-aged adults born 1950–1975 — higher baseline BMI and…
Fitness
Telerehabilitation Boosts VO₂ Peak by 2.58 mL/kg/min in Heart Disease Patients
Across 13 randomized controlled trials enrolling 958 adults with cardiovascular disease, exercise-focused…
Nutrition
Peanut-Induced Lipidome Shifts Cut Type-2 Diabetes Risk 11%, BMI Mediates 89%
A peanut-derived plasma lipidomic signature (PeLS), constructed by combining lipid changes observed in a 6-month…
Nutrition
Healthy Plant-Based Diet Lowers Blood Pressure and Cholesterol in 8-Year-Olds
Among 3,990 children in the Dutch Generation R cohort, a higher healthful plant-based diet index (hPDI) score at age 8…
Nutrition
Nordic Diet Cuts 24-Year Mortality Risk by 2.67% But Misses Liver Disease
Across two Swedish population-based cohorts totalling 64,406 middle-aged and older adults, adherence to a Healthy…
Nutrition
Keto Beats Mediterranean Diet by 3.6 kg for Weight Loss in RCT Meta-Analysis
Pooling randomized controlled trials comparing ketogenic (KD) and Mediterranean diets (MD) head-to-head in adults…
Nutrition
Glycine and LDL Cholesterol Fraction Causally Linked to Two Lacunar Stroke Subtypes
Among 2,408 participants — 1,456 MRI-confirmed lacunar stroke cases and 952 hospital controls — Mendelian…
Supplements
3g Daily Fish Oil Cuts Ceramide-Based Heart Risk Score by 2.4 Points
In the 20-week MoKaRi randomized trial, adults with elevated LDL-C (≥3.0 mmol/L) not on lipid-lowering therapy who…
Nutrition
Vegetarian Older Adults Gain Muscle During Resistance Training, but Less Than Omnivores
In a 12-week randomized non-inferiority trial of 108 adults averaging 66 years old, both a lacto-ovo vegetarian and an…
Nutrition
8.8 Million Adults: Ultra-Processed Foods Raise Mortality Risk 18%
Across 51 prospective cohorts encompassing nearly 9 million adults, higher ultra-processed food (UPF) consumption was…
Longevity
Senescent Bone Cells' SASP Drives Osteoporosis via RANKL/Wnt/NF-κB Convergence
Senescent osteocytes, mesenchymal stem cells, osteoblasts, immune cells, and vascular endothelial cells collectively…
Studies
New Evolutionary Framework Explains How Host-Specific Microbiomes Become Heritable
Understanding why each animal species carries a distinct, heritable microbial community — and how that specificity is…
Studies
Beta-Catenin–TRIM28 Complex Controls Hormone-Driven Gene Transcription in Kidney Cells
Understanding how mature, fully differentiated cells regulate gene expression in response to hormones has direct…
Studies
Taste Receptor Structural Flexibility Explains Why Both Sugar Forms Taste Sweet
Understanding why the human tongue can detect such a broad chemical landscape using just a handful of receptors has…
Studies
Alternative Splicing of Syt7 Protein Acts as Master Switch for Synaptic Plasticity
Understanding how the brain fine-tunes communication between neurons has profound implications for neurological…
Longevity
Lysosomal Protein TM6SF1 Links Cholesterol Sensing to mTORC1 Nutrient Signaling
Understanding how cells detect nutrient availability and adjust growth accordingly sits at the heart of aging biology…
Studies
AMPylation Enzyme SelO Suppresses Tumors via Cdk5rap3 Protein Modification
Most cancer research focuses on familiar signaling pathways—phosphorylation cascades, ubiquitin-mediated degradation…
Studies
Oral OGA Inhibitor Ceperognastat Tested in Early Alzheimer's RCT
Tau pathology sits at the heart of Alzheimer's neurodegeneration, and the search for drugs that can interrupt its…
Studies
Tau-Targeting Drug Ceperognastat Enters Alzheimer Clinical Testing Phase
With amyloid-clearing therapies now approved for early Alzheimer's, the field's next frontier is tau — the protein…
PREPRINTNutrition
Feijoa Powder Cuts HbA1c by 0.5% in Prediabetic Adults Over 12 Weeks
A 12-week randomized controlled trial in 39 overweight adults with prediabetes (HbA1c 5.7–6.4%, BMI 25–29.9 kg/m²)…
PREPRINTNutrition
Poor Campus Food Access Raises Odds of Disrupted Meal Timing 9.5-Fold
Among 302 undergraduates (mean age 20 years, 68.9% female) at a Nigerian medical university, poor physical food…
Nutrition
0.5%/0.5% Lysine-Arginine Ratio Cuts Tumor Burden; Wrong Ratio Accelerates Growth
A specific dietary amino acid ratio — 0.5% lysine combined with 0.5% arginine — reduces tumor burden and extends…
Studies
Tapeworm Drug Niclosamide Disrupts Breast Cancer Survival Pathway, Boosts Chemo Sensitivity
Repurposing existing drugs for cancer treatment has emerged as one of oncology's most pragmatic frontiers — bypassing…
Studies
Integrated Early Intervention Boosts Growth in Undernourished Term Infants
Small-for-gestational-age infants born at term face a compounding disadvantage: they enter the world already behind on…
Studies
Integrated Four-Domain Intervention Boosts Weight Gain in Underweight Newborns
Catch-up growth in infants born small-for-gestational-age remains one of the most consequential challenges in early…
Studies
Bundled Nutrition and Stimulation Interventions Show Mixed Results for At-Risk Infants
For the roughly 250 million children in low- and middle-income countries who fail to reach key developmental…
Nutrition
Prepregnancy Iron Deficiency Screening May Protect Infant Neurodevelopment
Iron status before and during early pregnancy rarely attracts the same clinical attention as folate or gestational…
Studies
Catestatin Peptide Cuts Tau Pathology via Adrenergic Stress Suppression in Mice
A hormonal peptide already present in the human body may hold an overlooked key to slowing the molecular cascade…
Longevity
Grip Strength Decouples From Muscle Mass During Gene Therapy: NMJ Is Why
For anyone tracking longevity interventions, grip strength has long been treated as a reliable proxy for biological…
Studies
Phase 3 PET Trial Tests Novel Radiotracer for Multi-Subtype Cardiac Amyloidosis Detection
Cardiac amyloidosis has long been one of medicine's underdiagnosed threats — a condition that silently stiffens the…
Studies
Gene Therapy Corrects Fatal Immune Defect in Children Without Matched Donor
For children born with a rare and often lethal immune disorder, a viable treatment has historically depended on…
Studies
DHDDS Mutation Impairs Brain Glycosylation, Depletes Interneurons, Triggers Seizures
When a single faulty copy of one gene quietly derails a fundamental biochemical pathway, the downstream consequences…
Longevity
PKU Accelerates Aging via Oxidative Stress and Mitochondrial Dysfunction
For decades, early dietary intervention in phenylketonuria was considered sufficient to normalize life outcomes. A…
Studies
Engineered Probiotic Targets Colorectal Tumors by Blocking Wnt Signaling Pathway
Colorectal cancer kills roughly 900,000 people annually, and its treatment landscape has changed little in over a…
Longevity
Neural Disconnection in Aging Muscle: How Denervation Drives Strength Loss
Strength loss in older adults is rarely attributed to the nervous system, yet the progressive disconnection of motor…
Studies
LRRC8A Protein Loss in Arterial Muscle Cells Triggers Blood Pressure-Lowering Cascade
Hypertension remains one of the most modifiable risk factors for cardiovascular disease and stroke, yet the molecular…
Longevity
Menopause Proteomics Reveal Hormone-Driven Molecular Signatures Tied to Later Dementia Risk
For decades, the connection between menopause and accelerated cognitive decline has been clinically observed but…