Longevity
Single-Subject DELTA Protocol Integrates TRE, Mediterranean Diet, and AI Biomarkers for Healthspan
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
NR Fumarate Salt Raises Blood NAD+ at 3× Lower Dose Than NMN or NR Chloride
A proprietary crystalline salt form of nicotinamide riboside — NR fumarate, branded Restorin NR — achieved blood NAD+…
Supplements
Narrative Review: GLP-1 Receptor Agonists May Improve Testosterone and Erectile Function Beyond Weight Loss
GLP-1 receptor agonists (GLP-1RAs) — originally developed for type 2 diabetes and now dominant obesity pharmacotherapy…
Supplements
Genomic Map of 287 Ginseng Accessions Unlocks Ginsenoside Biosynthesis Pathway
For anyone who takes ginseng supplements or follows adaptogen research, a fundamental question has lingered: why do…
Nutrition
Broken Liver Clock Protein Explains Why Keto Backfires in Metabolic Disease
The ketogenic diet has become one of the most debated nutritional interventions in metabolic medicine — praised for…
Nutrition
Global Consensus List Clarifies Which Microbes Are Safe in Food
For decades, the boundary between beneficial and potentially harmful microorganisms in the food supply has remained…
Studies
Late-Life Hormone Therapy Linked to Mixed Cancer and Cardiovascular Outcomes in Large Cohort
For millions of postmenopausal women managing chronic symptoms well into their sixties and beyond, the question of…
Longevity
Hyperfunction Theory Reframes Aging as Programmatic Overdrive, Not Damage Accumulation
Most people assume the body simply wears out — accumulating molecular errors until systems fail. A compelling…
Studies
20-HETE Lipid Mediator Predicts ICU Admission Risk in COVID-19 Patients
Understanding why some COVID-19 patients deteriorate to critical illness while others recover with mild symptoms has…
Studies
Two-Thirds of US Women Enter Pregnancy With Preventable Risk Factors
Most conversations about prenatal health focus on the nine months of pregnancy, yet the biological groundwork for…
Supplements
C15:0 Fatty Acid Docks mTOR at -4.4 kcal/mol, Suggesting Fertility-Safe Rapamycin Alternative
Chronic mTOR hyperactivation drives ovarian aging through suppressed autophagy, mitochondrial dysfunction, impaired…
Longevity
RSV Vaccine Uptake Gap in Older Adults Undermines Healthy Aging Goals
For older adults, maintaining independence and avoiding hospitalization are defining health priorities — yet a highly…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For people managing type 2 diabetes without medication, a triple-action hormone receptor agonist may represent a…
Studies
Fingertip Sweat Patch Tracks Levodopa Levels Without Power or Blood Draws
For the roughly one million Americans living with Parkinson's disease, the difference between a functional day and a…
Studies
Gut Bacterium Ruminococcus bicirculans Boosts Lactosylceramide 24:1, Improving Insulin Signaling
Among 784 pregnant women in the Tongji-Huaxi-Shuangliu Birth Cohort — 222 of whom developed gestational diabetes…
Studies
Hip Fracture Risk, Recovery, and Prevention: What the Evidence Shows
For older adults and their families, few injuries carry higher stakes than a hip fracture — yet the gap between best…
Studies
First FDA-Approved Drug Cuts Acute Pancreatitis Risk in Severe Hypertriglyceridemia
Elevated triglycerides represent one of the more underappreciated cardiovascular and metabolic threats in clinical…
Studies
Midwifery and Doula Care Linked to Better Birth Outcomes for Black Women
Black women in the United States carry a disproportionate burden of maternal mortality and morbidity — a crisis that…
Studies
Unpredictable Symptoms and Workplace Stigma Identified as Key Barriers to Long COVID Return-to-Work
For millions of working-age adults living with post-COVID condition, the gap between wanting to work and being able to…
Studies
Folic Acid Prevents Neural Tube Defects Via Retinoic Acid Enzyme ALDH1L1
For decades, the advice to take folic acid before and during early pregnancy has rested on remarkably strong…
Studies
Type 2 Diabetes Shows No Greater Bone Microarchitecture Decline Over Eight Years
Elevated fracture risk in people with type 2 diabetes is well documented, yet the cellular and structural mechanisms…
Supplements
pH-Responsive Starch Granules Deliver Ellagic Acid Deep Into Small Intestine
Ellagic acid sits in a frustrating paradox for nutrition researchers: it carries meaningful antioxidant and…
Longevity
Knee OA Reframed as Joint Aging: GAE and Senescence Targets Evaluated
A structured narrative review spanning PubMed/MEDLINE and Embase (2010–2026) positions knee osteoarthritis not as a…
Nutrition
First-1000-Days Sugar Restriction Linked to 27–46% Lower Dementia Risk Decades Later
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
Longevity
Fibrillarin-SIRT1 Axis Blocks Tumor Senescence via NAD+ Metabolism in ESCC
In esophageal squamous cell carcinoma (ESCC) patient cohorts, high intratumoral expression of fibrillarin (FBL), a…
Longevity
Aging Stem Cells Hijack Immune Memory to Drive Chronic Inflammation via SIRT3 Loss
Chronic low-grade inflammation — inflammaging — has long been recognized as a root driver of age-related disease, but…
Supplements
Niosomal Gallic Acid Reduces Fatty Liver Markers Via Dual Pathway Modulation in Rats
Nonalcoholic fatty liver disease remains one of the most underappreciated consequences of obesity, and the chronic…
Studies
LRRK2 Parkinson's Kinase Maps to Centrosome Network via Proximity Proteomics
Understanding how a key Parkinson's disease protein organizes its cellular partnerships could reshape how researchers…
Nutrition
14-Year Guangxi Data Links Folic Acid Compliance to 97% NTD Correlation Drop
Neural tube defects remain one of the most preventable categories of congenital disability worldwide, yet gaps in…
Nutrition
Review Identifies Six Molecular Pathways Linking Gut Microbiota to Immune Programming
Understanding precisely how the gut microbiome shapes immunity—not just that it does—is now one of the most…
PREPRINTStudies
362 Physicians Reveal Dangerous Gaps in Hyperkalemia Care Across 7 Nations
A cross-sectional survey of 362 physicians across seven Central American countries and the Dominican Republic reveals…
Fitness
Resistance Training Boosts Muscle Quality SMD 0.61 in Older Adults
Across 41 randomized controlled trials encompassing 3,141 adults aged 60 and older, resistance exercise emerged as the…
Studies
Screening Ultrasound After Negative Tomosynthesis: 98.5% False-Positive Rate Quantified
For women with dense breasts, the decision to add ultrasound screening on top of a negative mammogram carries real…
Supplements
Oral GLP-1 Drugs Deliver 11–12% Weight Loss Without Injections in Non-Diabetics
A frequentist random-effects network meta-analysis pooling 9 RCTs (N = 5,766; durations 20–72 weeks) compared four…
Studies
Omega-3 Plus Low-Dose Aspirin Rivals Antibiotics for Severe Periodontitis
For the millions of adults living with severe gum disease, the assumption that antibiotics are the gold standard…
Studies
D-Serine Suppresses Anti-Tumor Immunity by Rewiring Macrophage Signaling
Understanding why some cancer patients fail to respond to immunotherapy is one of oncology's most pressing puzzles. A…
Supplements
Creatine 300mg/kg Cuts TBI Lesion Volume 60%, Blocks Epileptiform Activity via Na⁺/K⁺-ATPase
Post-injury oral creatine at 300 mg/kg for two weeks produced striking neuroprotection in adolescent rats subjected to…
Supplements
GLP-1 Weight Loss Includes 25–39% Lean Mass Loss, Similar to Diet: CKM Patients Face Sarcopenia Risk
Across incretin-based therapies — GLP-1 receptor agonists and dual GLP-1/GIP agonists like semaglutide and tirzepatide…
Supplements
30B CFU Daily Probiotic Boosts Happiness 12.7%, Cuts IL-6 20% in Older Adults
Eight weeks of daily supplementation with 30 billion CFU of Pediococcus acidilactici PA53 in 75 adults aged 55–70…
Studies
Brazilian RA Patients Rank Pain, Diet, and Rights as Top Education Gaps
For the roughly 1.5 million Brazilians living with rheumatoid arthritis, knowing what to ask a doctor can be as…
Studies
Robotic Abdominal Surgery Linked to Lower Post-Op Inflammatory Markers Than Laparoscopy
For colorectal cancer patients, the intensity of the body's post-surgical inflammatory surge may be as consequential…
Studies
Meta-Analysis: Standard-Dose Psilocybin Doubles Depression Response Rates vs Controls
Depression treatment has long been plagued by inadequate remission rates — roughly half of patients fail first-line…
Studies
Epicardial Hypoxia Coordinates Heart Growth and Coronary Formation in Vertebrates
Understanding how the developing heart grows its own blood supply in perfect synchrony with muscle expansion has been…
Studies
Distinct Form of Fat Fibrosis Linked to Insulin Resistance in People with HIV
Even with modern antiretroviral therapy bringing HIV viral loads to undetectable levels, metabolic disease remains a…
Studies
SIRT7 Protein Shields Spinal Discs by Blocking NF-κB Inflammatory Cascade
Chronic back pain from spinal disc degeneration affects hundreds of millions globally, yet its molecular drivers…
Nutrition
Gut Microbiome Dysbiosis Patterns Linked to GI Cancer Progression and Treatment Targets
The relationship between the gut microbiome and cancer risk has moved well beyond correlation — emerging evidence now…
Nutrition
NEJM Case Report Links Chronic Inflammation to Dietary Consumption Pattern
Chronic systemic inflammation remains one of the most underappreciated drivers of disease burden in otherwise…
Studies
Conservative Oxygen Targets Post-Cardiac Arrest Show Meaningful Clinical Signal
For the roughly 350,000 adults who survive out-of-hospital cardiac arrest each year in high-income countries, the…
Studies
Six Viruses Linked to MS Onset via Shared Immune-Disruption Pathways
Multiple sclerosis affects nearly 2.9 million people globally, yet its root cause has resisted a clean explanation for…
PREPRINTNutrition
Boysenberry-Apple Blend Cuts Children's Cold Duration by 3 Days in RCT
A double-blind, randomized, placebo-controlled trial of 84 children aged 5–13 found that twice-daily chewable tablets…
Nutrition
Folic Acid's NTD Protection Traced to a Retinoic Acid Conversion Pathway
For decades, folic acid supplementation has been one of public health's most clear-cut wins — a simple intervention…
Studies
HSV-1 Reactivation Linked to Halved ICU Survival in COVID-19 Patients
For critically ill COVID-19 patients, the immune battles fought inside the ICU extend well beyond SARS-CoV-2 itself…
Nutrition
Methionine-Supplemented Low-Protein Diet Cuts Frailty While Boosting GLP-1 and FGF21
A low-protein longevity diet supplemented with methionine (LDMM) — modeled on traditional Mediterranean and Okinawan…
Studies
Vitamin D's Active Form Rewires Immune Progenitors Into Gut-Protective ILC3 Cells
For decades, vitamin D's immune benefits have been described in broad strokes — anti-inflammatory, gut-protective…
Studies
Meningococcal Vaccine Cuts Gonorrhea Risk 38% in Australian Adolescents
As gonorrhea rates climb globally and antibiotic resistance narrows treatment options, cross-protective immunity from…
PREPRINTStudies
LASr + LGE-CMR Combo Hits 91% AUC for AF Detection in Mitral Regurgitation
In 46 patients with moderate-to-severe degenerative mitral regurgitation (DMR), integrating left atrial reservoir…
Supplements
Ginkgo Biloba's Cardiovascular Mechanisms Mapped in Comprehensive Pharmacological Review
For adults seeking evidence-based approaches to cardiovascular protection, understanding exactly how botanical…
Studies
Oral GLP-1 Pill Plus Insulin Cuts HbA1c Beyond Insulin Alone
For the roughly half of insulin-treated type 2 diabetes patients who never reach their glycemic targets, the prospect…
Studies
Oral GLP-1 Agonist Plus Insulin Cuts HbA1c Beyond Insulin Alone
For the roughly one-third of people with type 2 diabetes who remain poorly controlled despite daily insulin…
Studies
Secret Shopper Study Exposes Clinical Gaps in Online GLP-1 Prescribing
The rapid proliferation of telehealth platforms offering weight-loss medications has outpaced regulatory oversight…
Studies
Consensus Guidelines Address GLP-1 Drug Safety Across Female Reproductive Lifecycle
As GLP-1 receptor agonists and other incretin-based therapies rapidly expand into mainstream obesity and diabetes…
Supplements
Ashwagandha's Dark Side: Liver, Thyroid, and Immune Risks Mapped
Ashwagandha has become one of the most popular adaptogens in Western wellness culture, marketed aggressively for…
Studies
AI Models Show Clinical Promise Depicting Depression-Linked Facial Aging Patterns
The intersection of psychiatric illness and visible physical aging is well-established in clinical medicine, yet…
Nutrition
Formula Unaffordability Linked to Unsafe Infant Feeding Practices in UK Families
When the cost of infant formula becomes prohibitive, families don't simply go without — they adapt in ways that…
Studies
ADT Resistance in Prostate Cancer Linked to HGF and WNT Pathway Activation
For the roughly one-third of men with advanced prostate cancer who eventually exhaust every available…
Nutrition
Short-Term High-Sugar Diet Worsens Allergic Asthma via Visceral Fat Inflammation
For the millions of adults managing asthma alongside modern Western diets, the timeline of dietary harm matters…
Studies
Triple Receptor Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Diabetes Trial
The incretin pharmacology arms race has a new contender with meaningful clinical data behind it. For the millions of…
Studies
Triple Receptor Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For the millions of adults managing type 2 diabetes with lifestyle modification alone, the pipeline of incretin-based…
Studies
Irradiated Tumor Fibroblasts Enter Senescence Yet Fuel Cancer Regrowth
Radiation therapy's failure to cure a third of advanced head and neck cancers has long puzzled oncologists, and this…
PREPRINTLongevity
Well-Controlled Diabetes Still Drives Subclinical Cardiac Damage Over 5 Years
Among 562 metabolic syndrome patients from the PREDIMED-Plus trial tracked over five years, diabetes status…
Supplements
Liraglutide Reshapes Gut Microbiome in 4 Days, Reverses Within a Week
In diet-induced obese C57BL/6J mice treated with liraglutide for 14 days, 16S rRNA sequencing of 7.1 million sequences…
Supplements
GLP-1 Agonists Linked to Lower Joint Replacement Infection Risk in Observational Studies
Preoperative use of GLP-1 receptor agonists — the drug class including semaglutide and liraglutide — is associated…
Studies
Foodborne Pathogens Kill 265,000 Annually With 7× Regional Mortality Disparity
The gap between what wealthy and low-income nations experience from contaminated food is not merely statistical — it…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Diabetes Trial
The landscape of type 2 diabetes pharmacotherapy may be about to shift again. While GLP-1 receptor agonists like…
Supplements
Herbal Formula BTS Cuts Collagen Gene Expression 60% in Aged Obese Mice
Organ fibrosis in older adults with obesity represents one of the most clinically underserved intersections of aging…
Longevity
Menopause-Specific Cardiovascular Risk Goes Undetected Without Dedicated Screening Programs
Cardiovascular disease remains stubbornly underprioritized in women's healthcare, partly because clinicians still…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Trial
For people managing early type 2 diabetes through diet and exercise alone, the ceiling on metabolic improvement may be…
Longevity
Senolytic, Epigenetic, and Metabolic Strategies Converge on Precision Longevity Medicine
The boundary between aging and treatable disease is collapsing — and how medicine responds to that shift will define…
Studies
Childhood Inflammation Markers Show No Causal Link to Molar Hypomineralisation
One of the most frustrating gaps in pediatric dental research has been the inability to explain why molar incisor…
Studies
Pyruvate Directly Modifies Histones at 88 Sites, Linking Glycolysis to Gene Expression
Every time a cell ramps up glycolysis — burning more glucose for energy — it may be simultaneously rewriting its own…