PREPRINTSupplements
Lab4 Probiotic Cuts GP Visits by 52% in Healthcare Workers—But Trial Too Small
In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTNutrition
Diet-as-Medicine App Cuts Blood Pressure 5.5 mmHg After Correcting Statistical Bias
A retrospective cohort study of 329 US adults with obesity enrolled in a commercial digital food-as-medicine program…
Supplements
Vitamin D Supplements Show Little Bone Benefit in Non-White Adults Across 8,000-Person Review
A systematic review and meta-analysis of 12 randomised controlled trials encompassing 8,023 adults from Black African…
Supplements
Oral Semaglutide Cuts Body Weight 10.5% in 28 Weeks, Shrinks Liver Fat
In a 28-week randomized controlled trial of 116 non-diabetic adults with obesity or overweight plus comorbidities…
Fitness
12-Week RT+HIIT Shows Minimal Transcriptomic Gains; Polyphenols Add Nothing
A 12-week supervised concurrent resistance training plus HIIT programme in 38 adults aged 55–70 years produced…
Studies
Bariatric Surgery Neurological Risk: 1.4–16% Incidence, Thiamine Deficiency Dominates
Across 12 studies encompassing more than 5,000 bariatric surgery patients, neurological complication rates ranged from…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
Wellbeing
Healthy Sleep Cuts Stroke Risk 14% Via Lipid and Inflammation Pathways
In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component…
Nutrition
Ultra-Processed Foods Raise Stroke Death Risk 21% Per 10-Point Increase in MI Survivors
In 4,365 post-myocardial infarction patients followed for a median 14 years in the Dutch Alpha Omega Cohort, each…
PREPRINTWellbeing
Six Lifestyle Clusters Predict Dementia Risk: Worst Combo Raises Hazard 2.4×
Among 151,832 UK Biobank participants aged 60–69, six distinct clusters of co-occurring modifiable risk factors were…
Nutrition
KCl Tablets Cut Systolic BP ~8 mmHg by Flushing Hidden Tissue Sodium
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
Studies
OAGB Cuts Long-Term Weight Regain Risk 66% vs Sleeve Gastrectomy
Across 1,498 adults followed for a median of 53–66 months after bariatric surgery, all three procedures achieved…
PREPRINTSupplements
Phosphatidylserine 300mg/day Misses Primary Memory Target but Hints at Working Memory Gains
A 12-week randomized, double-blind, placebo-controlled trial in 70 adults aged 35–65 with subjective memory complaints…
PREPRINTNutrition
High Omega-3 Index Linked to 4.7-Year Younger Biological Age in 4,863 Adults
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…
PREPRINTSupplements
Tirzepatide Cuts New Heart Failure Risk 10%, Mortality 20% vs Semaglutide in Obesity
In a propensity-score-matched retrospective cohort of 848,538 adults with obesity drawn from the TriNetX platform…
Nutrition
Low Fish, Legumes, and Fruit Intake Linked to 4-6x Higher MASLD Odds
In a case-control study of 111 adults attending a diet clinic in Turkey, consuming less than one fish serving per week…
Studies
Fracture-Prevention Drugs in Men: Cochrane Review Finds Thin Evidence
A Cochrane systematic review pooled 17 randomised controlled trials enrolling 4,132 men aged 50–73 to evaluate…
Longevity
High Uric Acid Triples Mortality Risk in Older Women: Cohort Data
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
Supplements
Probiotic Converts Citrus Compound to Activate Longevity Gene, Reversing Age-Related Metabolic Decline
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Fitness
Telerehabilitation Boosts VO₂ Peak by 2.58 mL/kg/min in Heart Disease Patients
Across 13 randomized controlled trials enrolling 958 adults with cardiovascular disease, exercise-focused…
Supplements
3g Daily Fish Oil Cuts Ceramide-Based Heart Risk Score by 2.4 Points
In the 20-week MoKaRi randomized trial, adults with elevated LDL-C (≥3.0 mmol/L) not on lipid-lowering therapy who…
Supplements
Vitamin D3 and Omega-3 Fail to Reduce Dementia Biomarkers Over 4 Years
Four years of daily supplementation with vitamin D3 (2000 IU) and marine omega-3 fatty acids (1 g) produced no…
Nutrition
Glycine and LDL Cholesterol Fraction Causally Linked to Two Lacunar Stroke Subtypes
Among 2,408 participants — 1,456 MRI-confirmed lacunar stroke cases and 952 hospital controls — Mendelian…
PREPRINTNutrition
Feijoa Powder Cuts HbA1c by 0.5% in Prediabetic Adults Over 12 Weeks
A 12-week randomized controlled trial in 39 overweight adults with prediabetes (HbA1c 5.7–6.4%, BMI 25–29.9 kg/m²)…
Studies
Bundled Nutrition and Stimulation Interventions Show Mixed Results for At-Risk Infants
For the roughly 250 million children in low- and middle-income countries who fail to reach key developmental…
Studies
Methodological Flaw Shadows Thrombectomy-Alteplase Trial's Recovery Claims
When a stroke trial changes its primary outcome midway through enrollment, the integrity of its central conclusion…
Studies
2025 Blood Pressure Guidelines Leave Millions Undertreated Despite Expanded Criteria
Hypertension remains one of the most modifiable risk factors for cardiovascular disease and stroke, yet a troubling…
Studies
Catestatin Peptide Cuts Tau Pathology via Adrenergic Stress Suppression in Mice
A hormonal peptide already present in the human body may hold an overlooked key to slowing the molecular cascade…
Supplements
Resveratrol Blocks Coal Dust Nanoparticle Fibrosis via Alveolar Cell Protection
Coal dust nanoparticles (CD-NPs) — the primary driver of pneumoconiosis — significantly reduced type II alveolar cell…
Studies
Engineered Probiotic Targets Colorectal Tumors by Blocking Wnt Signaling Pathway
Colorectal cancer kills roughly 900,000 people annually, and its treatment landscape has changed little in over a…
Wellbeing
Macromastia Linked to Higher Rates of Chronic Migraine and Sleep Apnea in Women
For women with breast hypertrophy, the burden of neurological symptoms may extend far beyond musculoskeletal…
Studies
Insulin Resistance Linked to Harder-to-Treat Depression in 30,000-Person Study
The metabolic-psychiatric interface is becoming one of the most clinically consequential frontiers in medicine, and…
Wellbeing
Severe Sleep Apnea Disrupts Brain's Nightly Restoration Mechanism, Study Finds
The brain's ability to reset itself overnight may be quietly eroding in millions of people with untreated sleep apnea…
Nutrition
One in Six Pediatric GLP-1 Users Develops Nutritional Deficiency Within a Year
As GLP-1 receptor agonists move rapidly from adult obesity clinics into pediatric practice, a critical question has…
Studies
Dried Blood Spot Screening for Congenital CMV Shows Critical Sensitivity Gap
Congenital cytomegalovirus is the most common non-genetic cause of childhood sensorineural hearing loss, affecting…
Studies
Hybrid AI Adaptation Outperforms Single-Strategy LLMs in Clinical Decision Support
The promise of AI-assisted medicine hinges not on raw model power but on how intelligently a language model is adapted…
Studies
Earlier Menarche Linked to 46% Higher Metabolic Syndrome Risk at Age 18
The window in which a girl enters puberty may quietly shape her cardiometabolic trajectory for years before any…
Supplements
Kratom's Opioid-Like Toxicity Resists Standard Naloxone Reversal Protocols
As botanical alternatives to opioids gain mainstream traction, emergency physicians are confronting a clinical problem…
PREPRINTNutrition
Spirulina-Bound Iron Doubles Serum Levels in 5 Hours With Near-Zero GI Side Effects
A spirulina-bound iron supplement (Monurelle Ferro Naturale) delivered to 12 iron-replete women over three consecutive…
Studies
Only 17% of Rural Ghanaian Health Workers Recognize Female Genital Schistosomiasis
A neglected tropical disease that mimics sexually transmitted infections is slipping through clinical nets in…
Wellbeing
69% of Juba Children Engaged in Risky Online Behavior, Study Finds
In post-conflict societies where mental health infrastructure is sparse and trauma exposure is already elevated…
Studies
QI Campaign Cuts Unnecessary Head CT Scans 20–23% in Low-Risk Trauma
Radiation exposure from CT imaging accumulates silently over a patient's lifetime, and emergency departments have long…
Supplements
Dual GLP-1/GIP Agonist BGM0504 Cuts Body Weight 18% in 24 Weeks
A phase 2 randomized controlled trial of 120 Chinese adults with overweight or obesity (no diabetes) tested…
Fitness
Ten-Minute Ultrasound Session Selectively Reduces Deep Soleus Stiffness
Muscle stiffness is a double-edged mechanical property: too much restricts range of motion and elevates strain-injury…
PREPRINTStudies
58.6% of Zambian Hypertension Patients Non-Adherent: Income, Age, Side Effects Drive Gap
At a primary health centre in Ndola, Zambia, only 41.4% of 237 hypertensive patients achieved adequate adherence to…
Supplements
Semaglutide Triggers Postmenopausal Bleeding via Adipose Estrogen Disruption
A 58-year-old postmenopausal woman developed new-onset vaginal bleeding six weeks after initiating semaglutide, with…
Supplements
Semaglutide Cuts Triglycerides 91% in Patient with 6 Pancreatitis Episodes
A 39-year-old man with catastrophically elevated triglycerides peaking at 2,329 mg/dL — nearly 13 times the upper…
Studies
3D-Printed Gut-on-a-Chip Enables Realistic Human-Microbe Interaction Studies
Understanding how gut bacteria interact with intestinal epithelium has long been constrained by the inadequacy of…
Studies
Depression Mediates 80% of Suicide Risk Link in Overactive Bladder
A chronic bladder condition affecting roughly one in eight adults may carry a psychiatric burden far deeper than…
Studies
US Safety-Net Programs Linked to Higher ED Use, Not Better Child Health
For families navigating poverty, the assumption that enrolling in federal assistance programs automatically translates…
Studies
THC/CBD Combination Reduces Severe RLS Symptoms in 12-Week Trial
Restless legs syndrome remains one of the most undertreated neurological conditions, partly because the long-favored…
Fitness
Untreated Sleep Disorders Measurably Impair Athletic Recovery and Peak Performance
Sleep is increasingly recognized not as passive downtime but as an active physiological process that directly governs…
Studies
Fentanyl Purity Drop May Not Explain 2023 Overdose Decline, Study Finds
Understanding why opioid overdose deaths began falling after reaching historic peaks matters enormously for public…
Supplements
Semaglutide Cuts Weight 22% But Raises Erectile Dysfunction Risk 4.5-Fold
A systematic PubMed review (2020–2026) maps the urological and andrological footprint of GLP-1 receptor agonists…
Supplements
Coumarin Compound Scoparone Targets miRNA-AMPK Pathway to Reverse Fatty Liver
Fatty liver disease has quietly become one of the most prevalent metabolic disorders worldwide, yet effective…
Studies
Neutrophil Extracellular Traps Emerge as Liver Disease Therapeutic Target
Chronic and acute liver diseases remain among the most undertreated conditions in modern medicine, partly because the…
PREPRINTNutrition
Three Thiamine Measures Diverge: TDP, Diet, and Enzyme Function Tell Different Stories
A pilot study measuring thiamine diphosphate (TDP), erythrocyte transketolase activity (TKT), and activity…
Longevity
GLP-1 Therapies Show Promise for Women's Cardiometabolic Risk, But Sex-Specific Data Remain Scarce
Women's cardiometabolic risk from obesity follows distinct hormonal trajectories—from menarche through menopause—that…
Studies
SARM1 Axon-Degeneration Enzyme Not Directly Activated by Double-Stranded DNA
Understanding what switches on the axon self-destruction program matters enormously for conditions ranging from…
Supplements
Gut Bacterium's Anti-Inflammatory Power Traced to Single Metabolite
Understanding why the same probiotic species produces dramatically different health outcomes across individuals has…
Studies
GLP-1 Drugs Alter Surgical Risk: Individualized Perioperative Protocols Now Recommended
As millions of patients on semaglutide, tirzepatide, and related agents enter operating rooms worldwide…
Studies
High-Dose Vitamin D3 in Pregnancy Tested Against Preterm Birth in RCT
Preterm birth remains one of the most consequential complications of pregnancy, particularly in South Asia where…
Studies
Gliomas Hijack Creatine Metabolism to Electrically Stimulate Their Own Growth
Brain cancer's relationship with the neurons it inhabits has long been suspected as a driver of malignancy, but the…
Studies
mNGS Detects TB and NTM With Near-Perfect Accuracy When Cultures Fail
When conventional microbiology goes silent, clinicians face a dangerous diagnostic gap: tuberculosis and…
Studies
NaV1.8 Inhibitor Suzetrigine Matches Opioid Analgesia Without Addiction Risk
The opioid crisis has forced medicine into an uncomfortable compromise: accept addiction risk or accept inadequate…
Studies
CYP450 Enzyme Dysregulation Links Vitamin D and Cholesterol to Neurodevelopmental Disorders
For families and clinicians navigating autism spectrum disorder, Rett syndrome, or ADHD, the biological underpinnings…
Nutrition
Ancestral-Pattern Diet in Pregnancy Measurably Expands Fetal Subcortical Brain Structures
Fetal brain development may be more directly shaped by maternal diet quality than previously appreciated — and a…
Studies
Preterm Gut Dysbiosis Drives Multi-Organ Disease via Microbiome-Immune Axes
The microbial ecology established in the first weeks of life may be among the most consequential determinants of…
Studies
Phase III Trial Finds High-Dose IV Vitamin C Fails Severe Burn Patients
Intravenous vitamin C has attracted significant clinical interest as a low-cost, seemingly safe intervention capable…
Studies
Phase III Trial: High-Dose IV Vitamin C Fails Burns, May Raise Mortality
For years, intravenous vitamin C has been administered to severe burn patients based on the premise that its…
Longevity
Liver-Muscle Lactate Failure Identified as Core Driver of Age-Related Muscle Loss
Muscle wasting in aging has long resisted a unified mechanistic explanation, leaving clinicians without a clear…
Supplements
Resveratrol Disrupts Klebsiella Quorum Sensing, Cuts Dual-Species Biofilm by 55%
Resveratrol, quercetin, and epigallocatechin gallate (EGCG) were computationally screened against LuxS — a key enzyme…
Studies
Circulating Tumor DNA Liquid Biopsies Reshape Cancer Monitoring and Treatment Guidance
For anyone touched by cancer — as a patient, caregiver, or clinician — the promise of a simple blood draw replacing or…
Studies
PCOS-Linked Estrogen Pathways Raise Endometrial Cancer Risk in Premenopausal Women
Endometrial cancer is often framed as a postmenopausal disease, yet a growing body of evidence suggests that…
Studies
FDA Clears First Dual-Mechanism OTC Analgesic Combining Acetaminophen and Naproxen
For the roughly 50 million Americans managing chronic or acute pain daily, the arrival of a single pill that targets…
Longevity
Newly Identified PTCHD4 Protein Drives Cellular Senescence Via AKT Signaling
Understanding which molecular switches accelerate biological aging has become one of the most consequential questions…
Studies
PSMA-PET Imaging Reframes PSA Persistence as Stage Marker, Not Prognosis Driver
For men who undergo radical prostatectomy, a detectable PSA level that never fully clears has long been treated as an…
Studies
Lumateperone Adjunct Significantly Improves Sexual Function in Treatment-Resistant Depression
Sexual dysfunction is one of the most underreported yet treatment-limiting side effects in antidepressant therapy…
Nutrition
Gut Microbiome Composition Predicts and Shapes Immunotherapy Outcomes in Solid Tumors
For cancer patients receiving immunotherapy, why some respond dramatically while others barely at all has long been…