AF Linked to Brain Changes Independently of Stroke: Large UK Biobank MRI Study with Mendelian Randomization Support
Across 502,099 UK Biobank participants, atrial fibrillation (AF) independently associated with reduced global grey…
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Across 502,099 UK Biobank participants, atrial fibrillation (AF) independently associated with reduced global grey…
GLP-1 receptor agonists (GLP-1RAs) — originally developed for type 2 diabetes and now dominant obesity pharmacotherapy…
A proprietary crystalline salt form of nicotinamide riboside — NR fumarate, branded Restorin NR — achieved blood NAD+…
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
The EVOKE and EVOKE+ trials delivered a sobering verdict: oral semaglutide failed to slow clinical progression in…
Understanding why semaglutide and similar drugs produce such dramatic, sustained weight loss has been one of the…
The conventional focus on adult dietary habits may be missing a far more consequential window: the first years of…
Precision medicine's promise of personalized treatment hinges on identifying who actually responds differently to…
For decades, the boundary between beneficial and potentially harmful microorganisms in the food supply has remained…
When two marginalized identities converge in a healthcare setting, the resulting disadvantage is rarely simply…
Decades of neuroscience textbooks may need updating. The long-held assumption that the striatum communicates with the…
Understanding why the Down syndrome brain develops with fewer neurons and excess glial cells has been one of…
For the millions of adults incidentally discovered to have thyroid nodules — a finding increasingly common as neck…
For decades, the search for Alzheimer's disease prevention has centered on drugs targeting amyloid-beta plaques — yet…
The expanding clinical interest in GLP-1 receptor agonists — already reshaping obesity and diabetes care — has long…
For the millions living with Parkinson's disease, deep brain stimulation already transforms daily life — but its…
Chronic mTOR hyperactivation drives ovarian aging through suppressed autophagy, mitochondrial dysfunction, impaired…
Brain inflammation survivors are rarely counseled about their elevated long-term cognitive risk — yet the trajectory…
For women who experience menopause before age 45, the biological clock is already working against them — but new…
Diabetic cardiomyopathy remains one of the most underappreciated contributors to cardiovascular mortality in people…
For the estimated 500 million people living with osteoarthritis worldwide, the absence of any approved therapy capable…
Early detection of oral cancer could dramatically shift survival outcomes — yet the mouth remains one of the harder…
Cognitive health across adulthood may depend less on how fast the brain ages overall and more on where it ages fastest…
For anyone tracking biological age through DNA methylation tests, this research delivers an important reality check…
For decades, poor sleep was catalogued alongside fatigue and malaise — a downstream consequence of being sick rather…
A protocol paper describes ASHA Assist India, a cloud-based AI mobile health platform designed to integrate stroke…
The assumption that microglial activity in Alzheimer's disease is either harmful or protective may be fundamentally…
Cognitive decline remains one of the most feared consequences of aging, yet pharmacological options for prevention…
Mental health in competitive sport is often eclipsed by physical performance metrics, yet the psychological burden on…
For the millions still grappling with persistent cognitive dysfunction months or years after acute COVID-19 infection…
Chronic airway inflammation has long been suspected as a biological bridge between asthma and lung cancer, but…
For the roughly three million agricultural workers toiling outdoors across American fields, climate change is not an…
As mental health care faces a global access crisis, millions are quietly turning to general-purpose AI tools for…
Substance use disorders remain one of the most persistent and undertreated health disparities facing American Indian…
When scarce public health dollars are allocated poorly, the cost is measured not just in money but in lives — and for…
For the roughly 50 million people living with dementia worldwide — and the larger population at risk — the pace of…
Smoking rates among people living with schizophrenia, bipolar disorder, and major depressive disorder remain two to…
Detecting Huntington's disease before symptoms appear has long been a clinical priority, given that neurodegeneration…
Sudden unexpected infant death remains one of the most devastating outcomes in early childhood medicine, and a…
Amid persistent gaps in maternity care quality across the developing world, a deceptively simple intervention — having…
For anyone living with or at risk of multiple sclerosis, the precision of the initial diagnostic scan can determine…
For decades, Alzheimer's research has treated amyloid plaques and tau tangles as inevitable harbingers of cognitive…
Hemorrhagic transformation after late-window thrombolysis remains one of the most feared complications in acute…
For decades, Alzheimer's disease was diagnosed primarily through cognitive decline — meaning intervention came only…
The idea that adult depression can be partially shaped by events occurring in the first days of life challenges a…
Multiple sclerosis affects nearly 2.9 million people worldwide, yet its relapsing-remitting cycles remain poorly…
For decades, cardiovascular exercise dominated longevity conversations, but mounting evidence is repositioning…
Anyone who has ever slept poorly in an unfamiliar environment—a hotel, a sleep lab, a friend's guest room—has…
For the millions of adults undergoing noncardiac surgery each year, cardiac complications represent one of the most…
Pancreatic ductal adenocarcinoma remains one of oncology's most intractable challenges precisely because KRAS…
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
In a prospective cohort of 400 Black adolescents from lower-income Chicago households, exposure to neighborhood gun…
Analyzing 6,676 participants from the Guangdong Gut Microbiome Project, this cross-sectional study identified 222 OTUs…
Chronic low-grade inflammation — inflammaging — has long been recognized as a root driver of age-related disease, but…
For the roughly 39 million people living with HIV globally, viral suppression via antiretroviral therapy is no longer…
Cerebral palsy, cognitive impairment, and sensory disabilities remain among the most consequential outcomes of…
For the millions of men who undergo prostate cancer surgery each year, a rising PSA after the procedure—known as…
Understanding which brain regions drive emotional experience — and being able to decode those states reliably from…
As multicancer early detection tests move from laboratory promise toward population-scale deployment, a critical…
Most adults track their health by counting steps or logging gym sessions — but the biological measure of how…
A conceptual framework from Heilongjiang University positions metainflammation — chronic low-grade inflammation…
As anti-amyloid therapy moves from clinical trials into everyday medical practice, the gap between controlled trial…
Liver fibrosis affects hundreds of millions of people globally and currently lacks approved pharmacological treatments…
Ischemic stroke remains one of the leading causes of death and long-term disability worldwide, yet the therapeutic…
The blood system is quietly central to how we age. Hematopoietic stem cells (HSCs) orchestrate lifelong immune…
When a hemorrhagic fever with no approved treatments and case fatality rates historically exceeding 80% strikes an…
Among 869 older adults (mean age 70.7) in the Baltimore Longitudinal Study of Aging, both subjective insomnia symptoms…
The relationship between early childhood experience and long-term psychological resilience is one of the most…
Analyzing 2,442,939 Austrians aged 65+ across 2014–2023, this nationwide retrospective cohort study identified 4,724…
Among 5,152 U.S. adults tracked from 2021–2023 in the CHASING COVID Cohort, being sedentary combined with…
Industrial fires represent a largely invisible gap in environmental health research, even as communities living near…
A protein woven into the brain's structural scaffolding may play a more active role in cognition than previously…
As cannabis legalization expands across multiple continents, understanding its cognitive costs — particularly for…
Among 16 families managing inherited cardiovascular disease at Stanford Health Care, 81.2% expressed support for…
In a within-subjects experiment with 128 adults aged 65+ (mean age 71.5, 70% female), simpler instructions lacking…
Four decades of psychoneuroimmunology research from Kiecolt-Glaser's lab at Ohio State establishes a robust causal…
Understanding why a single psychedelic session can produce psychiatric benefits lasting weeks or months has been one…
Understanding precisely why psychedelic compounds alter consciousness so profoundly—and why those alterations…
For anyone tracking the molecular roots of Parkinson's disease, understanding exactly how protein clumps form in…
The aging of the HIV-positive population is quietly reshaping one of the most complex intersections in American…