PREPRINTSupplements
Lab4 Probiotic Cuts GP Visits by 52% in Healthcare Workers—But Trial Too Small
In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently…
Studies
Breaking results from peer-reviewed journals, clinical trials, and medical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTNutrition
Diet-as-Medicine App Cuts Blood Pressure 5.5 mmHg After Correcting Statistical Bias
A retrospective cohort study of 329 US adults with obesity enrolled in a commercial digital food-as-medicine program…
PREPRINTLongevity
Four Inflammatory Markers Explain 57% of Black-White Heart Failure Gap
In a 16-year prospective follow-up of 6,785 multi-ethnic adults (MESA cohort, 2000–2002), four baseline biomarkers…
PREPRINTNutrition
DASH Diet Adherence Among Hypertensive US Adults Dropped 16% by 2018
Among 14,163 US adults with self-reported hypertension drawn from NHANES cycles 2003–2018, adherence to the DASH diet…
PREPRINTWellbeing
Temperature-Regulated Sleep Surface Adds 33 Minutes of Sleep in Most Sleep-Deprived Adults
Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep…
Longevity
Atorvastatin 40mg Cuts CV Events 30% in Over-70s But Misses Disability-Free Survival
In the STAREE trial — a double-blind, randomized, placebo-controlled study of 9,971 community-dwelling Australians…
Longevity
Weak Grip + Underweight Quintuples Premature Death Risk in 200K Adults
In a prospective analysis of 200,405 UK Biobank participants aged 60 and older (median follow-up ~14.5 years)…
Longevity
In-hospital Statins Cut Mortality 49% in Adults Over 75
Among 545 patients aged 75 or older admitted to an acute geriatric ward, receiving statin therapy on day 2 of…
Fitness
Unstructured Daily Movement Cuts Depression and Blood Pressure in 8,551 Adults
Across 38 randomized controlled trials enrolling 8,551 adults, interventions that wove physical activity into daily…
Studies
MASLD + High Lp(a) Doubles Cardiovascular Risk in Multi-Ethnic Cohort
In a secondary analysis of the Multi-Ethnic Study of Atherosclerosis (MESA), adults with metabolic…
Supplements
Vitamin D Supplements Show Little Bone Benefit in Non-White Adults Across 8,000-Person Review
A systematic review and meta-analysis of 12 randomised controlled trials encompassing 8,023 adults from Black African…
Fitness
Resistance Training After Weight Loss Prevents T2D Risk Rebound at 1 Year
Among 221 sedentary women with overweight (mean BMI 28.3), an 800 kcal/day diet drove BMI to 23.9, slashing predicted…
Supplements
Oral Semaglutide Cuts Body Weight 10.5% in 28 Weeks, Shrinks Liver Fat
In a 28-week randomized controlled trial of 116 non-diabetic adults with obesity or overweight plus comorbidities…
Nutrition
Dietitian-Led Nutrition Beats Standard Advice for Cirrhosis Sarcopenia: RCT
In a 180-patient randomised controlled trial of decompensated cirrhosis with sarcopenia, six months of…
Longevity
18-Month Exercise-Nutrition Program Slows Cognitive Decline in Targeted Older Adults
An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant…
Studies
Bariatric Surgery Neurological Risk: 1.4–16% Incidence, Thiamine Deficiency Dominates
Across 12 studies encompassing more than 5,000 bariatric surgery patients, neurological complication rates ranged from…
Nutrition
Dietetic Counseling Cuts Systolic BP 5–7 mmHg; Wearables Add Modest Pulse Pressure Benefit
In a 954-person, three-arm RCT of adults aged ≥55 with metabolic syndrome risk factors, all intervention groups…
Fitness
151 Genes Linked to Muscle Strength Preservation During 2-Year Calorie Restriction
A secondary transcriptomic analysis of the landmark CALERIE randomized controlled trial — a 2-year caloric restriction…
Fitness
12-Week RT+HIIT Shows Minimal Transcriptomic Gains; Polyphenols Add Nothing
A 12-week supervised concurrent resistance training plus HIIT programme in 38 adults aged 55–70 years produced…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
Fitness
Training at Peak vs. Trough Time of Day Makes No Difference for Older Adults
A 12-week randomized controlled trial in 93 adults (mean age 67) found that matching resistance training to an…
Wellbeing
Healthy Sleep Cuts Stroke Risk 14% Via Lipid and Inflammation Pathways
In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component…
Wellbeing
Social Isolation After Stroke Raises CVD Death Risk 57%, Loneliness Doubles Dementia
Among 7,267 stroke survivors in the UK Biobank followed for a median 10.2 years, social isolation independently raised…
Studies
Weekly Dual GIP/Glucagon Agonist Cuts Weight Significantly in Obese Diabetics
The convergence of obesity and type 2 diabetes represents one of the most consequential metabolic challenges in modern…
Studies
Semaglutide Shows Measurable Kidney-Protective Mechanisms in Diabetic Patients
Chronic kidney disease is the leading cause of end-stage renal failure in adults with type 2 diabetes, and slowing its…
PREPRINTWellbeing
Sleep Hypoxic Burden Outperforms AHI for Heart Failure Prognosis Over 3.7 Years
Among 178 heart failure patients not receiving airway pressure therapy — followed for a median 3.7 years after acute…
PREPRINTLongevity
Frequent High-NO2 Days Accelerate 14-Year Cognitive Decline in Older Adults
Among 12,235 English adults aged 50 and older followed for up to 14 years in the English Longitudinal Study of Ageing…
PREPRINTLongevity
Meeting BP, LDL, and A1c Targets Still Leaves 2–4× CV Risk Gap by Social Context
Among adults in the All of Us cohort who already met standard cardiovascular prevention targets — systolic BP below…
PREPRINTWellbeing
Repeated Partner-Inflicted Head Injuries Age Women's Brains by Up to 28 Years
Among 207 women with lifetime exposure to physical intimate partner violence, those reporting ten or more…
PREPRINTLongevity
HDL Cholesterol Shows J- and U-Shaped Mortality Curves in 150,000 Adults
In 47,123 Mexican men and 97,589 women followed prospectively, HDL cholesterol showed non-linear associations with…
Nutrition
Personalized Dietary Plans Beat Usual Care for MASLD Weight Loss by 6.7 kg
Across 14 randomized controlled trials enrolling 1,805 adults with metabolic dysfunction-associated steatotic liver…
Nutrition
Heart-Healthy Diet Cuts Fatty Liver Odds by 84% in Iranian Adults
In a case-control study of 675 Iranian adults (225 NAFLD cases, 450 controls), those scoring in the highest tertile of…
Studies
Lean MASLD Carries Similar Long-Term Mortality Risk as Obese MASLD
In a multinational retrospective study of 18,326 biopsy-confirmed MASLD patients across 41 countries, lean individuals…
Wellbeing
Smoking After Heart Attack Doubles Mortality Risk vs. Quitters
Among 65,990 Spanish adults tracked across three national health surveys (2011–2017) and linked to mortality data…
Studies
Triple Hormone Agonist Retatrutide Drives Substantial Weight Loss in Phase III Trial
Obesity pharmacotherapy is entering a new era, and the latest data suggest the ceiling on drug-induced weight loss may…
PREPRINTNutrition
Erythritol and Xylitol Show No Platelet-Activating Effect in Crossover Trial
A randomized, single-blind crossover trial in 14 healthy adults tested whether acute oral doses of erythritol (50 g)…
PREPRINTStudies
CGM-Detected Glucose Spikes Raise Liver Scarring Risk 28–59% in Non-Diabetics
In 1,071 adults from the Framingham Heart Study Third Generation cohort (mean age 60.2, BMI 28.2, 56% normoglycemic)…
PREPRINTFitness
Daily Air Pollution Spikes Cut Next-Day Steps by 483 in Adults Over 50
In a micro-longitudinal study of 67 UK adults aged 50–85, days with higher-than-usual personal PM2.5 exposure — just…
Nutrition
CBT-Enhanced Liver Program Cuts Cardiovascular Events 64% in Fatty Liver Disease
A randomized controlled trial of 286 adults with metabolic dysfunction-associated steatotic liver disease (MASLD)…
Studies
SGLT2 Inhibitors Show No Clear Anti-Inflammatory Effect Across 47 Trials
Pooling 47 randomized controlled trials, SGLT2 inhibitor therapy produced no statistically significant reductions in…
Nutrition
Gut Butyrate Producers Determine Whether Protein Aids Post-Stroke Recovery
In 152 older stroke patients (mean age 78.4 years) undergoing inpatient rehabilitation, the benefit of dietary protein…
Studies
Endogenous Oestradiol Levels Don't Predict Heart Risk or Death in Women 70+
In 5,535 women aged 70 or older enrolled in the Sex Hormones in Older Women (SHOW) Study — a sub-study of the ASPREE…
Studies
Oral GLP-1 Pill Cuts HbA1c 1.45% in Drug-Naive Type 2 Diabetes
Injectable GLP-1 receptor agonists have transformed metabolic medicine, but needle aversion and cold-chain logistics…
PREPRINTWellbeing
Social Isolation Raises Death Risk 34%; Transport Mode Modifies the Harm
In a UK Biobank cohort of 490,114 adults aged 40–69, followed from 2006 to 2022, social isolation was associated with…
PREPRINTLongevity
Night Shift Work Raises CVD Risk 7% Per 5 Years; Morning Types Hit Hardest
Among 69,458 female nurses followed from 2009 to 2021 in the Nurses' Health Study II, each additional 5 years of…
PREPRINTWellbeing
Marijuana Cuts HRV by 0.47ms and Fragments Sleep Across 17,000 Wearable Users
Across 16,965 wearable-device users contributing over 5.2 million person-days of data, nightly marijuana use was…
PREPRINTNutrition
Oat Milk Delivers Far Fewer Amino Acids Than Dairy, Even With Added Pea Protein
In a randomized crossover trial, 12 healthy men consumed 750 ml of semi-skimmed dairy milk, a standard oat-based drink…
PREPRINTWellbeing
Four Sleep Dimensions Tied to Cognitive Function in Adults 55+
In a Chicago-based observational study of 324 adults aged 55 and older (64% women, 37% Black, 14% Hispanic/Latino)…
Nutrition
KCl Tablets Cut Systolic BP ~8 mmHg by Flushing Hidden Tissue Sodium
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
Studies
OAGB Cuts Long-Term Weight Regain Risk 66% vs Sleeve Gastrectomy
Across 1,498 adults followed for a median of 53–66 months after bariatric surgery, all three procedures achieved…
Studies
GLP-1 + SGLT2i Combo Cuts CKD Mortality 45% vs Monotherapy
In a propensity-matched real-world cohort of 32,448 adults with chronic kidney disease, adding a GLP-1 receptor…
PREPRINTFitness
Five Proteins Predict Which Heart Failure Patients Gain Most from Exercise Rehab
In 243 older adults (≥60 years) hospitalized for heart failure and enrolled in the REHAB-HF trial, pre-intervention…
PREPRINTSupplements
Phosphatidylserine 300mg/day Misses Primary Memory Target but Hints at Working Memory Gains
A 12-week randomized, double-blind, placebo-controlled trial in 70 adults aged 35–65 with subjective memory complaints…
PREPRINTNutrition
High Omega-3 Index Linked to 4.7-Year Younger Biological Age in 4,863 Adults
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…
PREPRINTWellbeing
Home PEMF Therapy Cuts Blood Pressure by >1 Clinically Meaningful Unit in Small Meta-Analysis
A systematic review and meta-analysis of 10 randomised trials (353 participants) found that pulsed electromagnetic…
PREPRINTSupplements
Tirzepatide Cuts New Heart Failure Risk 10%, Mortality 20% vs Semaglutide in Obesity
In a propensity-score-matched retrospective cohort of 848,538 adults with obesity drawn from the TriNetX platform…
Wellbeing
Each Year After Quitting Smoking Cuts Fracture Risk ~1% in Older Women
In a prospective cohort of 3,024 Swedish women aged 75–80, current smokers faced a 35% higher risk of any fracture (HR…
Longevity
Statins Cut All-Cause Mortality 20% in Older Cancer Survivors With Heart Disease
Among 2,714 U.S. cancer survivors aged 65+ drawn from ten NHANES cycles (1999–2018), statin use was independently…
Nutrition
Soy Diet Cuts Hot Flash Frequency But Evidence Remains Very Low Certainty
Across 15 randomized controlled trials enrolling 1,952 women aged 40–65, soy-based dietary interventions produced a…
Nutrition
Mediterranean Diet Cuts Ferritin 22 ng/mL in Metabolic Syndrome Over 32 Weeks
A 32-week, 30%-energy-deficit Mediterranean-style intervention in 190 overweight adults revealed that ferritin…
Nutrition
Low Fish, Legumes, and Fruit Intake Linked to 4-6x Higher MASLD Odds
In a case-control study of 111 adults attending a diet clinic in Turkey, consuming less than one fish serving per week…
Nutrition
8-Month Nutrition Education Cuts Cholesterol, BMI in Family Farmers
An 8-month nutrition education intervention across 7 structured sessions improved diet quality scores in 81 Brazilian…
Nutrition
Diet Drives 40% of Colorectal Cancer Deaths; Burden Rising to 2030
Analysis of Global Burden of Disease 2023 data across G20 nations spanning 1990–2023 finds that dietary risks account…
Studies
Fracture-Prevention Drugs in Men: Cochrane Review Finds Thin Evidence
A Cochrane systematic review pooled 17 randomised controlled trials enrolling 4,132 men aged 50–73 to evaluate…
Studies
GLP-1/SGLT-2 Drugs Cut Kidney Failure Risk 40% — But Only With Albuminuria
In a target trial emulation drawing on 75,455 adults with type 2 diabetes across 12 U.S. health systems, GLP-1…
Fitness
Cardiorespiratory Exercise After Stroke: 53-Trial Cochrane Meta-Analysis
A Cochrane systematic review and meta-analysis of 53 randomised controlled trials (2,672 participants, mean age 61.9…
Longevity
High Uric Acid Triples Mortality Risk in Older Women: Cohort Data
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
Fitness
Each 1 mL/kg/min Higher VO2peak Cuts Cardiac Event Risk 7% in Men
In 1,651 Norwegian coronary artery disease patients (21% women, mean age 61) followed across 7,880 person-years of…
Nutrition
70% Plant Protein Diet Cuts TMAO by 4.6 μg/mL in Advanced CKD Patients
In a 4-week randomized controlled trial of 36 Japanese patients with severely impaired kidney function (median eGFR 13…
Supplements
Probiotic Converts Citrus Compound to Activate Longevity Gene, Reversing Age-Related Metabolic Decline
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Fitness
26 Trials: Exercise Boosts Upper-Limb Bone Density in Women by Large Margin
Across 26 controlled trials involving 1,880 women, exercise produced a large pooled effect on upper-limb bone outcomes…
Nutrition
Peanut-Induced Lipidome Shifts Cut Type-2 Diabetes Risk 11%, BMI Mediates 89%
A peanut-derived plasma lipidomic signature (PeLS), constructed by combining lipid changes observed in a 6-month…
Fitness
227 RCTs: Exercise Alone Beats Multidomain Programs for Older Brain Health
A pre-registered systematic review and network meta-analysis of 227 randomised controlled trials compared…
Fitness
Structured Exercise Cuts Cancer Mortality Risk by 18–26% in RCT Meta-Analysis
Across 21 randomised controlled trials encompassing up to 5,492 cancer patients, structured exercise interventions…
Nutrition
Nordic Diet Cuts 24-Year Mortality Risk by 2.67% But Misses Liver Disease
Across two Swedish population-based cohorts totalling 64,406 middle-aged and older adults, adherence to a Healthy…
Fitness
Telerehabilitation Boosts VO₂ Peak by 2.58 mL/kg/min in Heart Disease Patients
Across 13 randomized controlled trials enrolling 958 adults with cardiovascular disease, exercise-focused…
Fitness
Each 1-MET Fitness Gain Cuts Cardiometabolic Multimorbidity Risk by 19%
Among 5,255 Chinese adults aged 45+ followed for nine years, each 1-MET increment in estimated cardiorespiratory…
Nutrition
Higher Body Fat Drives Emotional Eating — Not the Reverse
In the Fenland cohort — a prospective UK study of middle-aged adults born 1950–1975 — higher baseline BMI and…
Fitness
Persistent Grip Asymmetry Raises Death Risk 32%; Low Strength Doubles It
Across 8,924 Chinese adults aged 45+ followed for a median of 5.4 years, two distinct grip-strength markers predicted…