PREPRINTLongevity
42% Speed Drop at Home: Shorter Steps Expose Hidden Mobility Gap in 3,424 Seniors
Wearable inertial sensors tracking 3,424 older adults reveal a dramatic 0.41 m/s difference between clinical corridor…
Longevity
Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTLongevity
AF Linked to Brain Changes Independently of Stroke: Large UK Biobank MRI Study with Mendelian Randomization Support
Across 502,099 UK Biobank participants, atrial fibrillation (AF) independently associated with reduced global grey…
PREPRINTNutrition
8 Proteins Map Healthy Plant-Based Diets to Lower Cancer and CVD Risk
Analyzing 7,285 circulating protein aptamers in 4,372 EPIC cohort participants, researchers identified specific…
PREPRINTLongevity
AI Model Reads Coronary Angiograms With 0.94 AUROC, Rivals Expert Cardiologists
Trained on 135,475 coronary angiography examinations comprising 812,850 multi-view videos from two Shanghai hospitals…
Longevity
Oral Semaglutide Failed Symptomatic Alzheimer's Trials Despite Biomarker Gains
The EVOKE and EVOKE+ trials delivered a sobering verdict: oral semaglutide failed to slow clinical progression in…
Longevity
Single-Subject DELTA Protocol Integrates TRE, Mediterranean Diet, and AI Biomarkers for Healthspan
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
Studies
FGF23 Mutation Mechanisms Reveal New Targets for Phosphate Disease Treatment
Phosphate metabolism rarely makes headlines, yet its dysregulation underlies some of the most debilitating bone and…
Studies
Small-Molecule AT1R Agonist Challenges Decades of Cardiovascular Drug Design
For decades, the pharmacological playbook for the angiotensin II type 1 receptor has been written in one direction…
Longevity
Gut Cells Sense Food Quantity Via Cytoplasmic Fluidity to Control Cell Fate
How intestinal cells decide whether to renew, differentiate, or die has long been framed around molecular signals…
Nutrition
Early Sugar Restriction Cuts Adult Cancer Risk via Slowed Biological Aging
The conventional focus on adult dietary habits may be missing a far more consequential window: the first years of…
Studies
CRISPR Screen Identifies Four Gene Knockouts That Boost CAR-T Persistence in Solid Tumors
The stubborn failure of CAR-T cell therapies against solid tumors — in contrast to their success in blood cancers…
Studies
CIP2A–TOPBP1 Complex Found to Govern DNA Break Repair During Cell Division
Maintaining genomic integrity during cell division is one of the most demanding tasks biology faces — and failures…
Longevity
3D Whole-Ovary AI Mapping Uncovers Organ-Wide Control of Oocyte Depletion
Understanding exactly how the ovarian reserve depletes over time has direct implications for predicting reproductive…
Studies
Four-Gene Signature Links Single-Cell Sequencing to Pancreatic Cancer Metastasis Risk
Pancreatic ductal adenocarcinoma remains one of oncology's most lethal diagnoses precisely because liver metastasis…
Studies
Germline Cancer Syndromes Yield New Prevention Targets Beyond Early Detection
For the roughly 10% of cancer patients harboring inherited germline mutations, prevention has long meant surveillance…
Studies
Cannabis-Tobacco Co-Use Linked to Greater Respiratory Harm Than Cannabis Alone
As cannabis legalization spreads and consumption norms shift, understanding which delivery methods carry the greatest…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB and HIV Co-Infection Trends 1990–2023
Tuberculosis remains one of the most consequential infectious diseases in human history, yet its burden is unevenly…
Studies
Late-Life Hormone Therapy Linked to Mixed Cancer and Cardiovascular Outcomes in Large Cohort
For millions of postmenopausal women managing chronic symptoms well into their sixties and beyond, the question of…
Longevity
Hyperfunction Theory Reframes Aging as Programmatic Overdrive, Not Damage Accumulation
Most people assume the body simply wears out — accumulating molecular errors until systems fail. A compelling…
Studies
Two-Thirds of US Women Enter Pregnancy With Preventable Risk Factors
Most conversations about prenatal health focus on the nine months of pregnancy, yet the biological groundwork for…
Studies
NP-Led Thyroid Nodule Clinic Cuts Diagnostic Wait Time by 84 Days
For the millions of adults incidentally discovered to have thyroid nodules — a finding increasingly common as neck…
Fitness
Aerobic Exercise Activates Brain's Waste-Clearance System Via Multiple Mechanisms
For decades, the search for Alzheimer's disease prevention has centered on drugs targeting amyloid-beta plaques — yet…
Studies
GLP-1 Receptor Circuit in Septum Found to Gate Alcohol Reward in Mice
The expanding clinical interest in GLP-1 receptor agonists — already reshaping obesity and diabetes care — has long…
Longevity
GLP-1 Weight Loss Beyond 20% Associated with Skin Sagging in 72% of Patients
Among 1,226 patients enrolled in a virtual cardio-kidney-metabolic program, dermatologic side effects of GLP-1…
Longevity
Senescence Escape vs. Persistence: A Fate-Resolved Framework Reframes Anti-Aging Targets
A conceptual framework published in Ageing Research Reviews dismantles a persistent conflation in senescence biology…
Supplements
C15:0 Fatty Acid Docks mTOR at -4.4 kcal/mol, Suggesting Fertility-Safe Rapamycin Alternative
Chronic mTOR hyperactivation drives ovarian aging through suppressed autophagy, mitochondrial dysfunction, impaired…
Longevity
RSV Vaccine Uptake Gap in Older Adults Undermines Healthy Aging Goals
For older adults, maintaining independence and avoiding hospitalization are defining health priorities — yet a highly…
Longevity
Unfavorable Social Conditions Amplify Mortality Risk 75% in Early Menopause
For women who experience menopause before age 45, the biological clock is already working against them — but new…
Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Body Weight in Phase 3 Trial
For people managing type 2 diabetes without medication, a triple-action hormone receptor agonist may represent a…
Studies
TCR-Mimic Bispecific Antibody Shrinks HIV Reservoirs and Delays Viral Rebound
The most stubborn obstacle to an HIV cure is not the circulating virus — antiretroviral therapy handles that — but the…
Studies
Embryonic Gene SIX1 Proves Essential for Lifelong Adult Hearing Maintenance
The conventional assumption that developmental genes simply switch off after embryonic tissue formation has long…
Studies
Structural Map of Non-Canonical Inflammasome Reveals Dynamic Heterogeneity
Understanding how the body's inflammatory machinery assembles at the molecular level could eventually reshape how…
Longevity
Deep Learning Reveals Region-Specific Brain Aging Patterns Tied to Cognitive Decline
Cognitive health across adulthood may depend less on how fast the brain ages overall and more on where it ages fastest…
Studies
Enteric Disease Deaths Drop 60% Globally Since 1990, Yet Gaps Persist
More than a million people still die from gut infections every year — and most of those deaths are preventable. This…
Longevity
Evolutionary Biology Offers New Framework for Why Menopause Persists in Humans
Menopause is one of biology's most puzzling paradoxes: why would natural selection preserve a trait that eliminates…
Studies
MASLD Replaces NAFLD: Two FDA-Approved Therapies Now Anchor Primary Care Protocol
Fatty liver disease has quietly become one of the most prevalent chronic liver conditions worldwide, yet it remains…
Studies
Dual-Target PD-1/VEGF Antibody Plus Chemo Yields Strong Early Response in Metastatic TNBC
Triple-negative breast cancer remains one of oncology's most stubborn challenges — lacking the hormone and HER2…
Longevity
Epigenetic Clocks Show High Lab Precision but Unstable Biological Readings
For anyone tracking biological age through DNA methylation tests, this research delivers an important reality check…
Studies
Cancer-Derived T Cell Engagers Emerge as Off-the-Shelf Autoimmune Therapy
For decades, autoimmune diseases like lupus, myasthenia gravis, and pemphigus have been managed rather than resolved…
Longevity
Ferroptosis Emerges as Unifying Iron-Death Mechanism Across Eight Cardiovascular Conditions
Iron-driven cell death may be quietly undermining heart and vascular health across a far wider spectrum of conditions…
PREPRINTLongevity
ATTR-CM Drugs Stabilize Heart Structure But Cannot Reverse Amyloid Damage
Across 18 studies encompassing 3,646 patients with transthyretin amyloid cardiomyopathy (ATTR-CM), disease-modifying…
PREPRINTNutrition
Food Marketing Associated with ~35 Extra kcal Intake in Children, TV Ads Linked to 44.5 kcal (Meta-Analysis)
Across 55 controlled studies enrolling 6,877 children and adolescents (ages 2–18), food and non-alcoholic beverage…
PREPRINTLongevity
Parental Epigenetic Score Predicts Offspring Artery Thickness 7 Years Later
A composite DNA methylation (DNAm) score derived from the American Heart Association's Life's Essential 8 (LE8)…
PREPRINTLongevity
26% 20-Year Mortality in 7,678 Adults with Congenital Heart Disease
A retrospective cohort of 7,678 adults with congenital heart disease (ACHD) followed at Mayo Clinic from 2002–2023…
Studies
2025 IDSA Guidelines Refine Antiviral Strategy for Mild COVID-19 Adults
Clinicians managing outpatient COVID-19 still face a genuinely complex decision landscape — not because effective…
Studies
Global CAD Imaging Study Reveals Wide Radiation Dose Variability Across Nations
Radiation exposure during cardiac imaging is an invisible but measurable risk that most patients never think to ask…
Studies
Liver Cancer Risk Diverges From BMI When Metabolic Injury Drives Hepatocarcinogenesis
The assumption that body weight reliably predicts cancer risk is increasingly strained — and nowhere more so than in…
Studies
Hip Fracture Risk, Recovery, and Prevention: What the Evidence Shows
For older adults and their families, few injuries carry higher stakes than a hip fracture — yet the gap between best…
Nutrition
Three Healthy Diet Patterns Associated With Reduced Dementia Risk in Older Adults With Alzheimer Pathology
Cognitive decline remains one of the most feared consequences of aging, yet pharmacological options for prevention…
Studies
Goal-Oriented Cognitive Rehab Outperforms Standard Care for Long COVID Brain Fog
For the millions still grappling with persistent cognitive dysfunction months or years after acute COVID-19 infection…
Studies
Four Major Cardiology Societies Align on Redefined Heart Failure Diagnostic Criteria
For the millions living with undiagnosed or misclassified cardiac dysfunction, a landmark consensus statement from the…
Studies
Three Genes Reveal Molecular Overlap Between Asthma and Lung Adenocarcinoma
Chronic airway inflammation has long been suspected as a biological bridge between asthma and lung cancer, but…
Wellbeing
Tau Research Consensus 2025: Biomarkers and Degradation Pathways Lead Therapeutic Advances
For the roughly 50 million people living with dementia worldwide — and the larger population at risk — the pace of…
Studies
Multimodal MRI With Motion-Resistant Mapping Detects Microstructural Changes in Pre-symptomatic Huntington's Carriers
Detecting Huntington's disease before symptoms appear has long been a clinical priority, given that neurodegeneration…
Studies
Vitamin B2 Metabolite FAD Acts as Dual Brake on Innate Immune Sensors
The idea that a core metabolic cofactor—one derived from dietary riboflavin and present in virtually every human…
Studies
France Updates MS Brain MRI Standards Around Two New Specificity Biomarkers
For anyone living with or at risk of multiple sclerosis, the precision of the initial diagnostic scan can determine…
Longevity
Microglial State Shifts at Amyloid-Tau Junction May Determine Dementia Fate
For decades, Alzheimer's research has treated amyloid plaques and tau tangles as inevitable harbingers of cognitive…
Studies
TB Deaths Fell Substantially Since 1990, But MDR-TB and HIV Gaps Widen (GBD 2023)
Three decades of progress against tuberculosis are real but dangerously incomplete — and recent collapses in global…
Studies
Fluid Biomarkers Reshape Alzheimer's Diagnosis Before Symptoms Appear
For decades, Alzheimer's disease was diagnosed primarily through cognitive decline — meaning intervention came only…
Longevity
CBFβ in Marrow Fat Cells Controls Stem Cell Aging via Senescence Axis
Core-binding factor β (Cbfβ) expression in bone marrow Adipoq+ cells (BMACs) — a specialized marrow adipocyte…
Longevity
Knee OA Reframed as Joint Aging: GAE and Senescence Targets Evaluated
A structured narrative review spanning PubMed/MEDLINE and Embase (2010–2026) positions knee osteoarthritis not as a…
Wellbeing
Early-Life Inflammation Primes Brain Immune Cells for Adult Depression via BAG3
The idea that adult depression can be partially shaped by events occurring in the first days of life challenges a…
Fitness
90–120 Minutes Weekly Resistance Training Linked to 13–27% Lower Mortality Risk
For decades, cardiovascular exercise dominated longevity conversations, but mounting evidence is repositioning…
Studies
2024 AHA/ACC Guidelines Reshape Perioperative Cardiac Risk Stratification Protocols
For the millions of adults undergoing noncardiac surgery each year, cardiac complications represent one of the most…
Longevity
TNFR1-Driven Inflammation Disrupts Fatty Acid Metabolism in Aging Gut Stem Cells
Gut health in older adults may be more tightly tied to systemic inflammation than previously understood — and a newly…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls Before 2035 Target
Tuberculosis remains one of humanity's most consequential infectious disease failures — a curable disease that still…
Nutrition
First-1000-Days Sugar Restriction Linked to 27–46% Lower Dementia Risk Decades Later
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
PREPRINTLongevity
Neighborhood Gun Violence Associated with 0.5% Lower Endothelial Function in Black Teens, with Diet and Adiposity as Mediators
In a prospective cohort of 400 Black adolescents from lower-income Chicago households, exposure to neighborhood gun…
Longevity
Smoking and Aging Share 85 Gut Microbiome Signatures Linked to ASCVD Risk
Analyzing 6,676 participants from the Guangdong Gut Microbiome Project, this cross-sectional study identified 222 OTUs…
Longevity
CSDH Mapped to Aging Hallmarks: Geroscience Framework Suggests Senolytic Research Targets
Chronic subdural hematoma (CSDH) — a blood collection beneath the skull's inner lining — is projected to become the…
Longevity
Fibrillarin-SIRT1 Axis Blocks Tumor Senescence via NAD+ Metabolism in ESCC
In esophageal squamous cell carcinoma (ESCC) patient cohorts, high intratumoral expression of fibrillarin (FBL), a…
Longevity
ACE2 Overexpression Protects Against Cardiac Aging Injury in K18-hACE2 Transgenic Mice
Most adults know ACE2 as the receptor SARS-CoV-2 exploits to enter cells, but this enzyme has a far older and more…
Longevity
Aging Stem Cells Hijack Immune Memory to Drive Chronic Inflammation via SIRT3 Loss
Chronic low-grade inflammation — inflammaging — has long been recognized as a root driver of age-related disease, but…
Studies
Hormone Therapy Benefit After Prostate Surgery Unchanged by Pathologic Risk Score
For men with recurrent prostate cancer after surgery, a persistent clinical question has been whether the severity of…
Studies
9-Gene cfDNA Methylation Classifier Distinguishes Malignant Pulmonary Nodules Noninvasively
Pulmonary nodules are among the most common incidental findings on chest imaging, yet determining whether they are…
Fitness
Smartphone JITAIs Show Early Promise Reducing Sedentary Time in Chronic Disease
For the estimated 60% of adults managing at least one chronic condition, the gap between knowing they should move more…
Longevity
Cardiorespiratory Fitness Outperforms Self-Reported Activity in Predicting Longevity
Most adults track their health by counting steps or logging gym sessions — but the biological measure of how…
Studies
CAC Zero Score Does Not Eliminate Risk When Lipoprotein(a) Is Elevated
For years, a coronary artery calcium score of zero has been used as a powerful reassurance tool — effectively a…
Longevity
QSP Model Identifies Two Distinct Drug Combos: Metabolic vs. Longevity Optimization
A quantitative systems pharmacology model integrating four mechanistic layers — metabolic/pharmacodynamic responses…
Longevity
Metainflammation Bridges Preclinical Obesity to CVD via 3 Interdependent Mechanisms
A conceptual framework from Heilongjiang University positions metainflammation — chronic low-grade inflammation…