Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep…
In a 16-year prospective follow-up of 6,785 multi-ethnic adults (MESA cohort, 2000–2002), four baseline biomarkers…
Among 14,163 US adults with self-reported hypertension drawn from NHANES cycles 2003–2018, adherence to the DASH diet…
In a prospective analysis of 200,405 UK Biobank participants aged 60 and older (median follow-up ~14.5 years)…
Among 221 sedentary women with overweight (mean BMI 28.3), an 800 kcal/day diet drove BMI to 23.9, slashing predicted…
In a 180-patient randomised controlled trial of decompensated cirrhosis with sarcopenia, six months of…
Across four major aging cohorts — HRS (USA), ELSA (UK), SHARE (Europe), and MHAS (Mexico) — adults who maintained…
Among 545 patients aged 75 or older admitted to an acute geriatric ward, receiving statin therapy on day 2 of…
In the STAREE trial — a double-blind, randomized, placebo-controlled study of 9,971 community-dwelling Australians…
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
In a 954-person, three-arm RCT of adults aged ≥55 with metabolic syndrome risk factors, all intervention groups…
An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant…
Among 12,235 English adults aged 50 and older followed for up to 14 years in the English Longitudinal Study of Ageing…
Among adults in the All of Us cohort who already met standard cardiovascular prevention targets — systolic BP below…
Among 207 women with lifetime exposure to physical intimate partner violence, those reporting ten or more…
In 47,123 Mexican men and 97,589 women followed prospectively, HDL cholesterol showed non-linear associations with…
Across 14 randomized controlled trials enrolling 1,805 adults with metabolic dysfunction-associated steatotic liver…
Across 16,884 adults from three longitudinal cohorts (ELSA, Whitehall II, and Rush MAP), difficulty falling asleep at…
In a randomized crossover trial, 12 healthy men consumed 750 ml of semi-skimmed dairy milk, a standard oat-based drink…
Across 16,965 wearable-device users contributing over 5.2 million person-days of data, nightly marijuana use was…
In a UK Biobank cohort of 490,114 adults aged 40–69, followed from 2006 to 2022, social isolation was associated with…
Among 69,458 female nurses followed from 2009 to 2021 in the Nurses' Health Study II, each additional 5 years of…
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…
In 243 older adults (≥60 years) hospitalized for heart failure and enrolled in the REHAB-HF trial, pre-intervention…
In a prospective analysis of 64,743 UK Biobank participants (mean age 61.5 years, 1,697 deaths), the sweet spot for…
A 32-week, 30%-energy-deficit Mediterranean-style intervention in 190 overweight adults revealed that ferritin…
Among 2,714 U.S. cancer survivors aged 65+ drawn from ten NHANES cycles (1999–2018), statin use was independently…
In Drosophila, genetic ablation of Lsp2 — a protein previously classified only as a larval storage protein but now…
Among 9,761 NHANES participants followed for a median of 7.42 years, 32.4% carried a diagnosis of metabolic…
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Across three major longitudinal cohorts totalling 40,520 middle-aged and older adults (CHARLS, ELSA, HRS), a composite…
Across 8,924 Chinese adults aged 45+ followed for a median of 5.4 years, two distinct grip-strength markers predicted…
A pre-registered systematic review and network meta-analysis of 227 randomised controlled trials compared…
In the 20-week MoKaRi randomized trial, adults with elevated LDL-C (≥3.0 mmol/L) not on lipid-lowering therapy who…
Four years of daily supplementation with vitamin D3 (2000 IU) and marine omega-3 fatty acids (1 g) produced no…
In a 12-week randomized non-inferiority trial of 108 adults averaging 66 years old, both a lacto-ovo vegetarian and an…
Among 2,380 adults who underwent metabolic and bariatric surgery (MBS) between 2008 and 2023, biological age…
Among 2,408 participants — 1,456 MRI-confirmed lacunar stroke cases and 952 hospital controls — Mendelian…
Pooling randomized controlled trials comparing ketogenic (KD) and Mediterranean diets (MD) head-to-head in adults…
Senescent osteocytes, mesenchymal stem cells, osteoblasts, immune cells, and vascular endothelial cells collectively…
Understanding how skin detects and responds to dry air has profound implications for conditions ranging from eczema…
Chronic pain management remains one of medicine's most stubborn challenges, with arthritis patients often cycling…
Understanding how mature, fully differentiated cells regulate gene expression in response to hormones has direct…
Understanding how immune cells remember past threats could reshape strategies for managing chronic inflammation…
Understanding how cells detect nutrient availability and adjust growth accordingly sits at the heart of aging biology…
Early cancer detection has long been the most promising — and most elusive — frontier in oncology. The difference…
Early cancer detection has long been the holy grail of oncology, yet most screening tools target single tumor types…
Tau pathology sits at the heart of Alzheimer's neurodegeneration, and the search for drugs that can interrupt its…
Among 77,758 propensity-matched patients with type 2 diabetes and heart failure with reduced ejection fraction…
Analyzing ultrarare damaging missense and predicted loss-of-function variants across five major biobanks—totaling more…
A preliminary head-to-head comparison tested whether paper-derived ECGs, digitized via ECGScan software, could…
A specific dietary amino acid ratio — 0.5% lysine combined with 0.5% arginine — reduces tumor burden and extends…
Repurposing existing drugs for cancer treatment has emerged as one of oncology's most pragmatic frontiers — bypassing…
For the millions of adults over 50 who undergo major elective surgery each year, the choice of anesthetic technique…
For older adults facing major surgery, the choice of anesthesia method has long been assumed to be largely…
For men diagnosed with localized prostate cancer, the central clinical challenge has never been simply eradicating the…
An 11% reduction in adolescent and young adult suicide deaths following the 988 Lifeline launch is a remarkable…
When a stroke trial changes its primary outcome midway through enrollment, the integrity of its central conclusion…
Heart disease remains the leading cause of death in adults over 65, yet most cardiology protocols were developed in…
For clinicians managing aging patients, vital signs and lab panels have long dominated routine assessments — yet one…
Early cancer detection has long been the holy grail of oncology — catch it before symptoms appear, and survival odds…
For decades, pediatric oncology has accepted that high-risk leukemia requires punishing rounds of chemotherapy — with…
Loneliness is increasingly recognized as a chronic condition rather than a passing mood—one with measurable effects on…
For anyone tracking longevity interventions, grip strength has long been treated as a reliable proxy for biological…
Catching the most common human cancer before it becomes visible to the eye — and doing so non-invasively — represents…
Cardiac amyloidosis has long been one of medicine's underdiagnosed threats — a condition that silently stiffens the…
Medical imaging is quietly experiencing its most consequential shift in decades — not through better scanners, but…
For decades, early dietary intervention in phenylketonuria was considered sufficient to normalize life outcomes. A…
Strength loss in older adults is rarely attributed to the nervous system, yet the progressive disconnection of motor…
For the millions of adults living with chronic knee pain unresponsive to physical therapy, injections, or…
Biliary tract cancers — encompassing cholangiocarcinoma and gallbladder cancer — remain among the most lethal…
For decades, the connection between menopause and accelerated cognitive decline has been clinically observed but…
Esophageal cancer ranks among the deadliest malignancies precisely because it is rarely caught early — most patients…
Understanding why mitochondria deteriorate with age—and whether that deterioration drives aging or merely accompanies…
As survival rates for blood cancers climb, the medical community faces a growing challenge: managing the cumulative…
Across 7 randomized controlled trials enrolling 50,617 adults with type 2 diabetes at high cardiovascular risk, GLP-1…
Reanalysis of the VALUE trial — a double-blind outcomes study of 15,313 hypertensive adults — finds that combining…