Studies
Triple Hormone Agonist Retatrutide Cuts HbA1c and Weight in Phase 3 Trial
For the millions of people with early-stage type 2 diabetes inadequately managed by lifestyle alone, the therapeutic…
Supplements
Amylin Analogs Cagrilintide & Petrelintide May Outperform GLP-1s on Tolerability
Amylin, a pancreatic β-cell hormone co-secreted with insulin, acts on central nervous system circuits to produce…
Fitness
High GLP-1 Discontinuation Rates Highlight Need for Post-Treatment Strategies: Narrative Review on Exercise for Lean Mass and Rebound Mitigation
When patients stop incretin-based medications like semaglutide or tirzepatide, they regain an average of 5.6 kg within…
Supplements
Resveratrol Nanoparticles Achieve 7-Fold Bioavailability Boost Via Lymphatic Route
Nanostructured lipid carriers loaded with resveratrol (RES-NLCs) delivered a 2.3-fold increase in peak plasma…
Studies
714 Mother-Infant Pairs Reveal Maternal Gut Strain Transmission and Eczema Association in Lifelines NEXT Cohort
Metagenomic sequencing of 4,526 longitudinal fecal samples from 714 Dutch mother-infant pairs (Lifelines NEXT cohort)…
Studies
Systematic Review Links Alcohol to Reduced Butyrate and Tryptophan Metabolites Across 12 Human and Primate Studies
Across 12 studies spanning humans and non-human primates, alcohol exposure consistently disrupted several gut…
Longevity
Gut Microbiome Shares Overlapping Dysbiosis Signals Across Stroke, Heart Attack, and Aging
Across an internal ischemic stroke cohort and several public datasets spanning myocardial infarction, stroke, and…
Supplements
Four Bioactive Compounds Target Complementary Aging Pathways via Distinct Molecular Mechanisms
Four mechanistically distinct natural compounds — spermidine (autophagy via EP300 inhibition), fisetin (senolysis via…
Longevity
Heart Aging Reframed: 4 Organ Axes Drive Cardiac Senescence via TMAO, EVs, Myokines
Cardiac senescence emerges from at least four pathological communication axes — epicardial adipose tissue-heart…
Longevity
Liver SIRT6 Loss Cuts Female Lifespan 17.6% via SULT1E1-Estrogen Collapse
Female mice with hepatocyte-specific SIRT6 knockout suffered a 17.6% reduction in median lifespan alongside visceral…
Longevity
GLP-1 and Multi-Agonists Linked to Substantial Visceral/Liver Fat Reductions in Reviews; Longevity Effects Remain Exploratory
A comprehensive narrative review integrating mechanistic, proteomic, epigenetic, and randomized trial data positions…
Wellbeing
Adults With Epilepsy Show Lower Social Media Addiction Despite Higher Depression
The assumption that psychiatric vulnerability automatically translates into greater digital addiction risk deserves…
Studies
AS01-Adjuvanted Shingles Vaccine Outperforms Flu Vaccine in Aging Immune Systems
Vaccine efficacy tends to erode with age — a problem so entrenched it has shaped public health recommendations for…
Studies
Multimodal AI Models May Finally Unlock Elusive Depression Brain Biomarkers
The decades-long failure to identify reliable brain biomarkers for depression isn't simply a data-volume problem — it…
Longevity
Lifetime Hormonal Contraceptive Use Linked to Greater Gray Matter Volume in Older Women
Brain aging is not uniform, and the factors that protect cortical architecture into later life remain incompletely…
Studies
APP Protein Moonlights as Nuclear Waste Removal System in Alzheimer's Pathology
For decades, Alzheimer's research has centered on amyloid precursor protein (APP) almost exclusively through the lens…
Studies
Hidden Plant Protein Unlocks Bottleneck in Anticancer Alkaloid Production
Vinblastine remains one of oncology's most clinically indispensable compounds — used in treating lymphomas, leukemia…
Studies
Dengue Virus Silences DNA Repair Machinery, Revealing Genome Instability Pathway
For the millions who survive dengue fever annually, recovery may not fully restore cellular integrity — a possibility…
Studies
Mouse Brain Vascular Protein Atlas Reveals RNA-Protein Expression Gaps
Understanding exactly which proteins are present in the cells lining and supporting brain blood vessels matters…
Wellbeing
Brain Matrix Remodeling Identified as Key Driver of Perceptual Skill Consolidation
Every hour of deliberate practice spent mastering a skill — reading fine print, distinguishing wine notes, parsing a…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.