Studies
Gene Editing in Mouse Model Explores Therapeutic Path for Peroxisomal Disorders
For patients born with peroxisomal biogenesis disorders — a group of devastating inherited conditions that rob infants…
Longevity
Senescent Fibroblasts Drive Pulmonary Fibrosis Through Self-Reinforcing Cellular Loops
Idiopathic pulmonary fibrosis kills most patients within three to five years of diagnosis, yet the cellular machinery…
Studies
Phase 3 Trial: Soticlestat Misses Primary Endpoint in Dravet Syndrome Children
For families managing Dravet syndrome — one of the most treatment-resistant childhood epilepsies — every incremental…
Studies
CGM Linked to Lower HbA1c and Mortality Risk in Type 2 Diabetes, Yet Equity Gaps Persist
Continuous glucose monitoring has long been associated with tighter control in Type 1 diabetes, but its value across…
Studies
Fertility Preservation Access for Young Cancer Patients Reveals Stark Disparities
For young women diagnosed with cancer, the chance to preserve future fertility can be as consequential as the…
Studies
Cefazolin Matches Antistaphylococcal Penicillins in S. aureus Bloodstream Infections
Bloodstream infections caused by Staphylococcus aureus carry a mortality rate that rivals many cancers, yet a…
PREPRINTNutrition
8 Proteins Map Healthy Plant-Based Diets to Lower Cancer and CVD Risk
Analyzing 7,285 circulating protein aptamers in 4,372 EPIC cohort participants, researchers identified specific…
PREPRINTLongevity
AI Model Reads Coronary Angiograms With 0.94 AUROC, Rivals Expert Cardiologists
Trained on 135,475 coronary angiography examinations comprising 812,850 multi-view videos from two Shanghai hospitals…
PREPRINTLongevity
AF Linked to Brain Changes Independently of Stroke: Large UK Biobank MRI Study with Mendelian Randomization Support
Across 502,099 UK Biobank participants, atrial fibrillation (AF) independently associated with reduced global grey…
PREPRINTStudies
cFAS + Frailty Index Predicts Limb Loss Risk 4.5× After Vascular Surgery
Among 657 patients undergoing elective vascular surgery over a decade, high circulating fatty acid synthase (cFAS)…
PREPRINTLongevity
42% Speed Drop at Home: Shorter Steps Expose Hidden Mobility Gap in 3,424 Seniors
Wearable inertial sensors tracking 3,424 older adults reveal a dramatic 0.41 m/s difference between clinical corridor…
Longevity
Oral Semaglutide Failed Symptomatic Alzheimer's Trials Despite Biomarker Gains
The EVOKE and EVOKE+ trials delivered a sobering verdict: oral semaglutide failed to slow clinical progression in…
Supplements
Narrative Review: GLP-1 Receptor Agonists May Improve Testosterone and Erectile Function Beyond Weight Loss
GLP-1 receptor agonists (GLP-1RAs) — originally developed for type 2 diabetes and now dominant obesity pharmacotherapy…
Supplements
NR Fumarate Salt Raises Blood NAD+ at 3× Lower Dose Than NMN or NR Chloride
A proprietary crystalline salt form of nicotinamide riboside — NR fumarate, branded Restorin NR — achieved blood NAD+…
Longevity
Single-Subject DELTA Protocol Integrates TRE, Mediterranean Diet, and AI Biomarkers for Healthspan
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
Studies
FGF23 Mutation Mechanisms Reveal New Targets for Phosphate Disease Treatment
Phosphate metabolism rarely makes headlines, yet its dysregulation underlies some of the most debilitating bone and…
Supplements
Genomic Map of 287 Ginseng Accessions Unlocks Ginsenoside Biosynthesis Pathway
For anyone who takes ginseng supplements or follows adaptogen research, a fundamental question has lingered: why do…
Studies
Endosomal Channel TPC1 Found to Regulate Cellular Iron Absorption Mechanism
Iron metabolism disorders—ranging from hereditary hemochromatosis to chronic anemia—affect hundreds of millions of…
Studies
3D Epigenomic Map Reveals Critical Gaps in Lab-Grown Retinal Cell Therapy
For the millions living with age-related macular degeneration and other RPE-related blinding diseases, cell-based…
Studies
Small-Molecule AT1R Agonist Challenges Decades of Cardiovascular Drug Design
For decades, the pharmacological playbook for the angiotensin II type 1 receptor has been written in one direction…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.