PREPRINTLongevity
Heart Failure Subtypes Show Opposite Damping Patterns Despite Similar Stiffness
Advanced cardiac imaging analysis of 225 patients reveals that heart failure with preserved ejection fraction (HFpEF) a…
Wellbeing
Rare 13-18 Hz Leg Tremor Reveals Network Brain Disorder
Standing upright becomes an ordeal for those with orthostatic tremor, a neurological puzzle that transforms the simple…
Wellbeing
Air Pollution Associated with Higher Seasonal Pollen Concentrations Across Multiple Plant Types
Growing respiratory allergy rates may reflect a troubling synergy between industrial emissions and natural allergens th…
Wellbeing
AI Chatbots Show Promise for Mental Health Support in HIV-Vulnerable Communities
Mental health interventions could gain critical traction in underserved populations through artificial intelligence pla…
Studies
Rural Emergency Surgery Matches Urban Trauma Center Outcomes
Emergency abdominal surgery in remote locations has long sparked debate about whether critically injured patients shoul…
Studies
Coronaviruses Hijack Host tRNA Modifications to Boost Viral Protein Production
The mystery of how coronaviruses efficiently manufacture proteins despite using genetically 'suboptimal' building block…
Studies
PRPF31 Mutation Triggers Early Müller Glia Activation Before Photoreceptor Loss
Inherited blindness may begin with subtle cellular distress signals years before patients notice vision problems, chall…
Studies
Mouse Breast Cancer Study: Cancer Stem Cells Use ISG15 Protein to Modulate Immune Defense During Metastasis
The immune system's failure to prevent metastasis may hinge on a single protein that cancer stem cells weaponize to cor…
Longevity
Astrocytes Undergo Metabolic Reprogramming During Ketone Therapy Interventions
Astrocytes—the brain's primary support cells—undergo extensive metabolic and structural changes when exposed to ketone…
Longevity
Natural Flavonoid Dihydromyricetin Targets Senescent Cells via PRDX2 Mechanism
Dihydromyricetin, a flavonoid found in Ampelopsis grossedentata (vine tea), demonstrates sophisticated senotherapeutic…
Longevity
Dietary Restriction Activates Seven Key Anti-Aging Pathways Including Autophagy
Dietary restriction triggers coordinated activation across seven distinct longevity pathways: autophagy, FGF21 signalin…
Longevity
DunedinPACE Epigenetic Clock Outperforms 13 Other Aging Biomarkers for Mortality Prediction
Among 14 consensus aging biomarkers tested in 1,083 German adults aged 60-80 over 7.4 years, the DunedinPACE epigenetic…
Wellbeing
Cognitive Training Shows Promise for Long COVID Brain Fog Treatment
Brain fog sufferers from long COVID may finally have evidence-based treatment options that can meaningfully improve the…
Wellbeing
Corn Protein Alpha-Zein Triggers Specialized Immune Tolerance Cells in Gut
The discovery that specific food proteins actively train our immune system to remain calm could reshape understanding o…
Studies
Dopamine-Enhanced Hydrogel Attracts Stem Cells for Cartilage Regeneration Without Cell Transplants
Joint cartilage damage has long frustrated both athletes and aging adults because this tissue essentially cannot heal i…
Studies
Phase 2 COMBINE Trial to Test Biologics With Multi-Food Oral Immunotherapy
Food allergy treatment could enter a new phase as researchers prepare to test whether combining powerful immune-modulat…
Studies
OGT Inhibitor Restores Brain Function in Rett Syndrome Mice
Targeting a specific metabolic pathway in the brain could offer new therapeutic avenues for rare neurodevelopmental dis…
Studies
GLP-1 Weight Loss Drugs Show Anti-Inflammatory Effects in Arthritis
The intersection of metabolism and inflammation is reshaping treatment approaches for millions suffering from both obes…
PREPRINTLongevity
CETP Gene Variants Slash Heart Disease Risk 27%, Add Disease-Free Year
Analysis of over 1.5 million people revealed that carriers of protein-disrupting variants in the CETP gene experience 2…
PREPRINTWellbeing
Edoxaban Reduces Stroke or Systemic Embolism Risk 42% vs Warfarin in Atrial Fibrillation Patients with Prior Myocardial Infarction
A comprehensive meta-analysis of five randomized trials found edoxaban reduces stroke or systemic embolism by 42% in pa…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.