PREPRINTWellbeing
Wearable PPG Sensors Could Track Heart Valve Disease Progression
Researchers developed a computational framework using peripheral photoplethysmography (PPG) signals to track aortic and…
PREPRINTLongevity
Elevated Lipoprotein(a) Shows No Real-World Stroke Risk in 97,882 Matched Adults
This federated electronic health record analysis of 97,882 matched adults found no association between elevated lipopro…
PREPRINTStudies
PEA-Risk Algorithm Predicts Deadly Cardiac Arrest with 86% C-Statistic in Training Data
Researchers developed PEA-Risk, a 12-variable clinical algorithm that predicts pulseless electrical activity sudden car…
PREPRINTLongevity
TNF-α Associated with 50% Higher Stroke Recurrence Risk
Analysis of 47,529 UK Biobank participants revealed that elevated TNF pathway proteins independently increase incident…
PREPRINTLongevity
GrimAge DNA Methylation Clock Predicts Centenarian Survival Beyond Brain Markers
Analysis of 247 cognitively healthy Dutch centenarians revealed that accelerated epigenetic aging measured by the GrimA…
Studies
AI Tools Cut Hospital Readmissions by 58% While Boosting Nursing Accuracy
Healthcare systems struggling with nursing shortages and complex patient needs may have found a powerful ally in artifi…
Supplements
Creatine Benefits Expand Beyond Strength to Endurance and Cognitive Performance
Athletic performance enhancement is evolving beyond traditional strength applications as mounting evidence reveals crea…
Longevity
Brain's Neuron-Making Capacity Compromised in Alzheimer's and Parkinson's Disease
The brain's remarkable ability to generate new neurons throughout adulthood may hold keys to understanding why some peo…
Studies
Blood Immune Signatures Detect 93% of Testicular Cancers with 99% Specificity, Including 23 of 24 Marker-Negative Cases
The challenge of diagnosing testicular cancer just became significantly easier with a breakthrough that could spare tho…
Studies
Four Molecular Breast Cancer Subtypes Show Distinct Treatment Vulnerabilities
The molecular classification of breast cancer into four distinct subtypes represents a critical shift from the historic…
Wellbeing
Childhood Internalizing Symptoms (Anxiety/Depression) Increase Adolescent Migraine Odds Nearly 3-Fold in Prospective Cohort Study
The connection between childhood mental health and physical pain conditions may be stronger and more predictable than p…
Fitness
Behavioral Theory Framework Integrated into RCT Protocol for Exercise Adherence and Cognitive Outcomes in MCI Nursing Home Residents
The gap between knowing exercise benefits cognitive health and actually sustaining meaningful activity programs represe…
Wellbeing
Metabolic Syndrome Linked to Higher Migraine Risk; Weight Loss and Exercise Reduce Episodes, GLP-1 Agonists Potential Option
People with migraine face elevated risk of developing metabolic syndrome, creating a bidirectional health challenge tha…
Wellbeing
GLP-1 Drugs Create 'Low-Drive Window' Enhancing Behavioral Weight Loss Strategies
GLP-1 receptor agonists like semaglutide create a "low-drive window" where reduced appetite and food reward sensitivity…
Longevity
Three-compound framework targets mitochondrial aging through NAD+ and antioxidant pathways
Auckland researchers propose a three-compound framework targeting mitochondrial dysfunction—a core hallmark of aging. T…
Longevity
Senolytic Therapy Timing Determines Duchenne Muscular Dystrophy Treatment Success
DBA/2-mdx mice receiving dasatinib plus quercetin demonstrated that senescent cell clearance effectiveness depends crit…
Longevity
Dendrobium officinale herb extends lifespan via context-dependent AKT modulation
Dendrobium officinale whole powder extended female fruit fly lifespan and improved climbing performance while mitigatin…
PREPRINTNutrition
Genetic Scores Identify People with 43% Greater Omega-3 Response to Fish Oil
Researchers analyzed 437,803 UK Biobank participants and found that polygenic scores—genetic risk profiles combining mu…
PREPRINTNutrition
Aged Black Garlic Shows Mixed HDL Effects in Hypertensive Adults
This triple-blind controlled trial found that 250 mg daily aged black garlic (ABG) supplementation for 12 weeks produce…
PREPRINTNutrition
Simplified Malnutrition Protocol Achieves 15% Cost Reduction, Higher Recovery Rates
A 229-child prospective cohort study in Venezuela found that a simplified acute malnutrition protocol achieved superior…
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