Wellbeing
Tree Canopy Cover Linked to Lower Depression Scores in Older Adults Over 12 Years
For aging populations, the places where people live may matter as much as the medicines they take. Most mental health…
Studies
6-Strain GBS Conjugate Vaccine Shows Safety and Infant Antibody Transfer in Phase 1/2 Trial
Group B Streptococcus remains one of the leading causes of life-threatening sepsis and meningitis in newborns…
Wellbeing
Depression's $12 Trillion Global Cost Projected Across 154 Nations by 2050
Mental health rarely commands the same urgency as cardiovascular disease or cancer in public health investment…
Studies
Updated Spanish Guidelines Reframe Alpha-1 Antitrypsin Diagnostic Thresholds and Testing Protocols
Genetic lung disease often hides in plain sight: millions of people carry severe alpha-1 antitrypsin deficiency (AATD)…
Studies
Glymphatic Clearance Biomarker Links Brain Waste Removal to Alzheimer's Severity
Brain waste clearance is emerging as one of the most consequential mechanisms in Alzheimer's disease prevention, and a…
Studies
Phase 3 Trial: Specialist Long COVID Care Improves Fatigue Across All Treatment Arms
For the millions still navigating the debilitating aftermath of COVID-19 infection, clarity about what actually works…
Wellbeing
Perspective: Digital Cognitive Tests Could Help Bridge Gap Between Blood Biomarkers and Early Alzheimer's Detection
A profound mismatch has quietly undermined the promise of Alzheimer's early detection: blood tests can now identify…
Studies
Enteric Disease Deaths Fell ~66% Since 1990, Yet Progress Stalls in Poorest Regions
Despite decades of global health investment, diarrhoeal and enteric diseases remain a leading killer of young children…
Studies
New Alzheimer's Antibodies Fail Cost-Effectiveness Tests at Standard Thresholds
As the first disease-modifying therapies for Alzheimer's reach patients, a critical question emerges: do their…
Studies
Updated Spanish Guidelines Redefine Alpha-1 Antitrypsin Screening and Augmentation Thresholds
A severely underdiagnosed genetic condition silently destroys lung tissue for years before most patients receive a…
Wellbeing
Glymphatic Waste Clearance Failure Linked to Migraine via CGRP Accumulation
Migraine affects roughly one billion people globally, yet its underlying biology remains poorly understood — a gap…
Studies
Dismantling a Protein Shield May Overcome Lung Cancer Drug Resistance
Drug resistance remains one of the most frustrating obstacles in oncology, and for the millions of patients with…
PREPRINTLongevity
Novel AKT1/mTOR/RICTOR Gain-of-Function Variants Linked to Hypertrophic Cardiomyopathy in Indian Cohort
Exome sequencing of an Indian hypertrophic cardiomyopathy (HCM) cohort uncovered six heterozygous missense variants…
PREPRINTLongevity
Evolocumab Clears $71K/QALY Threshold in High-Risk Patients Before First Heart Attack
A Markov lifetime-horizon model adapted from the VESALIUS-CV trial finds that adding evolocumab to standard therapy in…
PREPRINTLongevity
48,000-Person Genome Scan Maps 52 Loci Associated with Right Ventricular Trabeculation
Applying deep-learning image segmentation and fractal dimension analysis to cardiac MRI data from 48,118 UK Biobank…
PREPRINTLongevity
Preprint Compares Aging Rates and Policy Gaps in Spain, Italy, Chile, and Colombia
A mixed-methods comparative case study across Spain, Italy, Chile, and Colombia reveals a stark demographic…
PREPRINTLongevity
Self-Test Cognitive Battery Detects Dementia With 91% Sensitivity in 37,000-Person Validation
Across 36,941 participants — 35,822 healthy adults, 1,046 with Mild Cognitive Impairment (MCI), and 73 with dementia…
Studies
3D Genome Disruption Drives Infant-Onset Gigantism via GPR101 Overactivation
Understanding why some children experience explosive, uncontrolled growth before their second birthday has long…
Longevity
GLP-1 Agonists Cut CV Risk, But Anti-Inflammatory Mechanism Remains Unproven in Humans
Incretin-based therapies — particularly GLP-1 receptor agonists like semaglutide — reduce cardiovascular events in…
Studies
Gradual Semaglutide Tapering vs. Abrupt Stop: RCT Tests Weight Regain
A registered randomized controlled trial (NCT07294950) from Mount Sinai Hospital, Toronto, will compare gradual…
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