PREPRINTLongevity
5M-Patient Model Reveals 18% of Adults Have Unrecognized or Untreated Hypertension
A three-axis classification model applied to 5,129,584 Japanese adults from a national health insurance database…
PREPRINTStudies
Polymer-Free Everolimus Stent Achieves 1.5% Failure Rate in 1,000 High-Risk PCI Patients
The TRANSEVER registry—a 33-centre Indian prospective study—tracked 1,000 consecutive patients receiving the…
PREPRINTWellbeing
Depression Linked to 36% Higher CVD Prevalence in Haiti's Urban Adults
Among 2,995 adults enrolled in the Haiti Cardiovascular Disease Cohort (2019–2021), moderate-to-severe depressive…
Supplements
Resveratrol Blocks HSF1-Driven Necroptosis to Shield Liver From Heatstroke
Resveratrol pretreatment in mouse heatstroke models and AML12 hepatocyte heat-exposure assays significantly reduced…
Longevity
DMA Triple-Drug Combo Extends Lifespan in Old Mice at 10x Lower Navitoclax Dose
A UC Berkeley team demonstrated that combining dichloroacetate (DCA), metformin, and a 10-fold reduced dose of…
Longevity
MSC-Derived Exosomes Reverse Liver Fat Accumulation in Aged Mice via Autophagy
Declining liver function in aging is rarely front-of-mind until it manifests as fatty liver disease or insulin…
Longevity
NaV1.4 Channel Loss at Aging Muscle Junctions Reveals Reversible Sarcopenia Mechanism
Muscle weakness in aging has long been attributed to shrinking muscle fibers and declining motor neurons — but a new…
Studies
Measles Brain Complication Shares Viral Mutation Patterns With Animal Morbillivirus Disease
As measles vaccination rates slide globally, a rare but invariably fatal brain complication is poised to resurge — and…
Studies
Spring Clock-Forward Linked to 34% Higher Proliferative Diabetic Retinopathy Risk
Circadian disruption is increasingly recognized as a cardiovascular risk factor, but its impact on the microvascular…
Studies
Lung Cancer's Shifting Microenvironment May Hold Keys to Beating Treatment Resistance
Treatment resistance in non-small cell lung cancer remains one of oncology's most stubborn problems, and mounting…
Studies
T Cell-Targeted Vaccine Design May Unlock Durable Mucosal Immunity
For decades, vaccine development has centered on generating neutralizing antibodies — a strategy that works well…
Studies
IFN-α Identified as Causal Driver of Distinct Sjögren's Disease Endotype
Precision medicine in autoimmune disease has long been stymied by biological heterogeneity — patients carrying the…
Studies
ApoB-Guided Lipid Therapy Offers Better Value Than LDL-C Targets
For decades, LDL-C has been the default target guiding statin therapy decisions, yet mounting evidence suggests it…
Nutrition
Low-Sodium Maternal Diet Disrupts Offspring Brain Development via Epigenetic Mechanisms
Dietary sodium restrictions during pregnancy and lactation are widely practiced and often encouraged, yet the…
Supplements
Collagen Peptides Boost Bone Formation Markers in Female Distance Runners
For premenopausal women logging serious mileage, bone stress injuries remain a stubborn clinical challenge — one that…
Supplements
Resveratrol Targets SIRT1/AMPK and NF-κB to Counter Four Neurodegenerative Diseases
Resveratrol, a polyphenolic phytoalexin concentrated in grapes and red wine, modulates at least four interconnected…
Studies
Six Plasma Proteins Mediate Obesity's Causal Path to Heart Structural Damage
Understanding precisely how excess body fat reshapes the heart — independently of diabetes, hypertension, or…
Studies
Alcohol and HIV Converge in South African Young Women via Social Syndemic Pathways
Among the most vulnerable populations globally, adolescent girls and young women in sub-Saharan Africa carry a…
Studies
Gonorrhea Resistance to Penicillin Nearly Doubled in One Year
Drug-resistant gonorrhea has been an escalating global public health concern for decades, but the pace of resistance…
Studies
Cryo-EM Reveals How Maternal Antibodies Lock Platelets in Inactive State
A rare but devastating pregnancy complication may soon yield to more targeted therapies, thanks to atomic-level…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.