Wellbeing
Pakistan Suicide Data Gap Exposed: Females and Youth Bear Highest Risk
Suicide surveillance blind spots in low- and middle-income countries don't just obscure statistics — they actively…
Studies
RARβ Agonist KCL-286 Cuts Neuronal DNA Breaks and Brain Inflammation in Alzheimer's Mice
One of the most frustrating gaps in Alzheimer's therapeutics is the lack of agents that address the disease's earliest…
Studies
Finerenone's Dual Cardiorenal Shield: Mechanisms and Trial Evidence Reviewed
For the millions of adults navigating the dangerous intersection of chronic kidney disease and cardiovascular…
Studies
RARβ Agonist KCL-286 Repairs Neuronal DNA Breaks in Alzheimer's Mouse Model
One of the most underappreciated features of early Alzheimer's pathology is the accumulation of DNA double-strand…
Studies
Finerenone's Dual Cardiorenal Protection: Mechanisms and Trial Evidence Reviewed
For the roughly one in three adults with chronic kidney disease who also carry elevated cardiovascular risk, the…
Studies
Gut Microbiome Depletion Suppresses Pancreatic Tumor Growth and Boosts Chemotherapy
Pancreatic ductal adenocarcinoma remains one of the deadliest cancers, with five-year survival rates below 12% and…
Studies
Aedes Saliva Molecule Found to Modulate Immune Response During Chikungunya Infection
Understanding why some mosquito-borne viral infections cause severe disease while others remain mild has long puzzled…
PREPRINTStudies
AI Clusters Dilated Cardiomyopathy Into 3 Prognostic Phenotypes via MRI
Applying unsupervised machine learning to 347 non-ischemic dilated cardiomyopathy (NIDCM) patients across two tertiary…
PREPRINTLongevity
Abnormal Sleep Duration Nearly Doubles Atrial Flutter Risk Post-Ablation
Among 720 participants in the PREDIMAR randomized controlled trial — a Mediterranean diet intervention study tracking…
PREPRINTLongevity
AI-Guided Self-Titration Hits 88% Time-in-Range for Heart Failure Patients in 90-Day Trial
Applying the insulin self-management paradigm to heart failure, the SURPASS-HF trial enrolled 21 adults (mean age…
PREPRINTLongevity
RCRI Score ≥3 Associated with ~49-Fold Higher Odds of Unplanned Surgical Admission in ATTR-CM Patients (Preprint)
Among 51 ATTR-CM patients undergoing non-cardiac surgery drawn from a 145-patient real-world cohort, a Revised Cardiac…
PREPRINTLongevity
Wearable NIRS Shows Differences in Heart Failure Patients With Identical 6-Minute Walk Distances: medRxiv Pilot Study
In a 44-patient pilot study of chronic heart failure outpatients (mean age 70.9 years), wearable near-infrared…
Studies
Global Mental Disorder Burden Mapped Across 204 Nations Over Three Decades
Mental health has long been underfunded relative to its share of global disease burden, and this landmark analysis…
Studies
Bidirectional Neuroprosthesis Yields Lasting Hand Recovery After Complete Tetraplegia
For the millions living with spinal cord injury, the prospect of regaining not just movement but sensation — and…
Studies
GLP-1 Agonists Show No Clear Advantage Over Other Agents for Insulin Discontinuation
For the millions of people with type 2 diabetes who take daily basal insulin injections, the prospect of eventually…
Studies
Immunopeptidomics Uncovers Conserved Malaria Antigens Enabling Cross-Stage Vaccine Design
The possibility of a single vaccine offering protection against multiple species of malaria — and across the…
Longevity
GPR40 Receptor Activation Reverses Thymic Aging in Mouse Model
Immune deterioration with age has long been attributed partly to the shrinking thymus, but pinning down a druggable…
Longevity
SIRT3 Loss in Aging Stem Cells Drives Chronic Inflammation Via Myeloid Reprogramming
One of the most persistent puzzles in aging biology is explaining why the immune system shifts from a protective force…
Studies
Dual HIF-1/2 Inhibitor Achieves 50%+ Complete Responses in Mouse Models of Five Cancer Types
One of the most stubborn challenges in oncology is that tumors engineer their own survival environment — starving…
Wellbeing
One-Third of US Women Uncertain About Perimenopause Stage, Survey Finds
Perimenopause remains one of the most clinically under-served transitions in women's health, and a major reason may be…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.