APOE4 Gene Triggers Brain Hyperexcitability Decades Before Alzheimer's Symptoms

Brain circuits may begin malfunctioning decades before Alzheimer's disease symptoms emerge, offering a critical window…

STAG2 Protein Loss Drives Aggressive Ewing Sarcoma Through Microsatellite Enhancers

Understanding how rare but deadly childhood cancers develop their aggressive characteristics could transform treatment…

Evening-Heavy Eating Patterns Increase Frailty Risk in Korean Seniors

The timing of meals may be as crucial as their content for maintaining physical independence in later life. Two problem…

Combined NMN-Apigenin Protocol Reverses Age-Related Muscle, Bone, and Cartilage Decline in Aged Mice

Age-related musculoskeletal decline represents one of the most significant barriers to healthy longevity, affecting mob…

Shortwave Diathermy Reduces Post-Surgery Lymphedema Swelling by Seven Measures

Cancer survivors facing chronic arm swelling after breast surgery may find relief through an underutilized heat therapy…

E-Cigarette Metal Particles Accumulate Unevenly in Lung Tissue Study Finds

The presumed safety advantage of e-cigarettes over traditional tobacco may be undermined by an overlooked hazard: toxic…

Blocking Ghrelin Receptors Preserves Muscle Strength and Endurance in Aging

Age-related muscle decline affects virtually every adult over 50, yet no approved medications exist to combat this inev…

Metabolic Aging Clocks Identify Alpha-Ketoglutarate as Key Longevity Driver

The quest for actionable aging biomarkers has taken a significant leap forward with the development of organ-specific m…

SKIP

Nurse Empathy Predicts Better Patient Care Across Cultural Boundaries

Healthcare systems increasingly serve diverse populations, yet the psychological factors that enable nurses to deliver…

Gene Editing Targets Fetal Hemoglobin Promoters for Sickle Cell Treatment

Adults living with inherited blood disorders may soon have access to a fundamentally different therapeutic approach tha…

New Intrinsic Capacity Score Predicts Disease Risk Across 500,000 People

A comprehensive health scoring system combining cognition, movement, sensory function, vitality, and psychological well…

GPS Tracking Links Spatial Racism to Daily Sleep and Stress in Young Minorities

A novel GPS-based methodology tracked 32 young sexual and gender minorities of color across New York City neighborhoods…

Shingrix Zoster Vaccine Associated With 26% Lower All-Cause Mortality Risk in Dementia Patients

A large-scale analysis of 68,960 US dementia patients found that those receiving the recombinant zoster vaccine Shingri…

1918 Swiss Flu Data Reveals Morbidity-Mortality Patterns Diverge

Analysis of Swiss data from the 1918-1920 influenza pandemic reveals that factors driving illness rates differ substant…

Early-Life Social Class Predicts Long-Term Memory Accuracy 50 Years Later

Analyzing 62-year-olds from Britain's 1958 birth cohort, researchers found that social class origins cast a shadow over…

Arginine Cluster Engineering Boosts CAR-T Cell Tumor Killing Efficacy

A novel protein engineering approach could dramatically enhance one of medicine's most promising cancer treatments by a…

Semaglutide's 15% Weight Loss May Require Earlier Bone Monitoring

A 65-year-old woman achieved 15% weight loss on semaglutide over one year, improving her blood pressure, lipid profile,…

Geroscience Targets Four Aging Hallmarks to Delay Multiple Chronic Diseases

Scientists identify four core biological drivers that fuel multiple age-related diseases simultaneously: genomic instab…

High-Salt Diet Triggers Vascular Aging Through IL-16 Immune Pathway

A 28-day high-salt diet (8% NaCl) induced endothelial dysfunction in mice through cellular senescence rather than direc…