PREPRINTStudies
GLP-1 Drugs Linked to 29% Lower Post-COVID Death Risk in Diabetics vs. SGLT2i (Preprint)
Among 14,215 adults with type 2 diabetes and COVID-19 (mean age 60, mean BMI 37), prescription of GLP-1 receptor…
PREPRINTStudies
Under 10% of Clinical Trials Report Equity Data Beyond Age and Sex
A feasibility audit of 98 Phase II and III pharmacological randomised controlled trials — drawn from 1,328…
PREPRINTLongevity
16 CVD Risk Scores Tested Head-to-Head: PREVENT Tops 438,640-Person Validation
Among 438,640 UK Biobank participants free of cardiovascular disease at baseline, 45,003 incident CVD events occurred…
Studies
Synthetic AMH-Mimicking Peptide Shields Ovarian Reserve From Chemotherapy Damage
Chemotherapy-induced infertility and early menopause represent a largely unaddressed consequence of cancer treatment…
Studies
Extracellular Vesicles Emerge as Dual Biomarker and Therapy Platform for Neurodegeneration
For anyone tracking the frontiers of Alzheimer's, Parkinson's, or ALS research, a single technology that could…
Studies
34 Blood circRNAs Outperform pTau217 in Preclinical Alzheimer's Detection
Catching Alzheimer's disease before a single symptom appears has long been the field's most frustrating gap — existing…
Studies
Progestogen Monotherapy Offers Viable Menopause Relief When Estrogen Is Contraindicated
For millions of women navigating menopause with histories of venous thromboembolism, certain gynecologic cancers, or…
Studies
Female Alzheimer Caregivers Bear Heavier Burden Across Seven Nations
Alzheimer's disease is often discussed through the lens of the patient, but the invisible workforce sustaining that…
Longevity
700–900 METs/Week Exercise Peaks Gut Diversity and Akkermansia in Aging Adults: Meta-Analysis
Across 16 trials pooled in this systematic review and meta-analysis, exercise interventions in older adults produced…
Studies
Dopamine D4 Receptor Activation Curbs Opioid Tolerance Without Blunting Pain Relief
One of the most vexing failures in pain medicine is not that opioids stop working — it's that they can make pain…
Studies
AETA Peptide Contributes to Sex-Biased Synaptic Dysfunction in Alzheimer's Disease
The biological mechanisms linking amyloid precursor protein (APP) processing to early synaptic failure in Alzheimer's…
PREPRINTWellbeing
TBI History Linked to Higher Mood Disorder Risk in Dementia, Stroke, Parkinson's Patients: UK Biobank Preprint
Among 502,154 UK Biobank participants, individuals carrying both a lifetime traumatic brain injury (TBI) history and a…
PREPRINTLongevity
Social Vulnerability Scores Linked to 5-Year Equivalent Cognitive Aging in 5,989 Adults
Among 5,989 Americans aged 60+ drawn from NHANES cycles spanning 1999–2014, a newly constructed individual-level…
PREPRINTStudies
Lassa Fever Kills 39% of Confirmed Cases in Nigerian State Over 5 Years
A retrospective analysis of 1,624 suspected Lassa fever cases in Ebonyi State, Nigeria (2019–2023) found a case…
PREPRINTStudies
Gut Metabolite TMAO Associated with Fewer Behavioral Problems in Children and Protection Against Heavy Metal Neurotoxicity in Preprint Study
Trimethylamine N-oxide (TMAO), a gut microbiota-host co-metabolite, associates with fewer internalizing behavioral…
PREPRINTNutrition
Fermentable Fiber Cuts Uremic Toxins IS and pCS in Kidney Disease Patients
A systematic review and meta-analysis pooling 13 randomized clinical trials (511 participants) and 15 controlled…
Wellbeing
Storytelling RCT Cuts Bereavement Anxiety in Dementia Family Caregivers
Bereavement after caregiving for a loved one with dementia carries a distinct psychological burden — one layered with…
Studies
Artemisinin Resistance Markers Emerging in East African Hotspots, Spatiotemporal Study Maps Prevalence
The frontline drugs for malaria — artemisinin-based combination therapies — have held for decades, but a growing body…
Studies
JAK/STAT Pathway Review Maps Therapeutic Gaps in Autoimmune, Malignant, and Other Disease Areas
Understanding why some people respond to anti-inflammatory drugs while others develop resistance or serious side…
Studies
Mendelian Randomization Study Links Genetic Proxies of GLP-1 Receptor Activity to Lower Breast/Prostate Cancer Risk and Higher Thyroid Cancer Risk
Drug-target Mendelian randomization using genetic variants in the GLP1R gene region as instruments—analyzed across 21…
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