Studies
SEMA6A Gene Variants Linked to Autism, Intellectual Disability in Small Cohort
Understanding the genetic underpinnings of neurodevelopmental disorders remains one of the most clinically urgent…
Studies
Camizestrant Visual Side Effects Mild and Reversible in Phase III Breast Cancer Trial
For women with ER-positive advanced breast cancer whose tumors develop ESR1 mutations during first-line therapy, the…
Studies
Mitochondrial Antioxidant PRX3 Inhibition Shows 67% Disease Control in Mesothelioma Trial
Mesothelioma ranks among oncology's most intractable diagnoses, with median survival measured in months and few…
PREPRINTNutrition
3 Days of CGM Captures Individual Glucose Response Traits as Well as 14 Days
A multivariate mixed-effects machine-learning model applied to 50,463 free-living meals from 992 non-diabetic adults…
PREPRINTNutrition
Three Thiamine Measures Diverge: TDP, Diet, and Enzyme Function Tell Different Stories
A pilot study measuring thiamine diphosphate (TDP), erythrocyte transketolase activity (TKT), and activity…
PREPRINTLongevity
Atrial Fibrillation Raises Injurious Fall Risk 89% in Hypertensive Adults
Among 8,807 hypertensive adults enrolled in the SPRINT trial, atrial fibrillation (AF) was independently associated…
PREPRINTLongevity
Blood Pressure Drives 71% of Global CVD Mortality Decline; BMI Acts Entirely Through Metabolic Intermediaries
Age-standardized cardiovascular mortality fell from 340.2 to 258.4 deaths per 100,000 globally between 2000 and 2023…
PREPRINTLongevity
Shunt Insertion Angle Predicts Thrombosis Risk in 8-12% of Infant Heart Surgeries
In 10 infant patients with cyanotic or single-ventricle heart disease, patient-specific computational fluid dynamics…
Longevity
GLP-1 Therapies Show Promise for Women's Cardiometabolic Risk, But Sex-Specific Data Remain Scarce
Women's cardiometabolic risk from obesity follows distinct hormonal trajectories—from menarche through menopause—that…
Longevity
Gut Dysbiosis Depletes SCFAs, Driving Bone Loss in Elderly via NF-κB Inflammation
Aging-associated gut dysbiosis — marked by depletion of short-chain fatty acid (SCFA)-producing bacteria, accumulation…
Wellbeing
Cumulative IPV Relationships Compound Depression and Trauma Symptoms in Both Partners
The mental health toll of intimate partner violence is often framed around individual incidents, but the cumulative…
Studies
Interleaved Learning Advantage Survives Rigorous Forced-Choice Memory Test
One of the most widely cited findings in cognitive science — that mixing different subjects during study sessions…
Studies
SARM1 Axon-Degeneration Enzyme Not Directly Activated by Double-Stranded DNA
Understanding what switches on the axon self-destruction program matters enormously for conditions ranging from…
Studies
Rosette Cell Clusters Drive Pancreatic Cancer Organoid Self-Assembly Mechanics
Understanding how cancer cells self-organize into tissue-like structures may be one of the most underappreciated…
Wellbeing
Frontolimbic Brain Wiring From Birth Shapes Cognition Under Adversity
How the brain's emotional and cognitive circuits wire themselves across the first two decades of life has profound…
Studies
Tumor-Immune Spatial Patterns Yield Transcriptomic Biomarkers Predicting Cancer Progression
Understanding why some tumors respond to immunotherapy while others evade it remains one of oncology's most pressing…
Supplements
Gut Bacterium's Anti-Inflammatory Power Traced to Single Metabolite
Understanding why the same probiotic species produces dramatically different health outcomes across individuals has…
Studies
Antiviral Protein MAVS Doubles as Hypoxia Survival Regulator via Mitochondrial ROS
A protein long confined in immunology textbooks to antiviral defense turns out to play a parallel role in one of cell…
Studies
crRNA Scaffold Mutation Solves Key Sensitivity Tradeoff in One-Pot CRISPR Diagnostics
Rapid pathogen detection sits at the intersection of molecular biology and public health preparedness — and a…
Studies
Short AR Gene Repeats Amplify Androgen-LSD1 Signaling, Rewiring Prostate Cancer Metabolism
For decades, the androgen receptor's CAG repeat polymorphism has sat at the edge of prostate cancer research…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.