Fitness
Six Decades of European Youth Fitness Data Reveal Alarming Declining Trends
Youth fitness trajectories serve as a leading indicator of population health decades before chronic disease burdens…
PREPRINTStudies
AI Model Automates Key Echo Parameters (VTI, Atrial Areas) With R² Up to 0.88 Across Multi-Cohort Datasets
Trained on 186,712 sonographer-annotated echocardiographic images from 93,978 studies across 56,855 patients at…
PREPRINTLongevity
Blood miRNA miR-664a-3p Associated with Coronary Plaque Burden in Small Indian Study (AUC 0.84-0.88)
A blood-based microRNA signature may reveal coronary plaque instability without invasive imaging. In two independent…
PREPRINTLongevity
High Urinary Na/K Ratio Doubles Brain White Matter Lesion Odds in Older Adults
Among 296 community-dwelling Japanese adults (mean age 68.7), those in the highest quartile of 24-hour urinary…
PREPRINTFitness
6-Minute Walk Distance Links to Episodic Memory in Sedentary Adults Over 70
Among 58 sedentary, cognitively unimpaired older adults (mean age 70.7 years, 84.5% female), greater 6-minute walk…
PREPRINTWellbeing
Dementia Patients Back AI Medication Reviews—With Key Conditions Attached
Among 12 people living with dementia (PLwD) and 14 carers recruited across two focus groups, qualitative interviews…
Longevity
GLP-1 Agonists, SGLT-2 Inhibitors & VLEKT: Narrative Review Maps Potential Targets in Obesity's Four Key Complications
Obesity's cardiometabolic cascade operates through four converging pathways: upper-airway collapsibility driving OSAS…
Studies
GLP-1 Agonists in Breast Cancer: Attenuated Weight Loss, Survivorship Signals Emerge
Breast cancer patients using GLP-1 receptor agonists (GLP-1RAs) achieve meaningful but measurably smaller weight…
Longevity
Circadian Clock Collapse in CKD: Melatonin's 6-Pathway Renoprotective Case
In chronic kidney disease, retained uremic toxins and sustained NF-κB activation actively suppress the kidney's…
Longevity
Advances in Sarcopenia Management: Exercise, Nutrition (1.2–1.5 g/kg Protein), and Emerging Pharmacotherapies like Bimagrumab and Metformin
Sarcopenia management is converging on a multi-modal clinical framework, with protein thresholds of 1.2–1.5 g/kg/day…
Nutrition
Review: Balanced EAAs + Resistance Training May Promote PGC1-α-Independent Mitochondrial Biogenesis and Muscle Remodeling
Essential amino acids (EAAs) consumed in the post-absorptive state—not just peri-workout—drive mitochondrial…
Fitness
BDNF, IGF-1, and Cerebral Flow: How Exercise Reshapes the Aging Brain
Among community-dwelling adults over 60 — a population facing a 4.5% annual cumulative incidence of depression…
Fitness
Exerkines BDNF and VEGF Link Exercise Directly to Brain Neuroprotection Mechanisms
Physical inactivity constitutes a measurable risk factor for neurodegeneration, with exercise triggering release of…
Longevity
Non-drug VCID interventions show 3× cognitive gains, 5× functional improvement over pharmacotherapy
Vascular cognitive impairment and dementia (VCID) — carrying 30% higher mortality than Alzheimer's — currently lacks…
Supplements
Resveratrol Cuts Alveolar Bone Loss Up to 60% in Animal Periodontitis Models
Across 22 studies — 16 preclinical and 6 randomized clinical trials — resveratrol consistently reduced alveolar bone…
Studies
STING Pathway in Immune Cells Triggers Colorectal Tumor Death via Ferroptosis Mechanism
For the millions of patients diagnosed with colorectal cancer annually — a disease notorious for its resistance to…
Studies
Photosensitizer Selectively Destroys Antibiotic-Resistant Bacteria Using Their Own Defense Enzymes
Antibiotic resistance kills an estimated 1.27 million people annually, and conventional antibiotics paradoxically…
Studies
Single Rice Gene Controls Both Cold Stress and Fungal Blast Resistance Simultaneously
Food security in a warming yet climatically volatile world depends on crops that can endure both environmental…
Studies
Two Small Molecules Disrupt Lipid Raft Order Via Protein-Dependent Mechanism
Cell membrane architecture may be far more druggable than previously assumed. Lipid rafts — highly ordered…
Studies
MDM2 Protein Suppresses c-Myc via mRNA Translation Block, Opening Cancer Therapy Path
One of oncology's most frustrating paradoxes has been the near-undruggability of c-Myc — a transcription factor…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.