Studies
51-Trial Meta-Analysis Finds Blood Pressure Drug Benefits Don't Compound Over Time
For decades, the standard clinical assumption has been that staying on blood pressure medication longer yields…
Studies
Prior H1N1 Exposure Builds Partial Cross-Immunity Against H5N1 Neuraminidase
If H5N1 bird flu ever achieves sustained human transmission, the pandemic toll may not fall equally across all age…
Studies
Alcohol Industry Opposed 99% of Pregnancy Label Proposals in Australia-NZ
When public health policy collides with commercial interests, the lobbying record tells a revealing story…
Wellbeing
Gendered Digital Environments Linked to Distinct Mental Health Risks in Young Males
The mental health conversation around screen time has long centered on girls and young women — but a growing body of…
PREPRINTStudies
ML Screens Undiagnosed Hypertension With Just 8 Non-Invasive Variables—But AUC Barely Clears 0.61
Among 5,237 NHANES 2017–2018 participants, 20.5% (n=1,072) met criteria for probable undiagnosed hypertension (mean BP…
PREPRINTStudies
POAF After Bypass Surgery Extends Stay 30% But Doesn't Drive 90-Day Readmissions
Among 4,684 adults undergoing isolated coronary artery bypass grafting (CABG) in Florida between 2021 and 2024…
PREPRINTLongevity
5-Phenogroup Model Reveals Lean-IR Patients Face 1.86x MI/Stroke Risk
Latent class analysis applied to 1,034 participants (RESET cohort) using 14 cardiometabolic variables—six conventional…
PREPRINTLongevity
Custom 47,027-SNP Array Detects 84% of FH Variants Across Multi-Ethnic NZ Cohort
A custom Illumina Global Screening Array — branded Holo-Q Omniscan Waka Te Ira — was engineered with 43,437 added SNPs…
PREPRINTStudies
Whole Exome Sequencing Finds 9% of MVP Patients Carry High-Risk Arrhythmia Genes
In 203 consecutive mitral valve prolapse (MVP) patients without other arrhythmic substrates, whole exome sequencing…
Studies
Telehealth Stepped Alcohol Treatment Cuts Drinking in Liver Disease Patients
For the millions of people managing chronic liver disease while also struggling with alcohol use disorder, finding an…
Supplements
5 Polyphenols Target ADPKD Cyst Growth via 4 Simultaneous Pathways
Five plant-derived polyphenols — resveratrol, curcumin, naringenin, quercetin, and EGCG — demonstrate preclinical…
Nutrition
Polyphenols Raise LDL Numbers Yet Cut Oxidized LDL 65% in Equol Producers
A randomized, placebo-controlled crossover trial (PolyPAUSE, n=90 mildly hypercholesterolemic postmenopausal women)…
Supplements
Resveratrol Fights Obesity via p38-ATF3-GDF15 Brain Signaling Cascade
Resveratrol dose-dependently upregulates GDF15 mRNA, protein expression, and secretion in both murine embryonic…
Nutrition
Gut-Microbiota Diet Score Linked to 22% Lower MASLD Risk in 168K UK Biobank Adults
Among 168,456 UK Biobank participants followed prospectively, those scoring ≥6 on the Dietary Index for Gut Microbiota…
Nutrition
Gut Metabolite ImP Associated with 82% Higher CHD Risk in Cohorts; Pectin Intake May Modulate Levels
Plasma imidazole propionate (ImP)—a microbial metabolite of histidine produced via the urocanate reductase pathway—was…
Longevity
Ergothioneine Mediates 31.5% of Antacid-Linked Cognitive Decline Risk
Screening 991 blood metabolites against cognitive performance and brain MRI markers in 1,082 dementia-free middle-aged…
Longevity
Diabetes Alters 4 Gut Taxa in Elderly Nursing-Home Residents, Not Diversity
In 173 nursing-home residents averaging 86 years of age (77.5% female), diabetes mellitus — present in 51 participants…
Longevity
Gut Metabolite ImP Potentiates Tau Hyperphosphorylation via GSK-3β and Alzheimer's Pathology
In a 1,196-person cognitively unimpaired cohort, elevated plasma imidazole propionate (ImP) — a gut bacterial…
Longevity
45,454 Gut Microbiomes Link Medication-Associated Oral Bacteria to Aging-Disease Microbiome Overlap
A computational re-examination of 45,454 gut microbiomes across 141 studies identified 15 microbial taxa…
Longevity
16-Microbe Gut Signature Discriminates Frailty Across 28 Cohorts, 24 Countries
Across 955 individuals drawn from 28 independent cohorts spanning 24 countries, a metagenomic meta-analysis pinpointed…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.