Longevity
Mitochondrial Metabolite FAD Found to Suppress Two Key Innate Immune Sensors
Chronic low-grade inflammation is one of the most consistent hallmarks of biological aging, yet the precise molecular…
Longevity
Dual Aging Pathways—Inflammaging and Immunosenescence—Converge to Drive Colorectal Cancer Risk
Colorectal cancer rates climb steeply after age 60, yet the biological explanation has remained frustratingly…
Studies
Six Viruses Linked to MS Onset via Shared Immune-Disruption Pathways
Multiple sclerosis affects nearly 2.9 million people globally, yet its root cause has resisted a clean explanation for…
Longevity
Social Disadvantage Linked to Accelerated Biological Aging via Epigenetic Clocks
The gap between chronological age and biological age may be one of the most consequential — and modifiable — health…
Studies
Single mRNA-1083 Dose Sustains Dual Flu-COVID Immunity Six Months in Over-50s
For adults over 50 who already manage separate annual flu shots and COVID boosters, the prospect of a single injection…
PREPRINTNutrition
DII Associated with Lower Cognitive Scores in Older Adults, But Food-Based Score Shows No Link
Among 2,455 adults aged 60 and older in NHANES 2011–2014, each one standard-deviation increase in the Dietary…
PREPRINTNutrition
Boysenberry-Apple Blend Cuts Children's Cold Duration by 3 Days in RCT
A double-blind, randomized, placebo-controlled trial of 84 children aged 5–13 found that twice-daily chewable tablets…
PREPRINTLongevity
PAD Patients Show Blood Epigenome Shift Toward Embryonic Vascular Programs at 16,854 Genes
Blood DNA methylation analysis of 10 PAD patients (mean age 72.7 years) versus 22 age-matched controls identified…
PREPRINTLongevity
Bangladeshi Men Face 2.8× Higher Premature Heart Attack Risk by Age 45
Analyzing 14.8 million adults across 80.9 million person-years in England's primary care database, this large…
PREPRINTLongevity
Four Data-Driven Brain Clusters Redefine Alzheimer's Diagnostic Boundaries in 515 Adults
Applying Similarity Network Fusion to 515 ADNI participants, researchers integrated structural MRI metrics (cortical…
Studies
Combined mRNA Flu-COVID Vaccine Sustains Dual Antibody Responses Six Months Post-Dose
For adults over 50 who already navigate the annual ritual of separate flu and COVID shots, the prospect of a single…
Studies
PNAS Commentary Highlights Pyrophosphate-Mediated Backtracking in Ribozyme RNA Copying for Improved Fidelity
Accurate copying of genetic information sits at the very heart of cellular life — and increasingly, of RNA-based…
Studies
Fruit Fly Injury Model Reveals Tau-Microtubule Mechanisms Linked to Aggression, Offering Insights into CTE
Chronic traumatic encephalopathy remains one of the most difficult neurodegenerative conditions to study precisely…
Wellbeing
Psychological Inoculation Improves Discernment of Climate Doom on Social Media Simulator
Emotional resilience to algorithmically amplified catastrophism has become a genuine public health concern, not merely…
Studies
RelB-Notch2 Molecular Axis Controls Gut-Resident Dendritic Cells Driving IL-23 Immunity
Understanding precisely how the intestinal immune system distinguishes dangerous pathogens from harmless dietary…
Studies
Myasthenia Gravis Patients with Type I IFN Autoantibodies Face Elevated Risk of Hypoxemic COVID-19 Pneumonia
A convergence of two distinct immune vulnerabilities — neuromuscular autoimmunity and impaired antiviral interferon…
Studies
Liver Endothelial Cells Clear Gold Nanoparticles Via Exosome Secretion Pathway
For anyone tracking the trajectory of nanomedicine toward clinical reality, the bottleneck has rarely been efficacy in…
Longevity
PDS5B Protein Decline Drives Chromosomal Errors in Aging Oocytes
Chromosomal errors in eggs from older mothers remain one of reproductive medicine's most consequential unsolved…
Studies
X-Linked SYTL4 Mutation Disrupts Presynaptic Vesicle Release in Autism
Understanding why certain genetic mutations produce autism spectrum disorder has long been hampered by incomplete maps…
Studies
Guanylate Kinase 1 Drives Inosine RNA Incorporation When ITPA Is Absent
A rare but severe childhood epilepsy syndrome may have just revealed a hidden enzymatic vulnerability in RNA quality…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.