Studies
Genicular Artery Embolization Targets Knee OA's Inflammatory Neovascularization Cycle
For the roughly 650 million adults worldwide living with knee osteoarthritis, the therapeutic gap between cortisone…
Longevity
Insulin Resistance Associated with Worse Cognition in Alzheimer's Independently of Amyloid Pathology
For anyone managing metabolic health with an eye toward brain aging, this finding reframes insulin resistance not…
Longevity
Gene Therapy's Expanding Role in Targeting Core Aging Mechanisms
For decades, aging has been treated as an inevitable backdrop to disease rather than a modifiable biological process…
Fitness
NOX4 Enzyme Decline Links Muscle Aging to Whole-Body Metabolic Collapse
For decades, reactive oxygen species have been cast as villains in aging — but this framing may be critically…
Studies
Urate-AMPK Pathway Offers Vasopressin-Independent Route to Reduce Polycystic Kidney Polyuria
For the millions living with autosomal dominant polycystic kidney disease (ADPKD), the gold-standard drug tolvaptan…
Studies
Oligonucleotide Therapy Targets Mitochondrial Failure in ALS Motor Neurons
For the millions living with or at risk of amyotrophic lateral sclerosis, the absence of disease-modifying treatments…
Nutrition
Common Food Preservatives Linked to 16–29% Higher Cardiovascular Risk
For decades, food preservatives have been evaluated primarily for cancer risk, but their cardiovascular implications…
Nutrition
Enzyme Concentration Unlocks Texture and Protein Digestibility in Plant Meats
For the roughly one-third of global consumers actively reducing animal protein intake, the biggest barrier isn't…
PREPRINTLongevity
Depression Outranks Grip Strength in Predicting Disability After 3+ Cardiometabolic Diseases
A predictive model built from China Health and Retirement Longitudinal Study (CHARLS) data using LASSO regression…
PREPRINTLongevity
ML Model Flags Advanced Chronic Illness with 91% Sensitivity Using 10 Clinical Variables
A machine learning pipeline trained on electronic health records from 163 patients at Hospital Universitario Parc…
PREPRINTLongevity
Deep-Learning Frailty Index Predicts 7x Mortality Risk Across Adults 35–103
A deep-learning-augmented electronic frailty index (eFI) built from 193,629 Finnish health records spanning ages…
PREPRINTSupplements
Ashwagandha vs. Boswellia RCT Tests 45-Day Knee OA Pain Relief in Over-60s
A registered double-blind RCT is enrolling 72 adults over age 60 with chronic knee osteoarthritis (pain ≥4 on…
PREPRINTLongevity
New 3-Domain Motivation Scale Maps Motivational Domains Across Ages 18–80, with Implications for Neurodegenerative Risk
A newly developed instrument called MotDem, co-designed with dementia patients, carers, and clinicians, identifies…
Wellbeing
Eight-Week Telehealth Mindfulness Program Cuts Chronic Back Pain in Primary Care Trial
Chronic low back pain consumes more healthcare dollars and generates more disability than almost any other…
Fitness
Eight Weeks of Swimming Restores Cardiac Mitochondrial Gene Signaling in Aged Rats
Cardiac aging is not simply inevitable deterioration — it may be partially reversible at the molecular level. For…
Wellbeing
Spontaneous Personal Memory Recall Measurably Deepens Emotional Response to Abstract Art
The intersection of memory and emotional wellbeing runs deeper than most people assume. New experimental evidence…
Studies
Smoking Accelerates Atherosclerosis Via Neutrophil Alarmins Bypassing Lung Damage
For decades, smoking's cardiovascular harm has been attributed largely to lung inflammation spilling over into…
Studies
Bourbon and Heartland Tick Viruses Confirmed in New York for First Time
Most people who develop a fever after a tick bite assume Lyme disease until proven otherwise — but two emerging…
Wellbeing
Brain Age in Anxiety Disorder Shows Variability, Not Uniform Acceleration
The assumption that anxiety disorders uniformly accelerate brain aging may need revision. For the millions of adults…
Studies
Teledermatology Matches In-Person Eczema Care While Cutting Patient Wait Times
For the millions of adults and children living with atopic dermatitis — a chronic, often debilitating skin condition…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.