Longevity
Cellular Vesicles Drive Arterial Plaque Formation Through Multi-Stage Communication Networks
Cardiovascular disease remains the leading cause of death globally, yet the intricate cellular communication driving…
Wellbeing
Dopamine Agonist Shows Promise for Depression-Related Pleasure Loss
The inability to experience pleasure represents one of depression's most debilitating symptoms, often persisting even…
Studies
TB Bacteria Create Protected Niches That Harbor Secondary Infections
Tuberculosis may be creating the perfect storm for additional infections by fundamentally reshaping the body's immune…
Longevity
Mathematical Model Identifies Two Distinct Aging Patterns Across Animal Species
Understanding why a mouse lives 2 years while a whale can reach 200 fundamentally shapes how we interpret aging…
Studies
Heated Tobacco Products Reach 48.9 Million Users Globally by 2024
The rapid global expansion of heated tobacco products represents a significant shift in nicotine consumption patterns…
Studies
MASH Prevalence and Costs Projected to Rise Sharply by 2040 Across Nine Countries
The silent epidemic of fatty liver disease is about to extract an unprecedented economic toll on healthcare systems…
PREPRINTStudies
Sierra Leone Heart Failure Study Shows 53-Year Median Age, 61% Reduced Ejection
A retrospective analysis of 765 hospitalized heart failure patients in Sierra Leone revealed a median age of just 53…
PREPRINTWellbeing
HIV Linked to Nearly Double Risk of Undiagnosed HFpEF in South African Women on ART
A comprehensive study of 1,508 South Africans found that women living with HIV on antiretroviral therapy face nearly…
PREPRINTStudies
ECG-Derived Age Acceleration Predicts Death Risk Using 10M-Recording Model
A foundation AI model trained on over 10 million ECG recordings successfully identified cardiovascular disease risk by…
PREPRINTStudies
Preoperative Immune Markers Predict 24% Recovery Variance After Knee Surgery
Researchers analyzed 45 immune biomarkers in 152 adults aged 60+ undergoing knee replacement surgery, finding that…
PREPRINTWellbeing
Opioid Use in 85+ Adults Reveals Complex Pain Management Balancing Act
Semi-structured interviews with 36 participants—including adults aged 85+, caregivers, and healthcare…
Nutrition
Higher DASH Diet Adherence Linked to 15% Lower CVD Risk in 83,248 Hypertensive UK Biobank Adults
Analysis of 83,248 UK Biobank participants with hypertension revealed that the DASH diet provided the strongest…
Longevity
Telomere Length Fails to Explain Race-Based Mortality Gaps in 6,526 Adults
Among 6,526 U.S. adults tracked over two decades, telomere length—widely regarded as a cellular aging biomarker—did…
Longevity
Flavonoid Corylin Extends Female Mice Lifespan 11.9% via mTOR Suppression
Corylin, a flavonoid from Psoralea corylifolia, extended median lifespan by 11.9% in female mice when administered…
Studies
PTPA Loss Correlates with Mesothelioma Resistance in 26% of Patients; Restoration in Cells Boosts Senescence and Chemo Sensitivity
PTPA gene loss occurs in 26% of malignant pleural mesothelioma patients and correlates with significantly decreased…
Longevity
Engineered Klotho mRNA Reverses Cellular Aging in 24 Hours
A single dose of engineered Klotho mRNA delivered via specialized nanoparticles restored youthful cellular function…
Studies
Radiation Therapy Triggers Cellular Senescence Driving Cancer-Related Lymphedema Progression
Radiation therapy induces cellular senescence in lymphatic endothelial cells, triggering increased expression of…
Studies
Chemotherapy-induced senescence cells predict poor survival in leukemia patients
Chemotherapy treatment in 128 acute myeloid leukemia patients significantly increased senescent cells expressing…
Longevity
Niclosamide Targets Multiple Inflammatory Pathways in Cellular Aging Models: In Vitro Evidence for Six Mechanisms
Niclosamide demonstrates six interconnected mechanisms that address inflammaging—the chronic low-grade inflammation…
Nutrition
Online Plant-Based Program Shows Trend Toward 16% Reduction in Estimated Diabetes Cardiovascular Risk in 12-Week Trial
People with type 2 diabetes face dramatically elevated cardiovascular disease risk, making dietary interventions that…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.