PREPRINTLongevity
17,964 Shared Genetic Variants Link Heart and Lung Disease Risk
A comprehensive genetic analysis identified 17,964 pleiotropic SNPs shared between major cardiovascular diseases and re…
Wellbeing
Virtual Palliative Care Program Shows Promise for Early Dementia Patients
The timing of palliative care intervention in dementia has long presented a clinical paradox: introduce it too late, an…
Studies
E-Cigarette Compounds Disrupt Heart's Electrical System Beyond Nicotine Effects
The assumption that e-cigarettes pose minimal cardiovascular risk is facing serious scientific challenge. Beyond the we…
Wellbeing
Male and Female Chronic Pain Involve Largely Distinct Biological Pathways
The assumption that chronic pain works the same way in everyone is cracking under mounting evidence that men and women…
Longevity
Post-Transcriptional Controls May Fine-Tune Fat Cell Energy Burning
The battle against excess body fat may hinge on molecular switches that operate beyond conventional gene activation pat…
Studies
Shape-Memory Hydrogel Patch Contracts Diabetic Wounds Using Light Activation
Diabetic wound care has long struggled with a fundamental problem: these chronic injuries lack the natural contraction…
Wellbeing
CPAP Therapy Reduces Daily Function Decline in Post-Stroke Patients
Stroke survivors face a complex recovery journey where sleep disorders can silently undermine their regained independen…
Studies
Brain Inflammation Triggers Novel Cell Death Pathway via MIF Nuclease
Progressive neurodegeneration in conditions like multiple sclerosis may finally have a clearer molecular target. Despit…
Wellbeing
Loneliness Plus Social Isolation Linked to Multiplied Risk of Severe Subjective Cognitive Decline in Perimenopausal Women
The interplay between social disconnection and cognitive function during perimenopause reveals a concerning multiplicat…
Studies
Brain Scans Predict Eye Movements During Movie Watching Without Cameras
Eye tracking technology could become obsolete for many neuroscience studies, as researchers demonstrate they can predic…
Studies
Bariatric Surgery Delivers 18% Greater Weight Loss Than GLP-1 Drugs
Metabolic bariatric surgery achieved 18.15% greater total weight loss than GLP-1 receptor agonist medications across fi…
Longevity
Sleep Disorders Affect Substantial Portions of Adults Over 65, Associated With Accelerated Cognitive Decline
Age-related sleep deterioration affects substantial portions of older populations, with insomnia occurring in 20-40% an…
Longevity
Four Biological Aging Markers Predict 20-Year Mortality in 4,000 Older Adults
Four biological aging markers tracked over 18.25 years in 4,000 Hong Kong adults (mean age 72.5) revealed distinct mort…
Longevity
Cellular Senescence Drives Oral Aging, Bone Loss, Cancer Risk
Cellular senescence—when cells stop dividing but resist death—creates a double-edged sword in oral health. These zombie…
Longevity
Food and Environmental Genotoxins Trigger Cellular Senescence via DNA Damage, Potentially Contributing to Aging
Daily exposures to genotoxins in tobacco, processed foods, and environmental pollutants—including N-nitroso compounds,…
Longevity
Epigenetic Clock Acceleration Rate Predicts Death Risk Over 24 Years
Analysis of 699 adults followed for 24 years revealed that the rate of epigenetic clock acceleration—how quickly DNA me…
Studies
AI Models Show Up to 100% Accuracy in Detecting Periodontal Bone Loss: Systematic Review Finds Wide Performance Range
Traditional periodontal disease diagnosis relies heavily on subjective clinical examination and manual interpretation o…
Studies
Respiratory Infections Kill 2.5 Million Annually Despite Three Decades of Medical Progress
The persistence of respiratory infections as humanity's deadliest infectious threat exposes a stark reality: despite re…
Wellbeing
Pesticide Exposure Near Farms Doubles Risk of Low Newborn Apgar Scores
Living near agricultural areas during pregnancy appears to compromise newborn health in measurable ways, with implicati…
Longevity
Machine Learning Identifies Personalized Anti-Inflammatory Interventions for Older Adults
Machine learning analysis of 287 older adults (mean age 77.6) revealed that personalized selection of anti-inflammatory…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.