Longevity
SOD1 Oxidation May Trigger Self-Amplifying Proteostasis Collapse in Aging Skin
Skin aging has long been attributed to cumulative oxidative damage, but a newly synthesized framework shifts the focus…
Longevity
Liver-Muscle Lactate Failure Identified as Core Driver of Age-Related Muscle Loss
Muscle wasting in aging has long resisted a unified mechanistic explanation, leaving clinicians without a clear…
Studies
Ambient AI Scribes Cut Emergency Physician Documentation Time by 73 Seconds
Clinician burnout is reshaping emergency medicine in ways that compromise both provider wellbeing and patient care…
Wellbeing
EEG-Based CNN Classifies Anxiety States With 95% Benchmark Accuracy
Real-time, objective anxiety detection has long been a gap in mental health care, where diagnosis depends almost…
Longevity
Sarcopenia Raises Dementia Risk 42%; Late-Life Obesity Shows Protective Effect
The relationship between body composition and dementia risk is far more nuanced than the conventional 'obesity is bad'…
Studies
Global Measles Infections Surpass 11 Million in 2024, Exceeding Pre-Pandemic Levels
When a vaccine-preventable disease that was once considered eliminated begins resurging at pandemic-era scale, it…
Studies
Galleri Multi-Cancer Blood Test Misses Key Stage-Reduction Endpoint in UK Trial
The promise of a single blood draw detecting dozens of cancers simultaneously has captivated oncologists and patients…
Studies
EBV-Targeted CAR-T and Vaccine Strategies Reframe Multiple Sclerosis Treatment
For decades, multiple sclerosis was treated almost exclusively as an autoimmune disease of unknown origin. The…
PREPRINTLongevity
MENA Men's Obesity Surges 3.5%/Year While Women's Cholesterol Improves: 16-Nation Gap
Across 16 Middle East and North Africa countries, cardiometabolic risk trajectories in young adults are splitting…
PREPRINTLongevity
Aortic Root Dilation Drives LV Dysfunction in 521 Tetralogy of Fallot Adults
In a retrospective longitudinal analysis of 521 adults with repaired tetralogy of Fallot (ToF) — spanning 1,053…
PREPRINTLongevity
82,999 Census Tracts Mapped: Only 4,765 Ready for Digital Heart Care
Across 82,999 US census tracts, nearly 50,000 lack adequate cardiologist access — yet a granular new analysis finds…
PREPRINTStudies
10-Variable XGBoost Model Beats Established Heart Failure Scores by 15% AUC
An XGBoost gradient-boosted model trained on 9,050 hospitalized heart failure patients across eight Singapore…
PREPRINTLongevity
ECG Atrial Markers Double CVD Death Risk When Combined With Metabolic Burden
Among 7,083 adults free of baseline cardiovascular disease, electrocardiographic markers of atrial cardiomyopathy…
Studies
Combined Osimertinib and Radiation Doubles CNS Control in EGFR-Mutant Lung Cancer
Brain metastases represent one of the most feared complications in lung cancer — they erode cognition, independence…
Studies
Anorectal STIs Rise Globally as Resistance and Asymptomatic Spread Complicate Control
Silent infections that evade both symptoms and immune detection are reshaping the global burden of bacterial sexually…
Studies
GLP-1 Weight Loss and Nausea Share One Brain Circuit, Blocking Separation
Silencing or restoring GLP-1 receptor (GLP1R) signaling in discrete brainstem neuron populations reveals a critical…
Studies
MC4R Agonist Setmelanotide Cuts BBS Albuminuria and Liver Stiffness Beyond Weight Loss
In a 37-year-old male with genetically confirmed Bardet-Biedl Syndrome (BBS10 compound heterozygous variants)…
Supplements
Resveratrol Disrupts Klebsiella Quorum Sensing, Cuts Dual-Species Biofilm by 55%
Resveratrol, quercetin, and epigallocatechin gallate (EGCG) were computationally screened against LuxS — a key enzyme…
Longevity
Planetary Health Diet Reshapes Gut Microbiome to Extend Human Healthspan
A narrative review from Semmelweis University synthesizes cross-disciplinary evidence positioning the gut microbiome…
Longevity
Dog Gut Microbiomes Mirror Human Aging Patterns Across Shared Disease Pathways
Dogs share overlapping gut microbial taxonomy, gene content, and functional pathways with humans — a similarity shaped…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.