Studies
MondoA Protein Coordinates Cancer Cell Metabolism Under Stress Conditions
Understanding how cancer cells adapt their metabolism during stress could unlock new therapeutic vulnerabilities, parti…
Studies
Two Host Proteins Enable Hepatitis E Virus Replication in Human Cells
The discovery of cellular machinery that hepatitis E virus hijacks for its own reproduction could unlock new therapeuti…
Studies
DNA Methylation Pattern Controls Pathogen Strength in Roundworm Studies
Understanding how pathogens regulate their destructive capabilities could revolutionize approaches to infectious diseas…
Longevity
Gas-Sensing Brain Cells Boost Mitochondrial Defense Against Metabolic Damage
The discovery that specialized neurons can chemically communicate with cellular powerhouses reveals a previously unknow…
Wellbeing
PARP7 Enzyme Guards Lung Barriers Against Environmental Toxins
Environmental toxins constantly assault our respiratory system, yet some individuals maintain healthier lungs despite s…
Studies
Lipid PI(4,5)P2 Controls Cellular Migration Through Arl4D GTPase Clustering
Cellular migration—fundamental to wound healing, immune responses, and unfortunately cancer metastasis—depends on preci…
Studies
Heme-DNA Complexes Amplify Lupus Inflammation Through Novel Oxidative Pathway
The destructive cycle of autoimmune disease may have a previously unrecognized amplifier. When red blood cells break do…
Studies
Med14 Protein Controls How Cells Respond to Diabetes Drugs
The cellular machinery governing how diabetes medications like Ozempic activate beneficial gene programs has remained l…
Wellbeing
PNAS News Feature Explores Neural Mechanisms Behind Acupuncture's Pain Relief Effects
Pain management stands at a crossroads where ancient wisdom meets modern neuroscience, with millions seeking alternativ…
Studies
High-Dose Rifampin Fails to Reduce Tuberculous Meningitis Mortality
Tuberculous meningitis remains one of medicine's most devastating infections, claiming nearly half of patients despite…
Studies
Semaglutide Lowers Blood Pressure Through Vascular Smooth Muscle Cells
Semaglutide reduces blood pressure through direct action on GLP-1 receptors in vascular smooth muscle cells (VSMCs), no…
Wellbeing
Inclined Sleepers Linked to 158 Infant Deaths Despite 2019 Safety Recalls
The persistence of preventable infant deaths highlights a critical gap between regulatory action and real-world safety…
PREPRINTStudies
Aficamten Improves Exercise Capacity in 60% of Hypertrophic Cardiomyopathy Patients
Pooled analysis of 457 patients with obstructive hypertrophic cardiomyopathy established that a 0.35 mL/kg/min increase…
PREPRINTWellbeing
Malnutrition Associated with up to 7-Fold Higher Death Risk in Children with Rheumatic Heart Disease
A two-year study of 118 Malawian children with rheumatic heart disease found that malnutrition dramatically increases m…
PREPRINTLongevity
5 Protein Markers Identify 10 Hypertension Subtypes with Varying Complication Risks
Machine learning analysis of 2,911 proteins in 7,086 UK Biobank hypertension patients identified 10 distinct clusters b…
PREPRINTStudies
Heart Failure Quality Program Associated With 3-5% Lower Mortality in Medicare Patients
Hospital participation in the Get With The Guidelines-Heart Failure program was associated with a 0.15-point increase i…
PREPRINTWellbeing
Childhood Cancer Treatment Impairs Endothelial Repair Through Senescent Cell Accumulation
Researchers tracked endothelial injury markers in 48 children with leukemia and lymphoma receiving anthracycline chemot…
PREPRINTStudies
Blood Pressure Variability Improves CVD Risk Prediction (C-Index from 0.716 to 0.833-0.837)
Blood pressure variability between medical visits dramatically outperformed single readings in predicting cardiovascula…
PREPRINTStudies
Myocarditis Ventricular Arrhythmias Increase Death Risk 5.5-Fold in US Hospitals
Among 17,845 US hospitalizations for acute myocarditis between 2016-2019, ventricular arrhythmias occurred in 8.4% of p…
PREPRINTStudies
Five Blood Pressure Readings Identify Cardiovascular Risk Thresholds
Analysis of 3,022 primary care patients established that five blood pressure measurements can reliably detect visit-to-…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.