PREPRINTStudies
LASr + LGE-CMR Combo Hits 91% AUC for AF Detection in Mitral Regurgitation
In 46 patients with moderate-to-severe degenerative mitral regurgitation (DMR), integrating left atrial reservoir…
PREPRINTLongevity
Stress Leaves 841 DNA Methylation Marks That Predict Heart Disease 17 Years Later
An epigenome-wide association study of 3,857 postmenopausal women in the Women's Health Initiative identified 841…
Wellbeing
Pregnancy Complications Linked to Higher Depression, Anxiety, and PTSD Risk
Mental health conditions now rank among the leading drivers of maternal death in the United States, yet the women at…
Longevity
Semaglutide Requires AgRP Neurons—Not Suppression—for Female Weight Loss in Mice (Preprint)
Contrary to the longstanding assumption that GLP-1 receptor agonists like semaglutide work by suppressing hypothalamic…
Studies
Senescent Glioma Cells Deploy SASP to Hijack Tumor Microenvironment, Fuel Recurrence
Cellular senescence in glioblastoma (WHO Grade IV) is not the tumor-suppressive endpoint it represents in normal…
Wellbeing
Strong Family Bonds and School Recognition Linked to Lower Teen Suicide Risk in Study of Over 190,000 Pennsylvania Students
Teen suicide prevention has long concentrated on reducing individual risk factors — depression, substance use…
Studies
ER Injuries Linked to 34–98% Higher Mental Health Diagnosis Risk Within One Year
Most conversations about injury care focus on physical recovery — broken bones, wound healing, rehabilitation. But the…
Fitness
Visual Biofeedback During ACL Training Reshapes Brain Activity in Teen Athletes
Anterior cruciate ligament tears disproportionately strike adolescent female athletes, and a substantial portion of…
Studies
Chimeric Protein Strategy Restores SOX17 Tumor Suppressor in Bile Duct Cancer Cells
Cholangiocarcinoma — bile duct cancer — carries one of the bleakest prognoses in oncology, with five-year survival…
Supplements
Ginkgo Biloba's Cardiovascular Mechanisms Mapped in Comprehensive Pharmacological Review
For adults seeking evidence-based approaches to cardiovascular protection, understanding exactly how botanical…
Studies
FOSL1-KCa3.1 Axis Links Mitochondrial Hyperfusion to Cartilage-Destroying Ferroptosis
Osteoarthritis affects hundreds of millions of adults globally, yet disease-modifying treatments remain elusive. Most…
Studies
9-mg Mazdutide Achieves Significant Weight Reduction in Chinese Obesity Trial
The global obesity epidemic rarely receives tailored pharmacological solutions for specific populations, yet metabolic…
Studies
Oral GLP-1 Pill Plus Insulin Cuts HbA1c Beyond Insulin Alone
For the roughly half of insulin-treated type 2 diabetes patients who never reach their glycemic targets, the prospect…
Studies
Oral GLP-1 Agonist Plus Insulin Cuts HbA1c Beyond Insulin Alone
For the roughly one-third of people with type 2 diabetes who remain poorly controlled despite daily insulin…
Studies
Oral GLP-1 Pill and Dual Agonist Show Promising Weight-Loss Efficacy in New Trials
The dominance of injectable GLP-1 medications may soon face a genuine challenge from oral and multi-receptor…
Studies
Self-Directed CBT Outperforms Clinician-Delivered Care for Chronic Pain Interference Reduction
Chronic pain affects roughly one in five adults globally, and access to trained cognitive behavioral therapy…
Studies
Self-Directed CBT Matches Clinician-Led Therapy for Chronic Pain Relief
Chronic pain affects roughly one in five adults globally, yet access to skilled cognitive behavioral therapists…
Studies
Web-Based Decision Tool Cuts Antidepressant Discontinuation at Eight Weeks
Antidepressant adherence is one of the most persistent challenges in depression management — roughly half of patients…
Studies
Secret Shopper Study Exposes Clinical Gaps in Online GLP-1 Prescribing
The rapid proliferation of telehealth platforms offering weight-loss medications has outpaced regulatory oversight…
Studies
Pre-diagnosis POP Blood Levels Show Mixed ALS Risk Signals Across Europe
Amyotrophic lateral sclerosis remains one of the most devastating neurodegenerative diseases, with no cure and poorly…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.