PREPRINTLongevity
FAXAge Trial Tests Exercise Plus Fasting on DNA Aging in 240 Seniors
The FAXAge trial will randomize 240 healthy adults over 65 into four groups—exercise alone, time-restricted feeding alo…
PREPRINTWellbeing
Under-Mattress Sensors Predict Next-Day Dementia Agitation Episodes
Contactless under-mattress sensors successfully predicted next-day agitation episodes in dementia patients across 73 in…
Longevity
Y Chromosome Loss in Men Elevates Type 2 Diabetes Risk
Age-related cellular changes may fundamentally alter how we assess diabetes susceptibility in men. While genetic risk s…
Studies
Novel Compound HJ03 Triggers Dual Cell Death Pathways Against Resistant Brain Tumors
Drug-resistant glioblastoma represents one of oncology's most formidable challenges, with patients facing median surviv…
Supplements
Muscle-Preserving Antibody Boosts GLP-1 Weight Loss by 25 Percent
The obesity treatment landscape may be approaching a critical inflection point where preserving muscle mass becomes as…
Fitness
Muscle Vesicles Carry miR-378a-3p to Brain, Clearing Alzheimer's Plaques
The mechanism behind exercise's protective effect against cognitive decline may finally have a molecular messenger. New…
Longevity
DNA Methylation Clock Outperforms Existing Biomarkers in Mortality Prediction
Healthcare systems worldwide are sitting on vast troves of patient data that could revolutionize how we measure biologi…
Studies
DNA Origami Platforms Target Gynecological Cancers With Programmable Precision
Women facing ovarian, cervical, and endometrial cancers may soon benefit from a fundamentally different therapeutic app…
Wellbeing
Meta-Analysis of 51 Studies: Time-Restricted Feeding Linked to Shorter Self-Reported Sleep and Worse Quality, Especially During Ramadan
The growing popularity of intermittent fasting approaches may come with an unexpected cost to sleep quality and duratio…
Studies
Blood Test Tracks Brain Gene Expression in Living Primates
A breakthrough in neuroscience methodology could transform how researchers study brain function and test gene therapies…
Studies
Methioninase-Cisplatin-Ivermectin Triple Combination Selectively Destroys Lung Cancer Cells
Cancer's reliance on methionine—an essential amino acid—may represent an Achilles' heel that researchers can exploit wi…
Studies
AI Brain Age Analysis Predicts Stroke Recurrence Risk Better Than Chronological Age
The biological age of your brain tissue may be a more powerful predictor of future strokes than your actual age, offeri…
Studies
Tophat Laser Profile Doubles Bone Cutting Depth for Surgical Applications
Precision bone surgery could become dramatically more viable as researchers demonstrate how laser beam geometry fundame…
Longevity
Genetic Analysis Links Brain Atrophy Patterns to Metabolic Dysfunction in Alzheimer's
The intricate relationship between metabolism and brain health takes on new significance as genetic evidence emerges li…
Longevity
Depression Accelerates Biological Aging Through Shortened Telomeres, Mendelian Analysis Shows
Mendelian randomization analysis of global health data reveals depression causally accelerates biological aging through…
Longevity
Eleutheroside B Activates Autophagy, Reduces Alzheimer's Proteins in Worms
Eleutheroside B, a compound from Siberian ginseng, dramatically reduced amyloid-beta and tau protein accumulation while…
Longevity
AXIN-LKB1 Complex Creates Glucose-Sensing Pathway Controlling Lifespan Extension
Lin's research reveals a sophisticated glucose-sensing mechanism where the AXIN:LKB1 complex translocates to lysosomal…
Longevity
Aspartame Activates Autophagy Pathway, Extends Lifespan 100μM C. elegans
Aspartame at 100 μM concentrations activated autophagy genes (bec-1, unc-51, lgg-1, lgg-2, atg-5) in C. elegans worms,…
Studies
Triple-Action Nanoparticles Overcome Cancer's Oxidative Stress Resistance Through Targeted Enzyme Disruption
Cancer cells have evolved sophisticated defense mechanisms against oxidative stress therapies, often rendering promisin…
Studies
Zanubrutinib Shows 70% Five-Year Progression-Free Survival in High-Risk Leukemia
Patients with chronic lymphocytic leukemia carrying specific genetic mutations have historically faced grim outcomes, w…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.