Studies
RERUN Trial Tracks Real-World T-DXd Outcomes in Chinese HER2-Mutant Lung Cancer
As antibody-drug conjugates reshape the oncology landscape, a critical gap remains between clinical trial populations…
Studies
Lipid Nanoparticles Breach Cell Interior to Deliver Full Antibodies Against Cancer and Parkinson's
One of the fundamental constraints in modern medicine is that therapeutic antibodies — among the most precise…
Studies
Tirzepatide vs Semaglutide: Equal Asthma Exacerbation Risk, but Tirzepatide Cuts Rescue Inhaler Use 8%
Among 16,352 propensity-score-matched adults with comorbid asthma and type 2 diabetes, tirzepatide (a dual GIP/GLP-1…
Studies
GLP-1 Drugs Consistently Strip Lean Mass: Meta-Analysis of 1.25M Patients
Across 60 studies encompassing 1,250,717 individuals — including 46 randomized controlled trials — GLP-1 receptor…
Longevity
DHM Clears NLRP3 Inflammasome via Autophagy, Reversing AD-Like Cognitive Decline
Dihydromyricetin (DHM), a flavonoid found in Ampelopsis grossedentata, reversed spatial learning and memory deficits…
Studies
Insulin Resistance Plus Frailty Synergistically Amplify Cardiovascular Risk Across 260,000 Adults
For adults managing metabolic risk, knowing that two common clinical markers interact to compound cardiovascular…
Studies
3D Genome Reorganization Identified as Core Molecular Feature of Alzheimer's Disease
Understanding why certain brain cells deteriorate in Alzheimer's while others remain resilient has been one of…
Studies
3D Genome Architecture Emerges as Key Driver of Alzheimer's Cell Dysfunction
Most Alzheimer's research has focused on amyloid plaques, tau tangles, and neuroinflammation — but a fundamental layer…
Studies
Novel ADC Pelitecan Shows Survival Benefit in Relapsed Small-Cell Lung Cancer
Small-cell lung cancer carries one of oncology's bleakest prognoses precisely because it responds well to initial…
Studies
Multimodal Explainable AI Outperforms Standard Biomarkers for Lung Cancer Immunotherapy Decisions
Predicting which lung cancer patients will respond to immunotherapy remains one of oncology's most consequential…
Studies
Multimodal Biomarker Integration Sharpens Cancer Immunotherapy Response Prediction
Predicting which cancer patients will actually respond to immunotherapy remains one of oncology's most pressing…
Wellbeing
Optogenetic Brain Stimulation Mimics Sleep's Synaptic Reset During Wakefulness
The assumption that the restorative power of sleep is inseparable from sleep itself may be fundamentally wrong. A…
Studies
Alzheimer's Prevention Gap Rooted in Provider Guidance Deficit, Not Disinterest
Nearly half of all Alzheimer's disease cases may be preventable, yet the United States has been remarkably slow to…
PREPRINTLongevity
Cardiac Myosin Inhibitors Boost Exercise Capacity 29% in Non-Obstructive HCM
Pooling three randomized controlled trials — MAVERICK-HCM, ODYSSEY-HCM, and ACACIA-HCM — across 1,156 adults with…
PREPRINTStudies
India's 300-Person SPC Trial Tests Early Combination Pills vs. Usual Hypertension Care
A pragmatic, multicentre randomized trial enrolling 300 Indian adults with untreated or undertreated hypertension has…
PREPRINTStudies
Nepal's Rural RHD Rate 6x Higher Than Kathmandu, Zero Decline in 30 Years
Pooled analysis of ten echocardiography-confirmed studies across Nepal — encompassing 209,815 participants and 5,440…
PREPRINTStudies
1-in-5 Nepalese Adults Have Metabolic Syndrome, But True Rate Could Be 2–79%
Pooling eight observational studies covering 21,708 Nepalese adults, this systematic review estimates metabolic…
PREPRINTStudies
Kratom and Ibogaine Show Alarming Cardiac Arrhythmia Signals in 18.5M FDA Reports
Across 18,499,626 FDA Adverse Event Reporting System cases from 2000–2024, two psychoactive substances stand out for…
Studies
GLP-1 Receptor Agonists Linked to Elevated Alopecia Risk Versus Rival Diabetes Drugs
As GLP-1 receptor agonists like semaglutide and tirzepatide reach tens of millions of users globally, questions about…
Studies
Maresin 1 Lipid Mediator Shrinks Jaw Bone Lesions via Immune Regulation
Chronic dental infections that quietly destroy jawbone affect hundreds of millions of people globally, yet treatment…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.