PREPRINTLongevity
Large Clonal Hematopoiesis Associated with 28% Higher Death Risk in Older Women
Clonal hematopoiesis of indeterminate potential (CHIP) — age-related expansion of blood stem cells carrying preleukemic…
Studies
MET Inhibitor Savolitinib Shows Promise Against Amplified Gastric Cancers
Targeted cancer therapy takes another step forward with evidence that patients harboring specific genetic alterations i…
PREPRINTStudies
5-Slice CMR Protocol Maintains 90%+ Accuracy for Heart Function Assessment
A geometric modeling approach using just five cardiac MRI slices achieves over 90% concordance with full-stack imaging…
PREPRINTStudies
Ghanaian Adults Show 21.3% Multidomain Hypertension Damage, Rising to 44.4% After 60
A cross-sectional analysis of 1,106 Ghanaian adults revealed that 21.3% exhibited multidomain hypertension-mediated org…
PREPRINTStudies
AI-Automated Heart Strain Analysis Predicts Death Risk in 8,231 Patients
Researchers developed automated AI-based indices that integrate right atrial and ventricular strain measurements to ass…
PREPRINTWellbeing
New OFDI Technique Accurately Measures Coronary Plaque Lipid Content
Depolarization-sensitive optical frequency domain imaging (depOFDI) demonstrated strong correlation (r² = 0.862-0.867)…
Longevity
Embryonic Stem Cell Vesicles Reverse Chemotherapy-Induced Ovarian Aging
Extracellular vesicles from embryonic stem cells successfully reversed chemotherapy-induced ovarian failure in mice, re…
Studies
GLP-1 Drugs Plus Behavioral Therapy Boost Adolescent Treatment Adherence 18.5x
Adolescents receiving liraglutide alongside health behavior and lifestyle therapy showed an 18.5-fold increase in treat…
Supplements
Resveratrol Liposomes Restore Fertility After Chemotherapy Via HIGD1A Pathway
Resveratrol-loaded liposomes significantly protected ovarian function in mice exposed to cyclophosphamide chemotherapy…
Longevity
Early-Life Obesity in Rats Leaves Metabolic Memory via Gut Microbiome and GABA Changes That Accelerates Aging-Related Decline
Transient high-fat diet exposure during early development permanently altered aging trajectories in both rats and fruit…
Nutrition
Nitrate Fertilization Boosts Resveratrol Production and Enhances Plant Resistance to Fusarium Wilt via Beneficial Fungi
Nitrate fertilization dramatically reshapes the soil microbiome around cucumber roots, recruiting beneficial Funnelifor…
Supplements
Plant Compounds Curcumin, Resveratrol Target Cancer Stem Cell Pathways
Four plant compounds—curcumin, resveratrol, epigallocatechin gallate (EGCG), and genistein—demonstrate the ability to d…
Longevity
Gut Microbiota-mTOR Axis Drives Poor Vaccine Response in Aging
Declining gut microbial diversity and reduced short-chain fatty acid production in aging creates a destructive feedback…
Longevity
Spermidine Supplementation Reverses Immune Senescence, Boosts COVID Vaccine Response
Daily 6mg spermidine supplementation for 13 weeks reversed cellular aging markers in immune cells and significantly enh…
Longevity
Adaptogenic Herbal Formula ADAPT-232 Extends Lifespan via Mitochondrial Cleanup
ADAPT-232, a standardized blend of adaptogenic herbs, significantly extended lifespan in C. elegans while enhancing the…
Longevity
Gene Therapy Shows Multi-Organ Rejuvenation Potential Across Aging Systems
Gene therapy demonstrates efficacy across nervous, muscular, circulatory, and immune systems in preclinical aging model…
Longevity
Methionine Restriction Extends Yeast Lifespan via PP2A Methylation Inhibition
Methionine restriction extends yeast lifespan by reducing S-adenosylmethionine (SAM) production, which prevents methyla…
Studies
Dual-Target Compound Blocks Aggressive Breast Cancer Metastasis Pathways
Triple-negative breast cancer represents one of the most aggressive malignancies, with limited treatment options and hi…
Studies
Engineered Stem Cells Show Promise Against Deadliest Brain Cancer
Glioblastoma represents medicine's most formidable oncological challenge, with median survival rarely exceeding 15 mont…
Studies
Perspective: GLP-1 Medications Could Worsen Food Insecurity Challenges in the UK
The explosive popularity of GLP-1 receptor agonists like semaglutide and tirzepatide for weight management may be creat…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.