PREPRINTStudies
CABG Shows Mixed Benefits Over PCI in 103,670 High-Risk Cardiac Patients
Analysis of 103,670 high-risk cardiac patients requiring coronary revascularization found heterogeneous treatment…
Wellbeing
Abdominal Muscle Separation Linked to Multiple Pain Conditions in New Mothers
The physical toll of motherhood extends far beyond delivery, with new evidence revealing how abdominal muscle…
Studies
Contact Tracing Identifies TB Cases Without Highly Infectious Markers in 77% of Instances vs 39% for Symptom-Based Methods
Contact tracing emerges as a powerful early intervention tool that could reshape tuberculosis prevention strategies…
Studies
Mitochondrial Fusion Patterns Control Liver Cancer Cell Identity Switching
Combined hepatocellular-cholangiocarcinoma represents one of medicine's most puzzling malignancies—a single tumor that…
Studies
Engineered DARPins Restore Function to Temperature-Sensitive p53 Mutants Common in Half of Cancers
Cancer's most critical weakness may have found its match through protein engineering that could revolutionize…
Studies
Designer Protein Reverses Cancer-Driving Immune Receptor Mutation Through Structural Engineering
Cancer researchers have achieved a breakthrough that could reshape how we target immune system malignancies at their…
Studies
Novel Biosensor Reveals How Heart Failure Alters Norepinephrine Signaling Dynamics
Heart failure patients often struggle with exercise intolerance and fatigue, symptoms that may stem from disrupted…
Longevity
Brain's Waste-Clearing System Emerges as Actionable Target for Cognitive Aging
The prospect of slowing cognitive decline may hinge on a recently discovered brain maintenance system that operates…
Studies
Viral Protein M45 Forms Hybrid Structures with Human RIPK3 to Block Cell Death
Cell death pathways represent a critical battlefield where viruses and human immune defenses clash, with implications…
Studies
Specialized Astrocytes Shield Optic Nerve From Glaucoma-Related Damage
Vision loss from glaucoma may become more preventable as scientists identify protective brain cells that naturally…
Longevity
ATG9A Autophagy Protein Repairs Cell Membranes Through Glycosylation Control
Cell membrane integrity represents a critical threshold between healthy cellular function and death, making membrane…
Studies
Modular NIR-II Probe Advances Real-Time Cancer Surgery Visualization Beyond 1,300nm
Surgical precision during cancer removal could dramatically improve as imaging technology pushes deeper into the…
Wellbeing
Century-Long US Suicide Data Reveals Hidden Demographic Patterns
Mental health professionals have long recognized suicide as a critical public health challenge, but the complete…
Studies
Ancient Pottery Analysis Reveals Wine and Dairy Processing 5,000 Years Ago
Archaeological chemistry is revolutionizing our understanding of human dietary evolution, providing concrete evidence…
Wellbeing
Neural Circuit Plasticity May Explain Ketamine's Rapid Antidepressant Effects
Treatment-resistant depression affects millions who find no relief from conventional antidepressants, making…
Wellbeing
60% of Levothyroxine Prescriptions May Be Unnecessary Despite Lifelong Treatment
The thyroid medication landscape reveals a striking disconnect between prescription patterns and clinical necessity…
Studies
ApoB Targets Prove More Cost-Effective Than LDL Cholesterol Metrics
The way cardiologists measure cholesterol treatment success could fundamentally shift based on economic evidence…
Studies
Long-Term Opioid Use Patterns Reveal Persistent Public Health Challenge
The persistence of long-term opioid dependency represents one of the most significant barriers to healthy aging in…
Studies
New Guidelines Reshape Crohn's Disease Treatment Targeting Early Intervention
Inflammatory bowel disease affects millions worldwide, yet treatment approaches have historically focused on symptom…
Studies
ApoB Emerges as Superior Biomarker for Statin Treatment Intensification Decisions
The shift toward apolipoprotein B (apoB) as a primary treatment target could fundamentally change how millions of…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.