Studies
AI Scribes in Residency Training Risk Undermining Clinical Reasoning Development
As artificial intelligence reshapes the mechanics of clinical practice, its earliest and least-examined casualty may…
PREPRINTLongevity
Childhood Smoking Associated with 0.65 Years Accelerated GrimAge Decades Later
In 3,562 participants from the U.S. Health and Retirement Study (mean age 69.6 years), childhood smoking was…
PREPRINTStudies
Solanezumab's Amyloid Endpoint Fails Mediation Test in A4 Trial Analysis
Applying causal mediation analysis to the A4 trial — which tested solanezumab in cognitively unimpaired adults with…
PREPRINTStudies
BRCA1/2 Breast Cancer Survivors Show Lower CVD Rates—But Competing Risks Explain Why
Among 32 matched cohort pairs of breast cancer survivors in the Stockholm-Gotland region (2008–2019), women carrying…
PREPRINTLongevity
3-Domain Capacity Score Predicts 10-Year Mortality in 1,705 Men Over 70
A composite measure of intrinsic capacity — spanning cognition, locomotor function, psychological well-being, and…
PREPRINTStudies
5-Feature AI Model Identifies Type A Aortic Dissection Entry Tear with 97.6% Sensitivity but Only 17% Specificity in External Validation (Preprint)
An automated machine-learning model trained on preoperative CT angiography data correctly identified the primary entry…
Studies
Apelin Analog Reverses Pulmonary Hypertension and Right Heart Failure in Rat Model
Pulmonary arterial hypertension remains one of medicine's most stubborn vascular killers — progressive, difficult to…
Longevity
Cross-Species RNA Atlas Reveals Universal Molecular Clocks of Aging and Death
Understanding why some people age faster than others — and what interventions actually slow biological deterioration…
Longevity
Large-scale Plasma Proteomics Links Physical Activity to Proteins Associated with Dementia Risk
Across three cohorts totaling over 11,000 participants, plasma proteomics using the SomaScan 7k platform (measuring…
Studies
PEGylated Liposomal Resveratrol Reduces Select Brain ROS But Fails to Rescue ASD Behaviors in VPA Rat Model
A rat model of autism spectrum disorder (ASD), induced via prenatal valproic acid (VPA) exposure, received PEGylated…
Longevity
Narrative Review Maps IF Protocols to AMPK-mTOR-SIRT1 Pathways for Cardiometabolic Health
Four IF protocols — TRE (16/8), alternate-day fasting, 5:2, and OMAD — converge on a shared molecular architecture…
Longevity
Single-Cell Map Reveals Progressive Vascular Collapse Mechanism in Progeria
Understanding why children with Hutchinson-Gilford Progeria Syndrome invariably die of cardiovascular disease — and…
Studies
Study Maps Protective Niches Harboring Dormant Breast Cancer Cells Near Immune and Stromal Cells
Understanding why breast cancer returns years after apparent remission is one of oncology's most vexing problems. This…
Studies
MYC Phosphorylation at Serine 62 Drives DNA Repair in Cancer Cells
One of oncology's most persistent puzzles is how MYC — the transcription factor gone rogue in virtually every human…
Nutrition
Pulse- vs Meat-Protein Diets Show Similar Cardiometabolic Benefits in Older Adults, With Possible Ferritin Edge for Pulses
For older adults navigating the intersection of cardiovascular risk and metabolic aging, protein source may matter as…
Longevity
TRF2 Protein Controls Muscle Stem Cell Fate Beyond Telomere Protection
The capacity to rebuild damaged muscle tissue erodes with age and disease, making the molecular switches governing…
Studies
Focused Ultrasound Unlocks Blood-Brain Barrier for Precision Neurological Drug Delivery
For decades, the blood-brain barrier has been the single greatest pharmacological obstacle in neurology — a fortress…
Studies
Congo Basin Conflict Accelerates Zoonotic Spillover Across 15 Known Pathogens
Few regions on Earth concentrate as many converging health risks as the Congo Basin — and most of the world has been…
PREPRINTSupplements
Glucosamine's Alzheimer's Link May Reflect Supplement-User Bias, Not Causation
Reanalysis of a National Alzheimer's Coordinating Center cohort reveals that the association between documented…
PREPRINTLongevity
Blood p-tau 217 Predicts Alzheimer's 20 Years Early With 80% Accuracy
Brain-derived phosphorylated tau 217 (p-tau 217), measured in blood samples from 213 Alzheimer's cases and 213 matched…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.