Studies
Brexpiprazole Shows Enhanced Effect in Alzheimer's Agitation with Psychosis
The presence of psychotic symptoms in Alzheimer's patients may predict stronger therapeutic response to certain…
Supplements
Intranasal Resveratrol Shields Brain-Eye Axis From Cisplatin Chemotherapy Damage
Resveratrol administered through nasal passages protected brain and retinal tissues from cisplatin-induced damage in…
Longevity
Deuterated PUFAs Including Omega-3s Protect Muscle Cells from Oxidative Damage and Ferroptosis In Vitro
Deuterated polyunsaturated fatty acids—omega-3s and omega-6s with hydrogen atoms replaced by deuterium at vulnerable…
Longevity
Alzheimer's-Diabetes Microbiota Transplants Suppress Hippocampal Neurotrophic Gene Expression
Fecal microbiota transplants from elderly women with both Alzheimer's disease and type 2 diabetes produced the most…
Longevity
Antibiotic Enrofloxacin Accelerates Gut Aging Through Mitochondrial Damage
Chronic exposure to enrofloxacin, a veterinary antibiotic commonly found in environmental contamination, accelerates…
Nutrition
Mediterranean Diet Linked to 4% Lower Cancer Death Risk Across Multiple Cancer Types
A comprehensive meta-analysis of 17 studies spanning 8,314 records demonstrates that higher adherence to the…
Longevity
Telomerase Gene Therapy Reverses Heart Failure in Kidney Disease Models
Gene therapy targeting telomeres achieved remarkable cardiac recovery in mouse models of cardio-renal syndrome, where…
Studies
Esketamine Activates SIRT3/AMPK/mTOR Pathway to Prevent Post-Surgery Cognitive Decline
Esketamine, a derivative of the anesthetic ketamine, prevented postoperative cognitive dysfunction in aged mice by…
Longevity
Fisetin Senolytic Treatment Reverses Age-Related Endothelial Dysfunction Partially Via CXCL12 in Old Mice
Fisetin supplementation at 100 mg/kg daily reversed age-related blood vessel dysfunction in 27-month-old mice by…
Longevity
ADIOL Hormone Links Fasting Benefits to Neural Health via Kynurenine Pathway
Researchers identified 5-androstene-3β,17β-diol (ADIOL), a steroid hormone discovered nearly 100 years ago, as the…
Studies
Brain Cell Analysis Links 345 Genes to Six Mental Health Disorders
Mental health research has long struggled with a fundamental puzzle: how do thousands of genetic variants scattered…
Studies
Cystatin C Blood Marker Predicts Heart Failure Deaths Better in Reduced Ejection
Heart failure patients may soon have access to more precise prognostic tools through a simple blood test that measures…
Longevity
Brain Protein Cleanup Enzymes Decline With Age But Antioxidants Restore Function
The brain's ability to maintain proper protein function may deteriorate earlier in aging than previously recognized…
Studies
RNA-Based Therapies Show Promise for Genetically-Elevated Cardiovascular Risk Factor
Cardiovascular disease remains the world's leading killer despite decades of advances in cholesterol management…
Studies
Nine-Protein Blood Test Predicts Kidney Disease in APOL1 Carriers
Genetic predisposition to kidney disease just became more actionable. Adults carrying high-risk APOL1 gene…
Longevity
Global Fertility Rates Approach Replacement Threshold, Signaling Population Peak
The trajectory toward global population stabilization carries profound implications for aging societies and healthcare…
Studies
PCSK9 Gene Editing Shows Promise for Permanent Cholesterol Control
Permanent genetic modifications to lower cholesterol could revolutionize cardiovascular prevention, potentially…
Wellbeing
Review Positions CXCL13 as Key Hub in Multi-Organ Pathology of Obesity-Related Metabolic Inflammation
A critical immune signaling protein may explain why obesity triggers such widespread metabolic damage across multiple…
PREPRINTStudies
AI Model Identifies 29% More Cardiac Amyloidosis Cases Missed by Doctors
Researchers developed Amylo-Detect, a machine learning model that analyzes electronic health records to identify…
PREPRINTStudies
16.6% Medicare CLTI Patients Skip Vascular Imaging Before Major Amputation
Among 10,666 Medicare beneficiaries with chronic limb-threatening ischemia undergoing major lower-extremity…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.