PREPRINTFitness
Blue-Collar Workers Move More at Work, Less at Leisure: 2,809-Person Accelerometry Study
Accelerometry data from 2,809 adults in the Northern Finland Birth Cohort 1966 (46-year follow-up) reveals stark…
PREPRINTStudies
Protocol Registered for Study of Optimized Methadone/Buprenorphine Titration Schedules in Fentanyl Era
A protocol paper registered on medRxiv describes a planned population-based retrospective cohort study using linked…
PREPRINTNutrition
Stool DNA Sequencing Reveals Personal Food Profiles With 72% Participation Rate
The Everyone EATS pilot study demonstrated that stool-derived DNA sequencing can reconstruct individual diets at…
Longevity
IRF1 Activates PI3K/AKT to Drive Bone Stem Cell Osteogenesis, Reversing Osteoporosis
Overexpression of interferon regulatory factor 1 (IRF1) in murine bone marrow mesenchymal stem cells (mBMSCs) enhanced…
Supplements
New GLP-1 Drug TE-8105 Achieves 120-Hour Half-Life in Phase 1 Trial, Supporting Potential Biweekly Dosing
A phase 1 first-in-human trial of TE-8105 — a novel long-acting GLP-1 receptor agonist — tested four single ascending…
Longevity
Study Links Adverse Weather to Reversible Telomere Shortening in Dairy Goats
In 20 pluriparous Alpine dairy goats monitored across three 15-day intervals, acute environmental stress produced…
Longevity
Larger Social Networks Linked to Better Cognition in Older Men But Smaller Hippocampal Volume in Women
In 104 older adults (mean age 73.8; 60 female), greater social network size—measured via the Social Network Index—was…
Supplements
0.1 μM Resveratrol Fully Reverses Radiation-Induced Endothelial DNA Damage In Vitro
At a strikingly low concentration of 0.1 μM — far below typical supplementation doses — resveratrol completely rescued…
Studies
Ketamine and Psychedelics Share Immune Signaling Pathways Behind Rapid Antidepressant Effects
Treatment-resistant depression affects tens of millions worldwide, and the unexplained speed of ketamine's…
Longevity
Contracted 'Life Space' Associated with Cognitive Decline and Mortality Risk in Older Adults: Concept Analysis
How far an older adult ventures from home on a typical week turns out to be one of the most information-dense signals…
Studies
Three-Arm UK Trial Compares Compression Systems for Venous Leg Ulcer Healing
Venous leg ulcers affect roughly one percent of adults in high-income countries and consume disproportionate nursing…
Nutrition
Resveratrol + Tomato Pectin Synergy Rewires Gut-Liver Axis via FXR Signaling
Combining resveratrol (RSV) and tomato pectin (TP) in high-fat-diet mice produced synergistic metabolic benefits…
Supplements
Resveratrol Targets EGFR and PI3K-Akt to Block RSV in Silico
Computational screening of 261 resveratrol-associated targets against 1,196 RSV-related targets yielded 67 shared…
Supplements
Nitrate + Resveratrol Adds Liver-Specific Metabolic Gains Beyond Exercise Alone
In C57Bl/6N mice fed a high-fat diet for 6 weeks, aerobic exercise training (AET) alone reduced adipocyte size…
Longevity
5 Gut Fungi Genera Associated with Arterial Stiffness and Linked to Adrenergic/ACE Pathways in Observational Cohort
In a 763-participant cohort study using brachial-ankle pulse wave velocity measurement, ITS sequencing, and untargeted…
Nutrition
Mediterranean Diet Linked to Lower Risk Across 7 Cancer Types in Large Meta-Analysis
Across 126 studies enrolling more than 8 million participants, greater adherence to the Mediterranean diet was…
Nutrition
1.4M-Person Meta-Analysis Links Mediterranean Diet Adherence to 46–66% Lower Peripheral Artery Disease Risk
Across 87 studies encompassing over 1.4 million participants, higher Mediterranean diet (MD) adherence delivered…
Longevity
IL-8 and Exosomes Drive Senescence Spread in Rare Lung Disease via CXCR2
In an in vitro model of Lymphangioleiomyomatosis (LAM)—a rare destructive lung neoplasm—primary LAM/TSC cells lacking…
Studies
mTOR-Driven Glycogen Accumulation and Cellular Senescence Identified in All 13 Fibrofolliculomas
Every one of 13 archival fibrofolliculoma specimens displayed diastase-sensitive PAS-positive glycogen granules in…
Longevity
Immunosenescence Linked to SLE Pathogenesis via Senescent T Cells, Age-Associated B Cells, and SASP
SLE's peak incidence after age 48 masks a deeper truth: even young SLE patients exhibit accelerated immune aging…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.