Studies
mTOR-Driven Glycogen Accumulation and Cellular Senescence Identified in All 13 Fibrofolliculomas
Every one of 13 archival fibrofolliculoma specimens displayed diastase-sensitive PAS-positive glycogen granules in…
Longevity
Immunosenescence Linked to SLE Pathogenesis via Senescent T Cells, Age-Associated B Cells, and SASP
SLE's peak incidence after age 48 masks a deeper truth: even young SLE patients exhibit accelerated immune aging…
Fitness
β2-Microglobulin Mediates ~38% of the Association Between Physical Activity and Slower Epigenetic Aging
In a cross-sectional analysis of 936 U.S. adults paired with single-cell RNA sequencing in exercised mice, higher…
Wellbeing
AQP4 Gene Variant Modifies Association Between Short Sleep and Tau Burden Before Age 60
Whether genetic makeup determines who is most harmed by chronic short sleep—at least in terms of Alzheimer's-related…
Longevity
Lipid Metabolism Emerges as Central Driver of Alzheimer's Neuroinflammation
The long-standing focus on amyloid plaques and tau tangles as the primary targets in Alzheimer's research may be…
Studies
Ivermectin Periconception Exposure Shows No Clear Adverse Pregnancy Signal in African Trials
For the hundreds of millions of women living in regions where ivermectin mass drug administration campaigns run…
PREPRINTFitness
~6,561 Steps/Day Linked to Optimal Quality of Life in Large Accelerometer Study
In a pooled analysis of 9,371 adults (median age 62, 47% female), thigh-worn accelerometry revealed curvilinear…
PREPRINTLongevity
21,522-Patient Algerian Cohort Reveals Opposing Sex-Specific CVD Risk Profiles
Among 21,522 Algerian adults in a nationwide cardiometabolic screening cohort, sex-stratified analysis revealed…
PREPRINTLongevity
78,113-Person 4D Cardiac AI Uncovers 26 Hidden Genetic Loci in Non-Myocyte Cells
Applying unsupervised deep learning to four-dimensional cardiac MRI from 78,113 UK Biobank adults, researchers…
PREPRINTLongevity
NOAC Use Associated With Lower Cognitive Impairment Risk in AF Patients, With Sex Differences in Dementia Subtype Associations
Among 66,885 Albertans aged 40+ diagnosed with incident non-valvular atrial fibrillation between 2012–2024, females…
PREPRINTLongevity
Functional Daily-Life Assessment Boosts Alzheimer's Risk Algorithm Accuracy by Key AUC Margin
In the Bio-Hermes-001 cohort — 945 participants including a notably diverse sample (roughly one-third from populations…
Studies
Fatty Liver Disease Linked to Nearly Triple Eosinophilic Esophagitis Risk
Metabolic liver disease has long been understood as a systemic condition, but its reach into the esophagus has been…
Studies
HbA1c Outperforms Liver Fibrosis Scores in Predicting Cardiovascular Risk for T2D-MASLD Patients
When two common chronic conditions converge — type 2 diabetes and fatty liver disease — clinicians face a puzzle…
Studies
sRAGE and Lung Function Predict Asthma Flares Differently by Allergy Type
Pediatric asthma management has long treated exacerbation risk as a relatively uniform problem, but stratifying…
Studies
CKD Patients Median Three Comorbidities; Greater Number Associated with Higher Mortality Risk
For the millions living with chronic kidney disease, the disease itself is rarely the only adversary. Understanding…
Studies
LARS Enzyme Drives Liver Cancer Growth by Suppressing Cellular Senescence
Understanding why some liver cancers grow aggressively while resisting natural cell-death signals has been a…
Studies
Multimodal Bladder Pain Therapy Achieves 58% Success Where Single Treatments Fail
Interstitial cystitis and bladder pain syndrome rank among the most treatment-resistant chronic conditions urologists…
Longevity
Mitochondrial-Nuclear Signaling Breakdown May Precede Classic Alzheimer's Pathology
The dominant narrative around Alzheimer's disease has centered on amyloid plaques and tau tangles for decades, but…
Studies
Ketamine and Psychedelics Share Neuroimmune Pathway Tied to Rapid Antidepressant Effect
The question of why two pharmacologically distinct drug classes — NMDA receptor antagonists like ketamine and…
Longevity
Alzheimer's Brains Harbor Novel Mitochondrial Plaque Structures Driven by Lysosomal Failure
For decades, amyloid plaques have dominated the narrative of Alzheimer's disease pathology — but mounting evidence…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.