PREPRINTLongevity
LBBB Triples Cardiovascular Risk; RBBB Uniquely Predicts Stroke in 14,000-Person Cohort
In 14,212 adults aged 45–74 from the Hamburg City Health Study, complete left bundle branch block (cLBBB) carried a…
PREPRINTLongevity
5 Extreme Epigenetic Scores Double Death Risk in 2,594 Heart Failure Patients
In a prospective multinational cohort of 2,594 heart failure patients across 40 countries, fifteen DNA methylation…
PREPRINTStudies
CABG Cuts Death Risk vs. PCI in Diabetic, CKD Heart Patients: Meta-Analysis of 10,594
Across 19 studies drawn from nine randomized controlled trials enrolling 10,594 participants, coronary artery bypass…
PREPRINTFitness
12-Week Group Walking Program Cuts Fear-of-Falling Barrier in 73-Year-Olds
A 12-week community-based walking intervention called MABIDA enrolled 52 older adults (mean age 73.3±5.7 years) with…
PREPRINTWellbeing
66% of Dementia Caregivers Use Online Peer Support—But Half Only Lurk
Among 1,113 unpaid informal caregivers of people living with Alzheimer's disease or related dementias (ADRD), 66.5%…
Studies
India's TB Elimination Gap: MDR Strains, COVID Disruption, and Diagnostic Failures
Carrying more than a quarter of the world's tuberculosis burden, India's trajectory toward elimination reveals a…
Studies
Spinal Cord Stimulation Cuts Diabetic Neuropathy Pain With Strong Meta-Analysis Signal
For the estimated 26 million adults worldwide living with painful diabetic neuropathy — a condition notoriously…
Supplements
CT130 Biweekly GLP-1R Agonist Beats Semaglutide Weekly Via Receptor Recycling Mechanism
CT130, a semaglutide-derived GLP-1R agonist engineered for biweekly dosing, achieved superior metabolic outcomes…
Studies
Tirzepatide After Gastric Bypass: First RCT Targets Persistent Obesity in 28 Patients
The GRABS trial is the first randomized controlled study examining tirzepatide (a dual GIP/GLP-1 receptor agonist) as…
Studies
Tirzepatide Linked to 84% Higher Arrhythmia Odds in 6,515-Person Meta-Analysis
Across 10 randomized controlled trials enrolling 6,515 overweight or obese adults, tirzepatide — the dual GIP/GLP-1…
Longevity
STAMP-F Framework Proposes Frailty Integration Into 2026 ESC Cardiorenal Guidelines
The 2026 European Society of Cardiology guidelines for cardiovascular disease and chronic kidney disease offer a…
Studies
Plant Compound Blocks TRIM21-PRDX1 Axis to Reduce Ischemic Brain Damage
Stroke remains one of the leading causes of death and disability worldwide, yet the molecular cascade triggering…
Studies
Hex-MASP Platform Maps Whole-Tissue Protein Distribution With Spatial Precision
Understanding how proteins are spatially organized within tissues is fundamental to decoding disease mechanisms, drug…
Studies
Lenacapavir Disrupts HIV Assembly by Triggering Abnormal Giant Virion Formation
Understanding precisely how HIV drugs block viral replication at the molecular level is not an academic exercise — it…
Studies
Nickel Delivery Mechanism to H. pylori Urease Reveals Potential Drug Target
Understanding how a stomach-colonizing bacterium assembles one of its most essential survival tools could reshape how…
Studies
Atomic Structure Reveals How Clotting Factors Selectively Recognize Injury-Exposed Membranes
Understanding precisely how the blood clotting cascade homes in on sites of vascular damage — and not on healthy…
Studies
KRAS Oncogene's Cancer-Causing Power Depends Heavily on Tissue of Origin
Understanding why the same genetic mutation causes cancer in some tissues but not others is one of oncology's most…
Studies
CTGF-Expressing Fibroblasts Drive Pancreatic Cancer Progression via Stroma Signaling
Pancreatic ductal adenocarcinoma remains one of oncology's most intractable problems, with five-year survival rates…
Nutrition
Salmonella Toxin Hijacks Intestinal Fat Absorption Machinery During Infection
Understanding how gut infections alter nutrient absorption could reframe how clinicians think about both the acute…
Studies
Brain-Produced Ketones Enable Neural Activity Independent of Blood Glucose
For over a century, neuroscience has treated the brain as an obligate glucose consumer — a fragile organ that shuts…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.