PREPRINTFitness
Five Proteins Predict Which Heart Failure Patients Gain Most from Exercise Rehab
In 243 older adults (≥60 years) hospitalized for heart failure and enrolled in the REHAB-HF trial, pre-intervention…
Wellbeing
Each Year After Quitting Smoking Cuts Fracture Risk ~1% in Older Women
In a prospective cohort of 3,024 Swedish women aged 75–80, current smokers faced a 35% higher risk of any fracture (HR…
Nutrition
Mediterranean Diet Cuts Ferritin 22 ng/mL in Metabolic Syndrome Over 32 Weeks
A 32-week, 30%-energy-deficit Mediterranean-style intervention in 190 overweight adults revealed that ferritin…
Longevity
Statins Cut All-Cause Mortality 20% in Older Cancer Survivors With Heart Disease
Among 2,714 U.S. cancer survivors aged 65+ drawn from ten NHANES cycles (1999–2018), statin use was independently…
Nutrition
Soy Diet Cuts Hot Flash Frequency But Evidence Remains Very Low Certainty
Across 15 randomized controlled trials enrolling 1,952 women aged 40–65, soy-based dietary interventions produced a…
Fitness
7,500–10,000 Steps at ~100 Steps/Min Cuts Death Risk 43%
In a prospective analysis of 64,743 UK Biobank participants (mean age 61.5 years, 1,697 deaths), the sweet spot for…
Longevity
Deleting Lsp2 Gene Extends Drosophila Lifespan Via mTORC1-TOP mRNA Axis
In Drosophila, genetic ablation of Lsp2 — a protein previously classified only as a larval storage protein but now…
Nutrition
8-Month Nutrition Education Cuts Cholesterol, BMI in Family Farmers
An 8-month nutrition education intervention across 7 structured sessions improved diet quality scores in 81 Brazilian…
Nutrition
Low Fish, Legumes, and Fruit Intake Linked to 4-6x Higher MASLD Odds
In a case-control study of 111 adults attending a diet clinic in Turkey, consuming less than one fish serving per week…
Studies
GLP-1/SGLT-2 Drugs Cut Kidney Failure Risk 40% — But Only With Albuminuria
In a target trial emulation drawing on 75,455 adults with type 2 diabetes across 12 U.S. health systems, GLP-1…
Studies
Fracture-Prevention Drugs in Men: Cochrane Review Finds Thin Evidence
A Cochrane systematic review pooled 17 randomised controlled trials enrolling 4,132 men aged 50–73 to evaluate…
Wellbeing
Chronic Stress + Poor Habits Triple Mortality Risk in Fatty Liver Disease
Among 9,761 NHANES participants followed for a median of 7.42 years, 32.4% carried a diagnosis of metabolic…
Nutrition
Diet Drives 40% of Colorectal Cancer Deaths; Burden Rising to 2030
Analysis of Global Burden of Disease 2023 data across G20 nations spanning 1990–2023 finds that dietary risks account…
Fitness
26 Trials: Exercise Boosts Upper-Limb Bone Density in Women by Large Margin
Across 26 controlled trials involving 1,880 women, exercise produced a large pooled effect on upper-limb bone outcomes…
Nutrition
70% Plant Protein Diet Cuts TMAO by 4.6 μg/mL in Advanced CKD Patients
In a 4-week randomized controlled trial of 36 Japanese patients with severely impaired kidney function (median eGFR 13…
Supplements
Probiotic Converts Citrus Compound to Activate Longevity Gene, Reversing Age-Related Metabolic Decline
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Fitness
Each 1 mL/kg/min Higher VO2peak Cuts Cardiac Event Risk 7% in Men
In 1,651 Norwegian coronary artery disease patients (21% women, mean age 61) followed across 7,880 person-years of…
Longevity
Combined BP, Grip Strength & Waist Ratio Doubles Stroke Risk in 40,000+
Across three major longitudinal cohorts totalling 40,520 middle-aged and older adults (CHARLS, ELSA, HRS), a composite…
Longevity
High Uric Acid Triples Mortality Risk in Older Women: Cohort Data
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
Fitness
Cardiorespiratory Exercise After Stroke: 53-Trial Cochrane Meta-Analysis
A Cochrane systematic review and meta-analysis of 53 randomised controlled trials (2,672 participants, mean age 61.9…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.