PREPRINTWellbeing
Second Arterial Grafts Show No Survival Difference in 14,196 Bypass Patients
Analysis of 14,196 Dutch cardiac bypass patients reveals that choosing between radial artery or right internal…
PREPRINTStudies
PCSK9 Inhibitors Show 26% Lower Depression Risk Than Statins
Analysis of 35,610 matched patients with hyperlipidemia revealed PCSK9 inhibitors reduced depression risk by 26%…
PREPRINTStudies
Russian Dementia Rates Show 160x Variation Across Screening Methods
A systematic review of 20 population studies found dramatic variation in dementia prevalence estimates across Russia…
PREPRINTWellbeing
Self-Reported Sleep Problems Associated with 42-50% Higher Fall Risk and Impaired Daily-Life Gait Quality in Older Adults
Among 758 community-dwelling adults over 65, those reporting sleep problems showed significantly impaired daily-life…
Studies
Lower Respiratory Infections Still Lead Infectious Disease Deaths Globally Despite Three-Decade Prevention Efforts
The persistence of lower respiratory infections as humanity's top infectious killer reveals critical gaps in global…
Longevity
GLP-1 Drugs Show Cardiovascular Protection Beyond Weight Loss Effects
Large-scale randomized controlled trials reveal that GLP-1 receptor agonists deliver cardiovascular risk reduction and…
Supplements
Tirzepatide Outperforms Semaglutide for Weight Loss in Real-World Study
A 36-week Turkish clinic study comparing three GLP-1 receptor agonists in 200+ non-diabetic adults with overweight or…
Longevity
GLP-1 Receptor Agonists Associated with Weight Loss and Reduced Inflammation Markers in Small Psoriatic Arthritis Cohort
GLP-1 receptor agonists produced a 6.4 kg average weight loss in 48 psoriatic arthritis patients, with 60% achieving…
Longevity
AMG 133 Dual-Target Antibody Shows Superior Weight Loss in Preclinical Obesity Studies
AMG 133 represents a breakthrough dual-mechanism approach combining GIP receptor antagonism with GLP-1 receptor…
Longevity
Exercise Hormone Irisin Drops 50% in Aging Brain Protection System
FNDC5/irisin levels in extracellular vesicles dropped significantly in older adults (65-79 years) compared to young…
Studies
Salton Sea Dust Exposure Linked to Reduced Lung Growth in Children
California's massive environmental experiment is playing out in real time as the Salton Sea continues shrinking…
Studies
Nucleotide Analogue Bemnifosbuvir Shows Promise Against Chronic Hepatitis E Infections
Chronic hepatitis E virus infection represents a particularly dangerous threat for immunocompromised patients, who can…
Studies
MFAP2 Protein Creates Multi-Step Pathway Blocking Immune Attack on Tumors
The discovery of how tumors manipulate their surrounding tissue to evade immune destruction reveals a sophisticated…
Studies
Mouse Model Successfully Replicates Hepatitis-to-Cancer Progression Using Rat Virus
Liver cancer research has long struggled with a fundamental problem: the lack of small animal models that accurately…
Longevity
American College of Clinical Pharmacology Urges Weighing Risks and Benefits of Off-Label Sirolimus for Anti-Aging
The growing pursuit of pharmaceutical anti-aging interventions has reached a critical juncture where medical societies…
Studies
Checkpoint Inhibitors Show Promise Against Aggressive Neuroendocrine Tumors
Aggressive neuroendocrine tumors in the digestive system represent one of oncology's most challenging therapeutic…
Studies
Hospitalization During Birth Offers Critical Window for Opioid Treatment
The vulnerable period around childbirth presents a unique therapeutic opportunity that healthcare systems are still…
Longevity
Mitochondrial DNA Emerges as Master Switch for Cellular Inflammation
The discovery that cellular powerhouses moonlight as immune sentries could revolutionize how we understand chronic…
Wellbeing
Microplastics Act as Environmental Modifiers of Lung Disease Through Five Distinct Cellular Pathways
The invisible pollution crisis in our homes and workplaces may be fundamentally altering how respiratory diseases…
Studies
Blood Test Detects Two Major Gastrointestinal Cancers With 88% Accuracy
Early detection of colorectal and gastric cancers could dramatically improve survival rates for the 1.6 million people…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.