Longevity
GH Receptor Antagonism Extends Mouse Lifespan by Up to 265 Days
Transgenic mice expressing a growth hormone receptor antagonist (GHA) — engineered via a glycine-to-lysine mutation at…
Studies
Blocking Kir7.1 Channel Reverses Clozapine Weight Gain Without Losing Antipsychotic Effect
Weight gain from antipsychotic medications is one of psychiatry's most stubborn clinical problems — it drives…
Wellbeing
Severe Breathlessness Doubles Loneliness Risk in Adults Over 50
Loneliness is increasingly recognized as a clinical outcome in its own right, yet its intersection with respiratory…
Fitness
Six Months of Exercise Slows Hippocampal Atrophy and Reshapes Sleep-Brain Connectivity in Alzheimer's
For the millions of adults navigating early Alzheimer's disease or mild cognitive impairment, the question of whether…
Studies
Blood-Level Statin Monitoring Reveals Near-Perfect AMI Trial Adherence With Clear Plaque Benefits
For decades, cardiovascular prevention research has wrestled with a stubborn confound: patients in trials who say…
Fitness
Lifelong Athletic Training Slows But Cannot Stop Age-Related Physical Decline
For adults seeking evidence-based strategies to preserve physical capacity into old age, the master athlete model…
Studies
Metastatic Prostate Cancer Survival Gains Outpace Localized Disease Over 14 Years
The biggest survival gains in prostate cancer over the past decade have not come from refining care for early-stage…
Supplements
Oral Semaglutide's 0.4–1% Bioavailability: SNAC Workaround and What Comes Next
Oral semaglutide, despite its commercial availability, achieves only 0.4–1% absolute bioavailability under strict…
Supplements
Tirzepatide Breaks Refractory Diabetes Barrier Where GLP-1 Alone Failed in PWS
A woman with genetically confirmed Prader-Willi syndrome (15q11.2-q13.1 heterozygous deletion, verified by DNA…
Longevity
GLP-1R Agonist Exendin-4 Halts Implant Bone Loss via Dual Anti-Inflammatory/Anabolic Mechanism
A GLP-1 receptor agonist best known for diabetes and weight management demonstrates a compelling orthopedic…
Longevity
GLP-1 Agonists Cut MACE Risk 37% vs. Spironolactone in Resistant Hypertension
Among 4,153 propensity-matched adults with resistant hypertension and overweight/obesity, initiating GLP-1 receptor…
Supplements
Whey Protein Beats HMB for Grip Strength in Sarcopenic Elders: Meta-Analysis
Across 7 high-quality RCTs enrolling 472 older adults with sarcopenia, combining strength training with whey protein…
Longevity
MERCS Dysfunction Proposed as Upstream Driver of Microglial Senescence in Alzheimer's
Mitochondria-endoplasmic reticulum contact sites (MERCS) coordinate calcium shuttling, mitochondrial fission-fusion…
Wellbeing
Rural Brain-Health Screening Program Uncovers High Dementia Risk Factor Burden
Cognitive decline does not announce itself equally across geography. Rural adults — who represent nearly 20% of the…
Studies
Neonatal Fibroblasts Outperform Adult Cells in Beta-Cell Reprogramming Efficiency
For the millions living with insulin-dependent diabetes, the prospect of generating functional beta cells outside the…
Studies
Transvaginal Ultrasound Quantifies Retrograde Menstruation Via Pelvic Fluid Tracking
Retrograde menstruation — the backflow of menstrual blood through the fallopian tubes into the pelvic cavity — has…
PREPRINTStudies
96% Drop in China's Child Respiratory Deaths Unlinked to Warming After Detrending
China's childhood lower respiratory infection mortality collapsed from 330,194 deaths in 1990 to 12,098 in 2021—a…
PREPRINTStudies
Summer Alcohol Injuries Peak Predictably in Adults 25–64, But Not Elderly Women
Analysis of 45,876 alcohol-associated emergency department visits (weighted national estimate: ~2.09 million) drawn…
PREPRINTLongevity
Guatemala's First Population-Based Aging Study Targets 40% Indigenous Maya Population
A pilot cross-sectional household survey of up to 600 adults aged 40 and older in Tecpan, Guatemala has established…
PREPRINTStudies
59% Publication Rate at ADA Sessions Reveals Persistent Null-Result Suppression
Among 541 abstracts presented at the 2018 American Diabetes Association Scientific Sessions, only 59.3% were…
Browse Topics
Longevity & Anti-Aging Research Nutrition & Diet Science Exercise & Fitness Science Wellbeing & Integrative Health Medical Studies & Clinical Trials Supplements & Nutraceuticals✉️ Stay Updated
Get daily health research summaries delivered to your inbox.
Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.