Longevity
BRCA1 Mutation Carriers Face Hidden Fatty Liver Risk Regardless of Sex
Heterozygous loss of Brca1 — mirroring germline BRCA1 mutations in humans — produces a striking paradox: female mice…
Studies
GLP-1 Agonists Boost FEV1 by 6 Points in Cystic Fibrosis Diabetes
Among 23 adults with cystic fibrosis-related diabetes (CFRD) initiating GLP-1 receptor agonist therapy, median FEV1…
Nutrition
TMAO, PAGln & 5 Gut Metabolites Link Diet Patterns to CVD Risk
Seven microbiota-derived metabolites — TMAO, LPS, SCFAs, bile acids, phenylacetylglutamine (PAGln), indolepropionic…
Longevity
Dasatinib/Quercetin Reverses Doxorubicin Bone Loss via Senescence Clearance in Mice
Doxorubicin chemotherapy in young (3-month) and aged (20-month) male and female mice triggered accelerated skeletal…
Supplements
Glutathione Supplementation Shows Metabolic Promise in Type 2 Diabetes, Safety Confirmed
For the roughly 500 million adults living with type 2 diabetes globally, oxidative stress is not a side effect — it is…
Studies
20mg THC Edibles Impair Simulated Driving Up to Five Hours Post-Ingestion
As cannabis edibles become increasingly mainstream, a critical blind spot has persisted in road safety science: how…
Studies
Finerenone Cuts Cardiovascular Risk Regardless of Diabetes Treatment Goal Attainment
For the millions of adults living with both type 2 diabetes and chronic kidney disease, achieving every recommended…
Studies
General-Purpose ChatGPT-5 Outperforms Regulated AI in Breast Cancer Treatment Planning
The assumption that regulatory clearance guarantees superior clinical performance is one of medicine's quietly held…
Longevity
U.S. Cancer and Heart Disease Deaths Fell 20%-Plus; Brain Diseases Rose
Two decades of American health data reveal a striking paradox: medicine has become remarkably effective at extending…
Longevity
EP2 Receptor Blockade Reverses Multi-Organ Aging by Restoring Senescent Neutrophil Clearance
A single molecular target governing the pace of multi-organ aging would be transformative for longevity medicine. New…
Longevity
Blocking One Immune Receptor Reverses Multi-Organ Aging in Mice
The assumption that aging's toll on organs is largely irreversible may need serious revision. A newly identified…
Studies
Vasohibin-1 Protein Linked to Arrhythmia Risk in Pressure-Overloaded Heart Tissue
For the millions of adults living with hypertension or aortic stenosis, the transition from compensated cardiac…
Studies
Myelin Sheaths Function as Oxygen Reservoirs Fueling Axonal Energy Metabolism
A fundamental assumption in neuroscience has long held that myelin's primary role is electrical insulation — speeding…
Studies
Inner Ear Dysfunction Confounds Depression Behavior Tests in Mouse Models
How confidently can researchers claim a mouse is 'depressed'? That question sits at the heart of a methodological…
Studies
Immune Protein RNF213 Destroys Chlamydia Vacuoles via Non-Autophagy Cell Death
Understanding how human cells eliminate intracellular bacterial pathogens has profound implications for treating…
Wellbeing
Early Adversity Leaves Sex-Specific Neurobiological Marks Across Multiple Brain Systems
The long shadow of childhood adversity on adult mental health is well documented epidemiologically, but the precise…
Studies
Cerebellum's Sparse Circuits Sustain Decision-Making Via Cortical Coupling
The assumption that complex decision-making is the exclusive province of the cerebral cortex is being systematically…
Studies
Secreted Ligand Signaling Drives Cancer Cell Competition in Liver Metastasis
Understanding why colorectal cancer so frequently spreads to the liver—and why some metastatic cells outcompete…
Studies
Human Genome Harbors Genetic Variants That Locally Modulate Mutation Rates
The assumption that every person accumulates DNA errors at roughly the same pace has quietly underpinned cancer risk…
Studies
RNA-Binding Protein PTBP1 Locks Fibroblasts in Scarring State via AKT3 Switch
Fibrosis — the runaway scarring that stiffens and destroys organs — kills more people globally than many cancers, yet…
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Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.