Longevity
PROMETHEUS Trial Tests Gerotype-Personalized Supplements and Exercise Over Eight Weeks
Precision medicine for aging is moving beyond one-size-fits-all recommendations, and a new feasibility trial is…
Studies
CRBN Molecular Glue Selectively Degrades KAT2A Without Canonical Degron Recognition
A fundamental assumption in targeted protein degradation has been that the target protein must display a recognizable…
Longevity
Tiny Mitochondrial Peptide STMP1 Links Cristae Collapse to Cardiac Aging
For decades, heart failure research has focused on contractile proteins, ion channels, and neurohormonal pathways…
Studies
Grape Nanoparticles Deliver Resveratrol to Block NPC via FASN/MAPK Suppression
Grape peel-derived exosome-like nanoparticles (GELNs) — isolated via ultracentrifugation — effectively shuttle…
Nutrition
Chaga-Derived DBL Protects Poultry Gut from LPS Injury via Mitophagy Restoration and Apoptosis Suppression
A polyphenolic compound called 3,4-Dihydroxybenzalacetone (DBL), extracted from the medicinal fungus Inonotus obliquus…
Supplements
Grape Polyphenol Trio Tested in RCT for Stress Resilience at Three Doses
A parallel-arm, double-blind, placebo-controlled trial at Mount Sinai's Depression and Anxiety Discovery Center is…
Supplements
Resveratrol Blocks Pyrethroid Pesticide Cardiotoxicity via ROS Suppression in Zebrafish
At environmentally relevant concentrations of 3.5–7 μg/L, the type II pyrethroid pesticide fenvalerate (FEN) caused…
Longevity
ABL1 Kinase Drives Post-Op Cognitive Decline via mTOR/ULK1 Autophagy in Aged Mice
ABL1 tyrosine kinase directly binds mTOR and, in aged mice modeling postoperative cognitive dysfunction (POCD), drives…
Longevity
FGF21 Reverses Stem Cell Aging via TFE3-Autophagy-SIRT1-mTOR Cascade
FGF21 (fibroblast growth factor 21) reverses senescence in aged human adipose-derived mesenchymal stem cells (ASCs) by…
Longevity
Single-Cell Analysis Suggests MMC May Induce SASP-Like State in Some Surviving Fibroblasts After Glaucoma Surgery
Trabeculectomy's gold-standard adjunct mitomycin C (MMC) kills most fibroblasts to prevent scarring—but single-cell…
Supplements
100mg Daily Fisetin Targets suPAR Inflammation Marker in First RCT Protocol
A Danish triple-blind, randomised, placebo-controlled trial is testing whether 100 mg of oral fisetin daily for 7…
Longevity
Delayed Senescent Cell Clearance at 4 Months Reverses Radiation-Induced Aging in Mice
Using the INK-ATTAC transgenic mouse model, selective elimination of p16Ink4a-positive senescent cells at 4 months…
Studies
TRAVERSE Trial Clarifies TRT Cardiac Safety While Flagging Secondary Risk Signals
For over a decade, clinicians prescribing testosterone replacement therapy to older hypogonadal men have operated in…
Studies
AI Transformer Model Outperforms Cox Methods for Chinese Cardiovascular Risk
Cardiovascular risk calculators built on decades-old statistical frameworks may be systematically underserving more…
Studies
GI Cancers Before 50 Rising Globally: Microbiome and Metabolism Implicated
A troubling epidemiological inversion is underway in gastrointestinal oncology: cancers of the colon, rectum, stomach…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Threatens 2035 Targets
Tuberculosis remains one of the most consequential infectious disease challenges of the modern era, and understanding…
Studies
65% Exacerbation-Free at One Year After Stopping Severe Asthma Biologics
For the roughly one-third of severe asthma patients on biologics who eventually stop treatment — whether by choice…
Studies
VR and AR in Shoulder Surgery: Promising Tools, Still Limited Evidence
As digital tools reshape orthopedic surgery, understanding which technologies are ready for the operating room versus…
Studies
BTK Inhibitors Cross Blood-Brain Barrier, Targeting Progressive MS Pathology
For the roughly 15% of multiple sclerosis patients who never experience relapses and the larger proportion whose…
Studies
First Phase 3 Trial Shows Oral AD109 Reduces Sleep Apnea Severity by 44%
For the roughly 30–50% of sleep apnea patients who cannot or will not tolerate CPAP machines, the absence of a proven…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.