Studies
NEJM Trial Challenges Anticoagulation Decisions for Intermediate AF Stroke Risk
One of the most contested gray zones in cardiology — whether patients with atrial fibrillation at intermediate stroke…
Studies
Personalized Antibiotic Duration Matches Standard Care for Endocarditis Outcomes
Infective endocarditis carries one of the highest mortality rates among bacterial infections, and the current standard…
Studies
Aficamten Improves Exercise Capacity in Nonobstructive HCM Phase III Trial
Hypertrophic cardiomyopathy without outflow obstruction has long been a therapeutic dead end — a condition where the…
Studies
London's Ultra-Low-Emission Zone Linked to Accelerated Lung Function Growth in Children
Lung function established during childhood is one of the strongest long-term predictors of adult respiratory health…
Studies
Five-Year Brain Organoids Replicate Postnatal Epigenetic Aging With Fidelity
The fidelity with which lab-grown tissue can replicate actual human biology has long been the central limitation of…
Studies
Potent P2Y12 Plus DOAC Raises Bleeding Risk Without Ischemic Benefit in AF-ACS
Managing patients who have both atrial fibrillation and an acute coronary syndrome is one of cardiology's sharpest…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have…
Longevity
Mitochondrial DNA Leakage in Aging Eggs Ignites Ovarian Inflammation via Gap Junctions
Ovarian aging is one of the most consequential biological clocks in human health, setting the pace for fertility…
Studies
New Consortium Targets Sex-Based Biological Gaps in Alzheimer's Research
Alzheimer's disease does not affect men and women equally — women account for nearly two-thirds of all cases — yet…
Studies
Multi-Biomarker Wearables Could Reframe Cardiometabolic Disease Monitoring Beyond Glucose
Continuous glucose monitoring transformed diabetes management by turning a snapshot test into a living physiological…
Longevity
Silent Coronary Calcium in Young Adults Raises CHD Death Risk Fivefold
Coronary artery disease is typically framed as a condition that declares itself in middle age or later — but…
Studies
Enteric Disease Deaths Fell 60% in Children Since 1990, But Progress Stalls
Over a million deaths annually from gut infections — with children under five bearing a disproportionate share…
PREPRINTLongevity
Four AML Risk Genes Emerge from 170,000-Person Whole-Genome Biobank Scan
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls…
PREPRINTLongevity
AD Genetic Risk Maps to Liver, Gut, Heart—Not Just Brain Microglia
A large-scale genomic analysis partitioning Alzheimer's disease (AD) polygenic risk across 166 tissue annotations and…
PREPRINTLongevity
GLP-1 Drugs Linked to 0.21-Month Alzheimer's Delay vs. Sulfonylureas in 6,328 Diabetics
Among 6,328 adults aged 55+ with type 2 diabetes and no prior dementia, initiating GLP-1 receptor agonists was…
Studies
Phase 3 Trial Tests RNA-Silencing Drug Against Fatal Heart Amyloid Disease
Transthyretin amyloid cardiomyopathy remains one of cardiology's most underdiagnosed and lethal conditions — a disease…
Longevity
Sattar Perspective: Incretin-Driven Weight Loss (14-20%) and Causal Adiposity Effects Across Multiple Disease Domains
Using a triangulation framework—combining Mendelian randomisation, observational cohorts, and randomised trials—Sattar…
Longevity
Senescent Vascular Cells and SASP Linked to Intracranial Aneurysm Wall Weakening
Intracranial aneurysms may represent a localized manifestation of premature vascular aging, with senescent endothelial…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical…
Studies
Thioredoxin-Deficient Rats Develop Progressive CKD via Mitochondrial Redox Failure
Chronic kidney disease silently erodes kidney function in roughly 10% of the global population, yet the causal chain…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.