HIV Protein Hijacks Cell's SUMOylation System to Control Viral RNA Processing

A breakthrough in understanding HIV's molecular manipulation reveals how the virus commandeers a fundamental cellular p…

Brain Fluid Dynamics Show Bidirectional Coupling with Neural and Vascular Oscillations During Human Sleep

Sleep's restorative power may stem from a precisely orchestrated dance between brain waves, blood flow, and cerebrospin…

Brain Maturation Patterns Differ by Sex in Youth ADHD Studies

The assumption that delayed brain development universally characterizes attention disorders may be fundamentally flawed…

Scientists Create Functional Map of Human Intrinsically Disordered Proteins, Covering at Least One-Third of the Proteome

The discovery that more than one-third of human proteins exist in a constantly shifting, structure-free state challenge…

Lipid Nanoparticles Successfully Target Heart Cells for Gene Therapy Delivery

Heart disease remains the leading killer globally, yet genetic medicines that could potentially reverse cardiac damage…

mRNA Platform Protects Against Multiple Deadly Ebola Virus Species

The next pandemic could emerge from any of several deadly Ebola virus species, yet current vaccines protect against onl…

Optical Tool Enables Precise Brain Capillary Damage Study for Aging Research

Understanding how individual blood vessel failures accumulate into cognitive decline has been nearly impossible to stud…

Brain's Reward Benchmark System Associated with Depression Severity

The way your brain sets expectations for rewards may fundamentally determine your vulnerability to depression. This dis…

Mitochondrial Protein Interactions Control DNA Repair Helicase Function

Mitochondrial DNA maintenance becomes increasingly critical as we age, with defective repair mechanisms linked to cellu…

RNA Gene Variants Shape Temperature Adaptation Circuits in Worms

Temperature adaptation represents one of life's fundamental challenges, determining where species can survive and thriv…

AI Models Predict Extensive Protein-Carbohydrate Interactions Across Proteomes

The intricate dance between proteins and carbohydrates in human cells has remained largely hidden until now, limiting o…

Game Theory Model Reveals How Biological Cooperation Overcomes Evolutionary Selfishness

Understanding how cooperation emerges in biological systems has profound implications for human health, from cellular t…

Lab-Grown Human Tissues Show Extraordinary Shape-Shifting Without Breaking

The human body's ability to stretch, bend, and reshape during development while maintaining structural integrity has lo…

Light-Activated Tissue Mapping Preserves Cellular Architecture During Molecular Analysis

Tissue analysis just gained a powerful new dimension that could transform how researchers study disease progression and…

Morphogen Gradient Scaling Reveals Key Mechanisms Behind Proportional Development

Proportional development—how organisms maintain proper body patterns regardless of final size—represents one of biology…

SKIP

Inhaled Treprostinil Shows Modest Benefits in Pulmonary Fibrosis Trial

Progressive lung scarring affects over 200,000 Americans with idiopathic pulmonary fibrosis, a devastating condition wh…

Azithromycin Fails to Reduce Preschooler Wheezing Episodes in Emergency Settings

Emergency department visits for childhood wheezing represent a critical intervention point where effective treatments c…

Moderate Coffee Intake Shows Neutral-to-Favorable Cardiovascular Outcomes Despite Acute Effects

The cardiovascular safety of caffeine consumption remains one of the most clinically relevant questions for health-cons…

Single Moderate Exercise Session Robustly Increases Breast Milk Vesicle Concentration, With Effects Persisting Across Collections

A single moderate-intensity exercise session dramatically increased the concentration of small extracellular vesicles (…