Longevity
Knee OA Reframed as Joint Aging: GAE and Senescence Targets Evaluated
A structured narrative review spanning PubMed/MEDLINE and Embase (2010–2026) positions knee osteoarthritis not as a…
Wellbeing
Early-Life Inflammation Primes Brain Immune Cells for Adult Depression via BAG3
The idea that adult depression can be partially shaped by events occurring in the first days of life challenges a…
Studies
Mathematical Model Captures MS Relapse Cycles via Hopf Bifurcation Dynamics
Multiple sclerosis affects nearly 2.9 million people worldwide, yet its relapsing-remitting cycles remain poorly…
Fitness
90–120 Minutes Weekly Resistance Training Linked to 13–27% Lower Mortality Risk
For decades, cardiovascular exercise dominated longevity conversations, but mounting evidence is repositioning…
Studies
Six Drug Classes Show Promise Against Untreatable Sensorineural Hearing Loss
Sensorineural hearing loss affects hundreds of millions of adults globally, yet no approved pharmacological treatment…
Wellbeing
Sleep Spindle Timing and Slow-Wave Shifts Reveal First-Night Effect Mechanisms
Anyone who has ever slept poorly in an unfamiliar environment—a hotel, a sleep lab, a friend's guest room—has…
Studies
CXCR6 Blockade Disrupts Th17-Macrophage Crosstalk to Halt Sarcoidosis Fibrosis
Pulmonary sarcoidosis has long resisted disease-modifying therapy, with corticosteroids remaining the default despite…
Nutrition
Taste and Smell Genetics May Unlock Personalized Dietary Interventions
Why two people following identical diets can have vastly different outcomes has long puzzled nutrition scientists…
Studies
2024 AHA/ACC Guidelines Reshape Perioperative Cardiac Risk Stratification Protocols
For the millions of adults undergoing noncardiac surgery each year, cardiac complications represent one of the most…
Studies
Daraxonrasib Resistance Patterns in PDAC Reveal Rational Combination Therapy Targets
Pancreatic ductal adenocarcinoma remains one of oncology's most intractable challenges precisely because KRAS…
Studies
Antibody-Light Conjugate Eliminates Key Periodontal Pathogen Without Disrupting Oral Microbiome
The ability to surgically target a single bacterial species within a complex microbial community — without collateral…
Studies
Daraxonrasib Resistance Mechanisms Illuminate Combination Therapy Paths in Pancreatic Cancer
Pancreatic cancer remains one of oncology's most intractable challenges, with five-year survival rates stubbornly…
Studies
Dual-AAV Otoferlin Gene Therapy Restores Hearing in Mice, Enters Human Trials
For families affected by DFNB9-related congenital deafness — a condition that silences children from birth — gene…
Longevity
TNFR1-Driven Inflammation Disrupts Fatty Acid Metabolism in Aging Gut Stem Cells
Gut health in older adults may be more tightly tied to systemic inflammation than previously understood — and a newly…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls Before 2035 Target
Tuberculosis remains one of humanity's most consequential infectious disease failures — a curable disease that still…
Nutrition
First-1000-Days Sugar Restriction Linked to 27–46% Lower Dementia Risk Decades Later
What adults eat in the first years of life may shape their brain's vulnerability to dementia and psychiatric illness…
PREPRINTStudies
cLFLG Subtype Associated with MR Worsening After TAVR in 614-Patient Study
Among 614 low-flow aortic stenosis (LFAS) patients undergoing transcatheter aortic valve replacement (TAVR), mitral…
PREPRINTStudies
Llama 3.3 70B Achieves 100% Sensitivity Identifying PCI Procedures in Clinical Notes; Near-Perfect for Complex Cases
A large language model — Llama 3.3 70B — achieved 100% sensitivity and 93.8% specificity in identifying percutaneous…
PREPRINTLongevity
Neighborhood Gun Violence Associated with 0.5% Lower Endothelial Function in Black Teens, with Diet and Adiposity as Mediators
In a prospective cohort of 400 Black adolescents from lower-income Chicago households, exposure to neighborhood gun…
PREPRINTStudies
PCAT Fat Imaging Biomarker Decoupled from Local Coronary IL-6 and IL-1β in Stable CAD
In 31 adults with stable coronary artery disease, pericoronary adipose tissue (PCAT) attenuation measured on CT…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.