Resveratrol supplementation at 150mg daily provided specific anti-inflammatory and cartilage-protective benefits beyond a low-calorie diet alone in 97 postmenopausal women with obesity and knee osteoarthritis. While both groups experienced improvements in weight, glucose metabolism, and joint pain over 10 days, only the resveratrol group showed additional reductions in high-sensitivity C-reactive protein (hsCRP) and urinary CTX-II, a biomarker of cartilage degradation. This targeted benefit suggests resveratrol's polyphenolic compounds may directly modulate inflammatory pathways and protect cartilage matrix independent of weight loss effects. The finding aligns with resveratrol's established role as a sirtuin activator and NF-κB pathway inhibitor, mechanisms increasingly linked to both aging and joint health. However, the brief 10-day intervention period limits practical applications, as osteoarthritis and obesity management typically require sustained lifestyle changes. The study's small size and short duration also constrain broader conclusions about long-term efficacy or optimal dosing strategies. As this is a preprint awaiting peer review, these results require validation through extended trials before clinical recommendations can be made for resveratrol as an adjunct therapy in postmenopausal joint health.