Transcription Factor Drug Targeting: Why Cancer's 'Undruggable' Proteins May Yield
For decades, the proteins that control which genes get switched on or off inside cancer cells were considered essentially untouchable by conventional drugs…
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For decades, the proteins that control which genes get switched on or off inside cancer cells were considered essentially untouchable by conventional drugs…
For one of the most difficult-to-treat abdominal cancers, identifying who will relapse early after aggressive combined treatment has been an unsolved clinical…
For women carrying BRCA1 or BRCA2 mutations, the calculus of cancer prevention has long forced a brutal trade-off: remove the ovaries early and slash cancer…
Cancer treatment side effects — pain, anxiety, nausea, depression — remain undertreated in conventional oncology, partly because integrative modalities like…
For the estimated 7 million people living with inflammatory bowel disease worldwide, achieving and sustaining remission remains elusive partly because almost…
For the roughly half of advanced cancer patients who never receive outpatient palliative care, the barrier is rarely clinical — it's systemic. A large…
For decades, the long-term genomic consequences of surviving cancer treatment have been poorly understood — particularly how chemotherapy, radiation, and…
Antibiotics are the most commonly prescribed drug class globally, yet their long-term consequences beyond infection control have received comparatively little…
Chemotherapy-induced infertility and early menopause represent a largely unaddressed consequence of cancer treatment, affecting cardiovascular, cognitive, and…
For millions of women navigating menopause with histories of venous thromboembolism, certain gynecologic cancers, or coronary artery disease, standard…
Understanding why some people respond to anti-inflammatory drugs while others develop resistance or serious side effects may come down to a single molecular…
Drug-target Mendelian randomization using genetic variants in the GLP1R gene region as instruments—analyzed across 21 cancer types via public GWAS…
For men whose prostate cancer returns after surgery, finding where it has spread is the decisive factor in whether treatment can remain curative. A new…
As cannabis legalization spreads and cultural perceptions of its safety solidify, a critical assumption deserves scrutiny: that smoking cannabis is…
For decades, one of the most stubborn barriers in transplant medicine has been the immune system's refusal to tolerate foreign tissue. People with type 1…
Among 2,069 lung cancer patients with cardiac biomarker data drawn from a 2018–2024 Renji Hospital cohort, 15.8% (326 patients) developed cardiotoxicity after…
Glioblastoma's near-universal fatality stems less from initial tumor biology than from its almost inevitable resistance to standard chemotherapy. When…
Cerebral ischemia drives dynamic accumulation of G-quadruplex (G4) DNA structures within microglia — the brain's resident immune cells — and this accumulation…
The idea that short-term fasting might protect the gut from radiation damage has circulated in oncology for years, but the mechanism has remained…
Lung cancer remains stubbornly lethal partly because tumors commandeer the body's own cellular recycling machinery to sustain their growth — a biological…