Astrocytes Undergo Metabolic Reprogramming During Ketone Therapy Interventions
Astrocytes—the brain's primary support cells—undergo extensive metabolic and structural changes when exposed to ketone therapies including ketogenic diets, int…
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Astrocytes—the brain's primary support cells—undergo extensive metabolic and structural changes when exposed to ketone therapies including ketogenic diets, int…
Retatrutide demonstrates remarkable therapeutic potential by simultaneously targeting three hormone receptors—GLP-1, GIP, and glucagon—achieving weight losses…
The trajectory toward metabolic disease now begins alarmingly early, with profound implications for how parents, educators, and healthcare providers must appro…
The most metabolically resilient animals on Earth may hold keys to solving humanity's most stubborn health challenges. From bears that emerge from months-long…
The FAXAge trial will randomize 240 healthy adults over 65 into four groups—exercise alone, time-restricted feeding alone, both interventions combined, or cont…
The growing popularity of intermittent fasting approaches may come with an unexpected cost to sleep quality and duration. This comprehensive analysis challenge…
Eleutheroside B, a compound from Siberian ginseng, dramatically reduced amyloid-beta and tau protein accumulation while improving cognition and lifespan in tra…
Mental health practitioners may soon have a powerful new tool for personalizing depression treatment. The connection between blood sugar regulation and mood di…
Orforglipron demonstrates superior metabolic outcomes compared to oral semaglutide in head-to-head trials, achieving 2.2% hemoglobin A1c reduction versus 1.4%…
A comprehensive meta-analysis of 28 studies reveals that prenatal exposure to specific PFAS compounds—including PFOA, PFOS, PFNA, PFDA, and PFUnDA—significantl…
A comprehensive Bayesian network meta-analysis of 55 randomized trials involving 16,610 prediabetic adults reveals that GLP-1 receptor agonists and dual GIP/GL…
A controlled trial of 54 overweight college students found that combining 10-hour daily eating windows with resistance training yielded superior fat loss (3.2k…
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetically distinct mouse strains, with effects…
A comprehensive Cochrane systematic review evaluated randomized controlled trials comparing intermittent fasting protocols against standard dietary advice for…
Analysis of 45 randomized controlled trials reveals vitamin D supplementation produces statistically significant but modest improvements in key cardiovascular…
The DELTA study introduces a comprehensive N=1 protocol combining time-restricted eating, Mediterranean diet, exercise regimens, and supplementation with conti…
Extending overnight fasting by finishing meals at least three hours before bedtime significantly enhanced nighttime diastolic blood pressure dipping and autono…
Ultra-processed foods, high-fat diets, and red meat specifically trigger inflammatory bowel disease flares by disrupting gut barrier function, promoting dysbio…
Elevated circulating β-hydroxybutyrate (BHB) concentrations demonstrate significant association with reduced cognitive deterioration risk, providing compelling…
European adults with obesity achieved comparable weight reductions and metabolic improvements whether they confined eating to early morning (7am-3pm), midday (…