Gut Bacteria Predict 12-Week Weight Loss After 5-Day Fasting
A machine learning model successfully predicted which individuals would maintain weight loss 12 weeks after a 5-day fast, using baseline gut microbiome composi…
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A machine learning model successfully predicted which individuals would maintain weight loss 12 weeks after a 5-day fast, using baseline gut microbiome composi…
Mendelian randomization analysis using genome-wide genetic variants as instrumental variables demonstrates that pescatarian dietary patterns causally reduce fa…
Environmental toxin exposure may be silently undermining metabolic health in ways that interact dangerously with genetic predisposition and lifestyle choices.…
Each hour delay in starting daily food intake was associated with 0.88 mU/l higher fasting insulin, 16.17 mU/l higher post-meal insulin, and 0.30 units higher…
A subtle metabolic marker measured just one hour after glucose intake may identify the optimal window for diabetes prevention efforts. This finding challenges…
The conventional understanding of human motivation may need fundamental revision. Rather than chasing pleasure or subjective rewards, our brains appear primari…
The transition through menopause brings metabolic shifts that can destabilize weight regulation for decades, yet the hormonal mechanisms governing these change…
Astrocytes—the brain's primary support cells—undergo extensive metabolic and structural changes when exposed to ketone therapies including ketogenic diets, int…
Dietary restriction triggers coordinated activation across seven distinct longevity pathways: autophagy, FGF21 signaling, AMPK activation, mTORC1 suppression,…
Retatrutide demonstrates remarkable therapeutic potential by simultaneously targeting three hormone receptors—GLP-1, GIP, and glucagon—achieving weight losses…
The trajectory toward metabolic disease now begins alarmingly early, with profound implications for how parents, educators, and healthcare providers must appro…
The most metabolically resilient animals on Earth may hold keys to solving humanity's most stubborn health challenges. From bears that emerge from months-long…
The FAXAge trial will randomize 240 healthy adults over 65 into four groups—exercise alone, time-restricted feeding alone, both interventions combined, or cont…
The growing popularity of intermittent fasting approaches may come with an unexpected cost to sleep quality and duration. This comprehensive analysis challenge…
Eleutheroside B, a compound from Siberian ginseng, dramatically reduced amyloid-beta and tau protein accumulation while improving cognition and lifespan in tra…
Mental health practitioners may soon have a powerful new tool for personalizing depression treatment. The connection between blood sugar regulation and mood di…
Orforglipron demonstrates superior metabolic outcomes compared to oral semaglutide in head-to-head trials, achieving 2.2% hemoglobin A1c reduction versus 1.4%…
A comprehensive meta-analysis of 28 studies reveals that prenatal exposure to specific PFAS compounds—including PFOA, PFOS, PFNA, PFDA, and PFUnDA—significantl…
A comprehensive Bayesian network meta-analysis of 55 randomized trials involving 16,610 prediabetic adults reveals that GLP-1 receptor agonists and dual GIP/GL…
A controlled trial of 54 overweight college students found that combining 10-hour daily eating windows with resistance training yielded superior fat loss (3.2k…