Three Glutamate Residues Control BAP1 Tumor Suppressor Through Salt Bridges
Understanding how critical tumor suppressors lose function could unlock new therapeutic approaches for aggressive cancers like mesothelioma and uveal melanoma.…
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Understanding how critical tumor suppressors lose function could unlock new therapeutic approaches for aggressive cancers like mesothelioma and uveal melanoma.…
A fundamental assumption in cancer biology may need revision: that cellular defects consistently promote or inhibit tumor formation. New findings reveal that d…
Brain cancer patients may soon benefit from a more precise way to predict treatment outcomes, as imaging technology advances beyond what the human eye can dete…
Cancer researchers are increasingly targeting ferroptosis, a distinct form of programmed cell death driven by iron accumulation and lipid oxidation, as traditi…
Age alone may no longer disqualify patients from potentially life-saving lung cancer surgery, as surgical techniques and recovery protocols continue to evolve.…
Pancreatic cancer's notorious resistance to treatment may have met its match through a metabolic vulnerability that emerges when cancer cells try to adapt to t…
GLP-1 receptor agonists like semaglutide and tirzepatide achieve 15% weight loss in clinical trials, approaching the 20-30% reductions seen with bariatric surg…
The struggle to make immunotherapy work for more cancer patients may have found an unexpected ally in beer hops. While checkpoint inhibitors like anti-PD-1 the…
The second-most common breast cancer subtype may finally have a targeted treatment pathway, addressing a critical gap for patients facing particularly poor lon…
Understanding how colorectal tumors develop treatment resistance could transform outcomes for the 150,000 Americans diagnosed annually with this deadly maligna…
The discovery that specific bacterial toxins create identifiable mutational signatures in human colorectal cancer genomes represents a paradigm shift in unders…
Cancer survivors consuming the highest amounts of ultra-processed foods faced a 48% increased risk of death from any cause and 57% higher cancer-specific morta…
The protective sugar layer coating intestinal cells may be far more critical for cancer prevention than previously understood. When this molecular armor fails,…
Popular anti-aging supplements could be inadvertently helping one of medicine's most aggressive cancers resist treatment. This discovery challenges the widespr…
The discovery of treatment-resistant cancer mutations challenges oncologists' ability to predict which patients will benefit from precision medicine approaches…
The epidemiology of head and neck cancers is undergoing a fundamental shift that challenges traditional prevention strategies. While tobacco and alcohol remain…
For individuals carrying precancerous blood cell abnormalities that can evolve into multiple myeloma, dietary intervention may offer a scientifically-grounded…
Lung cancer treatment may be entering a new era as bronchoscopic ablation techniques offer hope for patients too frail for surgery or radiation. This approach…
The conventional approach to stomach health may be fundamentally incomplete. While eliminating H. pylori bacteria prevents gastric cancer, millions of patients…
The discovery that cancer cells can hijack normal lactate metabolism to create treatment-resistant states represents a fundamental shift in understanding tumor…