Longevity
Growth Factor GDF15 Emerges as Master Switch for Cancer Immune Evasion
Cancer's ability to evade immune destruction while reprogramming metabolism may hinge on a single molecular player that orchestrates both processes…
Search Results: "cancer"
Found 1715 results for "cancer"
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Studies
Single-Cell Analysis Reveals Hidden Pancreatic Cancer Driver Mutations
Pancreatic cancer's notorious resistance to treatment may stem from evolutionary complexities that traditional tumor analysis methods have been missing…
Studies
Blocking Surface Enzyme ENO1 Converts Tumor-Promoting Macrophages to Cancer Fighters
Cancer cells have long been known to manipulate their surrounding immune environment to fuel growth and metastasis, but the precise molecular switches…
Studies
Hidden RNA Molecule HELDR Drives Glioblastoma Aggression Independent of EGFR
Brain cancer treatment may need to look beyond traditional targets after researchers uncovered a previously unknown mechanism that drives glioblastoma's…
Longevity
Psychedelic Advocates Show No Lifespan Advantage Over Other Researchers
The longevity community has been buzzing about psilocybin's life-extending properties in mice, but new mortality data suggests the hype may be premature for…
Studies
Ensemble Machine Learning Models Predict Survival Outcomes After Liver Cancer Immunotherapy Using Baseline Clinical Data
Precision medicine for liver cancer treatment has reached a critical inflection point where artificial intelligence can meaningfully predict which patients…
Studies
Pembrolizumab Plus Paclitaxel Extends Survival in Platinum-Resistant Ovarian Cancer
The longstanding challenge of platinum-resistant ovarian cancer may finally have a breakthrough solution. For decades, women facing recurrent disease after…
Wellbeing
Triple Threat: Stress Hormones, Weight, and Cortisol Linked to Earlier Puberty by Seven Months in Girls
The timing of puberty in girls appears increasingly driven by a three-way interaction between metabolic stress, body weight, and hormone production that could…
Studies
Experimental Immunotherapy Compound Shows Mixed Results in Ovarian Cancer Trial
Advanced ovarian cancer patients facing treatment resistance may find renewed hope in combination immunotherapy approaches, though recent trial results…
Studies
4-1BB CAR T-Cell Constructs Show Superior Safety in Leukemia Treatment
The choice of molecular components in engineered immune cell therapies could dramatically impact both treatment success and patient safety in blood cancers…
Studies
Chemoimmunotherapy Combinations Show Encouraging Activity Against Metastatic Pancreatic Cancer
Metastatic pancreatic cancer remains one of oncology's most formidable challenges, with median survival times measured in months rather than years…
Studies
Dual Immunotherapy Plus Chemotherapy Shows Promise in Pancreatic Cancer Trial
Pancreatic cancer remains one of the most challenging malignancies to treat, with conventional chemotherapy offering limited survival benefits and…
Wellbeing
Three-Quarters of Working-Age Cancer Survivors Lose Jobs Within Five Years
Career disruption emerges as a hidden burden of cancer survivorship, with profound implications for long-term financial security and healthcare access among…
Longevity
iPSC-Derived Thymic Cells Could Regenerate Aging Immune Systems
Scientists have identified induced pluripotent stem cell-derived thymic epithelial cells as a promising approach to regenerate the thymus, the organ critical…
Wellbeing
Male-Female Obesity Creates Distinct Immune System Vulnerabilities and Disease Risks
Understanding how obesity affects immune function could reshape personalized medicine approaches, particularly as emerging evidence reveals that men and women…
Studies
Myeloid Cell Plasticity Drives Cancer Resistance Through Immunosuppressive Niche Formation
Understanding why cancer treatments fail could transform how we approach solid tumor therapy, particularly for cancers arising at barrier sites like the lung…
Studies
Liver Cancer Deaths Rising Faster in Rural America, Driven by Slower Declines in Hepatitis C-Related Cases
Geographic inequality in America's deadliest form of liver cancer reveals troubling access patterns that could affect millions living outside metropolitan…
Studies
Temozolomide Creates Two Distinct Senescent Glioblastoma Cell Types With Different Vulnerabilities
Temozolomide chemotherapy triggers glioblastoma cells into senescence through two distinct morphological pathways: early extension-rich cells (E-state) and…
Studies
Cellular Senescence Shows Dual Pro-Cancer, Anti-Cancer Roles in Pancreatic Cancer
Cellular senescence demonstrates a striking Jekyll-and-Hyde behavior in pancreatic ductal adenocarcinoma, initially suppressing KRAS-driven tumor formation…
Studies
Prostate Tissue Architecture Shapes Protective Memory T Cell Programming
The discovery that prostate tissue architecture fundamentally programs immune memory could reshape how we understand both prostate cancer prevention and…