Found 776 results for "longevity"
Age-related muscle decline may persist even when stem cells themselves are restored to youthful function, challenging assumptions about cellular rejuvenation t…
The rapamycin derivative FIM-X8 demonstrates significant lifespan extension in C. elegans while exhibiting reduced immunosuppressive activity and cytotoxicity…
The trajectory toward global population stabilization carries profound implications for aging societies and healthcare resource allocation. Current demographic…
The architecture of social relationships may hold unexpected keys to human health and longevity, as new comparative research reveals how different primate spec…
Exercise activates SIRT1 deacetylase across multiple organ systems including adipose tissue, hippocampus, heart, liver, bone, and skeletal muscle in both aged…
Chronic exposure to enrofloxacin, a veterinary antibiotic commonly found in environmental contamination, accelerates gut aging by damaging mitochondrial functi…
Natural experiment data from 60,768 UK Biobank participants revealed that sugar restriction during early life produces dose-dependent reductions in disease ris…
Metformin demonstrates a previously unrecognized mechanism called the 'intestinal glucotonic effect,' where reactive oxygen species upregulate GLUT1 transporte…
Cambridge biogerontology researchers argue that longevity science deserves moral support based on fundamental principles of autonomy and self-ownership, not ju…
Quercetin directly reverses cellular aging in tendon stem cells by blocking AKT phosphorylation, which stabilizes mitochondrial function and suppresses inflamm…
Researchers identified 5-androstene-3β,17β-diol (ADIOL), a steroid hormone discovered nearly 100 years ago, as the molecular bridge connecting fasting and calo…
Resveratrol supplementation at 2g daily for 42 days improved growth performance and feed efficiency while reducing diarrhea incidence in early-weaned calves co…
A comprehensive mechanistic framework proposes that ALS symptom heterogeneity stems from sequential failures in cellular maintenance systems rather than simple…
Esketamine, a derivative of the anesthetic ketamine, prevented postoperative cognitive dysfunction in aged mice by activating the SIRT3/AMPK/mTOR cellular path…
Transient dampening of nutrient signaling pathways during early adulthood creates lasting "physiological memory" that promotes healthspan decades later, even a…
Living at extreme elevations may come with an unexpected longevity cost, as chronic oxygen deprivation appears to fast-track immune system aging in ways that c…
The mystery of why some individuals reach 100 years while maintaining remarkable health may lie in their ability to preserve immune function that typically det…
The trajectory of breast cancer worldwide signals a looming health crisis that will reshape medical priorities over the next quarter-century. Current patterns…
The choice of vascular access for kidney dialysis patients represents a critical decision point that could extend survival by over two years. While conventiona…
Nearly one-third of adults now develop fatty liver disease, making dietary prevention strategies increasingly critical for long-term metabolic health. This mas…