SA-EVs Carry miRNA and EphA2 to Spread Skin Senescence Paracrinally
Senescent skin cells do more than secrete the well-characterized SASP cocktail of cytokines — they release a distinct class of extracellular vesicles (SA-EVs)…
Found 1260 results for "longevity"
Senescent skin cells do more than secrete the well-characterized SASP cocktail of cytokines — they release a distinct class of extracellular vesicles (SA-EVs)…
Cellular senescence markers appear in motor cortex and spinal cord tissue of TDP-43Q331K ALS mice before significant functional decline, establishing…
Tuberculosis remains one of the most consequential infectious disease challenges of our era, and a sweeping new analysis reveals precisely where the world…
Most cardiovascular risk goes undetected until it becomes clinical — and one underappreciated reason is that conventional fasting glucose tests miss the…
In SAMP8 accelerated-aging mice versus senescence-resistant SAMR1 controls, gut microbial diversity diverged independently of age, with nine bacterial genera…
Alamandine (Ala), a lesser-known renin-angiotensin system heptapeptide acting via the MrgD receptor, reverses multiple hallmarks of intestinal aging in…
The story of environmental fluorine contamination keeps expanding, and that expansion matters for anyone tracking chronic disease risk and chemical body…
When three seemingly distinct symptoms converge in a single patient — cognitive decline, loss of pleasure, and visible muscle wasting around the temples…
Protein quality control is one of biology's most elegant unsolved problems: how does a cell simultaneously permit wide variation in protein synthesis speeds…
Homocysteine elevation is one of the most consistently replicated cardiovascular and cognitive risk markers in aging adults, yet the intracellular machinery…
For the millions living with myasthenia gravis, current treatments are a blunt instrument — broad immunosuppression that suppresses the entire immune system…
For health-conscious adults watching population aging trends globally, a counterintuitive pattern emerging from China's public health data deserves attention…
Chronic inflammation in aging tissue has long been attributed to senescent cells, but the precise molecular trigger connecting damaged telomeres to the body's…
Cellular energy metabolism depends on mitochondria maintaining their integrity through a continuous quality-control process — and new molecular evidence…
The assumption that men and women simply age at different speeds is giving way to a more granular picture: certain organs and molecular systems age along…
Skin aging has long been attributed to cumulative oxidative damage, but a newly synthesized framework shifts the focus to a specific enzymatic failure point…
Muscle wasting in aging has long resisted a unified mechanistic explanation, leaving clinicians without a clear molecular target. A new preclinical finding…
Real-time, objective anxiety detection has long been a gap in mental health care, where diagnosis depends almost entirely on self-report. A system that can…
A narrative review from Semmelweis University synthesizes cross-disciplinary evidence positioning the gut microbiome as a central biological interface through…
A 24-week parallel-arm randomized controlled pilot trial — the DiAL Health study — is enrolling 90 healthy adults (BMI 22–29.9, ages 22–45) across five arms…